{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:46:53Z","timestamp":1790063213369,"version":"4.0.1"},"reference-count":15,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Purpose: Retained products of conception (RPOC) are a common complication after pregnancy. While hysteroscopic resection is the standard treatment when RPOC does not resolve spontaneously, highly vascular tissue can lead to severe bleeding during the procedure. This study assessed clinical outcomes, procedural safety, and reproductive performance in patients with highly vascular RPOC treated with uterine artery embolization (UAE) prior to hysteroscopy, compared to those treated with hysteroscopy alone. Methods: This retrospective study included 42 women diagnosed with RPOC at University Medical Centre Ljubljana, Slovenia (2010\u20132020). Patients were divided into two groups: UAE followed by hysteroscopic resection (UAE + HSC, n = 21) and hysteroscopic resection alone (HSC-only, n = 21). Data on clinical outcomes, complications, and reproductive history were analyzed using Fisher\u2019s exact and t-tests (p &lt; 0.05). Results: Groups were similar in baseline characteristics, except for greater vascularity in the UAE + HSC group (100% vs. 4.8%, p &lt; 0.05). Bleeding &gt;300 mL occurred more often in the UAE + HSC group, but all cases were managed conservatively and only one patient required transfusion. No uterine perforations occurred. Residual RPOC was found in one patient per group. Rates of endometritis, menstrual changes, and pelvic pain were comparable. Among those who attempted conception, live birth and miscarriage rates did not differ significantly. Conclusions: UAE prior to hysteroscopic surgery appears to be a safe and effective option for highly vascular RPOC, especially in patients at risk of hemorrhage, with no adverse impact on fertility. Further prospective studies are recommended.<\/jats:p>","DOI":"10.3390\/jcm14228020","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T16:46:22Z","timestamp":1763138782000},"page":"8020","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical Outcomes After Hysteroscopic Removal of Retained Products of Conception with or Without Prior Uterine Artery Embolization"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5591-7903","authenticated-orcid":false,"given":"Eva","family":"Skuk","sequence":"first","affiliation":[{"name":"Department of Gynaecology, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia"},{"name":"Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7527-4231","authenticated-orcid":false,"given":"Polona","family":"Vihteli\u010d","sequence":"additional","affiliation":[{"name":"Clinical Institute of Radiology, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Popovi\u010d","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia"},{"name":"Clinical Institute of Radiology, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaja","family":"Kova\u010d","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6249-5799","authenticated-orcid":false,"given":"Ivan","family":"Verdenik","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia"},{"name":"Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nata\u0161a","family":"Kenda \u0160uster","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia"},{"name":"Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1111\/jog.14067","article-title":"Complications and reproductive outcome after uterine artery embolization for retained products of conception","volume":"45","author":"Kuramoto","year":"2019","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.jmig.2009.04.011","article-title":"Hysteroscopic management of residual trophoblastic tissue and reproductive outcome: A pilot study","volume":"16","author":"Faivre","year":"2009","journal-title":"J. Minim. Invasive Gynecol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1007\/s00270-016-1543-7","article-title":"Uterine artery embolization for retained products of conception with marked vascularity: A safe and efficient first-line treatment","volume":"40","author":"Bazeries","year":"2017","journal-title":"Cardiovasc. Intervent. Radiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s42155-020-00107-4","article-title":"The efficacy of uterine artery embolization with gelatin sponge for retained products of conception with bleeding and future pregnancy outcomes","volume":"3","author":"Kimura","year":"2020","journal-title":"CVIR Endovasc."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"397","DOI":"10.2478\/raon-2024-0037","article-title":"Emergency and prophylactic uterine artery embolization in gynecology and obstetrics\u2014A retrospective analysis","volume":"58","author":"Skuk","year":"2024","journal-title":"Radiol. Oncol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"100727","DOI":"10.1016\/j.tvir.2021.100727","article-title":"Uterine artery embolization for primary postpartum hemorrhage","volume":"24","author":"Brown","year":"2021","journal-title":"Tech. Vasc. Interv. Radiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3109\/13645706.2012.689768","article-title":"Pregnancy following uterine artery embolization: An update","volume":"22","author":"McLucas","year":"2013","journal-title":"Minim. Invasive Ther. Allied Technol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1097\/GCO.0b013e328338c179","article-title":"Impact of previous uterine artery embolization on fertility","volume":"22","author":"Berkane","year":"2010","journal-title":"Curr. Opin. Obstet. Gynecol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.jvir.2013.03.014","article-title":"Uterine artery embolization and its effect on fertility","volume":"24","author":"Mohan","year":"2013","journal-title":"J. Vasc. Interv. Radiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/j.jmig.2016.07.010","article-title":"Reproductive outcomes after hysteroscopic resection of retained products of conception","volume":"23","author":"Ikhena","year":"2016","journal-title":"J. Minim. Invasive Gynecol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.jmig.2011.08.003","article-title":"Hysteroscopic management of residual trophoblastic tissue is superior to ultrasound-guided curettage","volume":"18","author":"Rein","year":"2011","journal-title":"J. Minim. Invasive Gynecol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejogrb.2018.03.006","article-title":"Retained products of conception: What is the risk for recurrence on subsequent pregnancies?","volume":"224","author":"Smorgick","year":"2018","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1016\/j.ajog.2006.04.011","article-title":"Pregnancy after uterine artery embolization for leiomyomata: A series of 56 completed pregnancies","volume":"195","author":"Walker","year":"2006","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_14","first-page":"869","article-title":"Pregnancy after uterine artery embolization","volume":"100","author":"Goldberg","year":"2002","journal-title":"Obstet. Gynecol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.ijgo.2014.05.003","article-title":"A comparison of reproductive outcomes following hysteroscopic management versus dilatation and curettage of retained products of conception","volume":"127","author":"Melcer","year":"2014","journal-title":"Int. J. Gynaecol. Obstet."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/22\/8020\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T16:55:50Z","timestamp":1763139350000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/22\/8020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,12]]},"references-count":15,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2025,11]]}},"alternative-id":["jcm14228020"],"URL":"https:\/\/doi.org\/10.3390\/jcm14228020","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,12]]}}}