{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T13:19:41Z","timestamp":1763558381366,"version":"3.45.0"},"reference-count":14,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2025,11,16]],"date-time":"2025-11-16T00:00:00Z","timestamp":1763251200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Objective: To describe the clinical use of URO17\u00ae, a noninvasive, urine-based immunocytochemistry assay targeting Keratin 17 (K17), as an adjunct to conventional diagnostic methods for urothelial carcinoma. Materials and Methods: These illustrative cases summarize the real-world use of URO17\u00ae in diagnostic workflows for patients presenting with hematuria and those undergoing surveillance for non-muscle invasive bladder cancer (NMIBC). Urine samples were processed via standard immunocytochemistry and interpreted alongside cystoscopic, cytological, and radiographic findings. Discussion: URO17\u00ae was used as a complementary diagnostic tool to help guide clinical management. Negative results supported deferral of invasive procedures in selected patients, while positive findings prompted further evaluation when standard tests were inconclusive. Conclusions: In the seven illustrative cases presented, URO17\u00ae aided clinical decision-making as part of routine diagnostic and surveillance workflows. The test\u2019s integration with existing cytology processes supports its potential role as a noninvasive adjunct for evaluating patients with suspected or recurrent urothelial carcinoma.<\/jats:p>","DOI":"10.3390\/jcm14228108","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T12:55:31Z","timestamp":1763556931000},"page":"8108","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Experience with URO17\u00ae in the Diagnosis and Surveillance of Bladder Cancer"],"prefix":"10.3390","volume":"14","author":[{"given":"Shahram Shawn","family":"Gholami","sequence":"first","affiliation":[{"name":"Urology Association of Silicon Valley, San Jose, CA 95124, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehran","family":"Movassaghi","sequence":"additional","affiliation":[{"name":"Department of Urology, Providence Saint John\u2019s Health Center, Santa Monica, CA 90404, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sasha","family":"Homayoun","sequence":"additional","affiliation":[{"name":"Department of Mathematics, Southern New Hampshire University, Hooksett, NH 03106, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3966-5734","authenticated-orcid":false,"given":"Nikhil","family":"Vasdev","sequence":"additional","affiliation":[{"name":"Department of Urology, East and North Hertfordshire NHS Trust, Lister Hospital, Stevenage SG1 4AB, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,16]]},"reference":[{"key":"ref_1","unstructured":"American Cancer Society (2025, September 23). 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Urol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/bco2.50","article-title":"The Role of URO17\u2122 Biomarker to Enhance Diagnosis of Urothelial Cancer in New Hematuria Patients\u2014First European Data","volume":"2","author":"Vasdev","year":"2020","journal-title":"BJU Compass"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"76.e21","DOI":"10.1016\/j.urolonc.2024.02.012","article-title":"Evaluation of URO17\u00ae to Improve Non-Invasive Detection of Bladder Cancer","volume":"42","author":"Porten","year":"2024","journal-title":"Urol. 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Cancers, 17.","DOI":"10.3390\/cancers17132189"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1111\/bju.16828","article-title":"Enhanced Prognostic Value of Four-Tier Hybrid Grading System in Ta Non-Muscle-Invasive Bladder Cancer","volume":"136","author":"Ferro","year":"2025","journal-title":"BJU Int."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/22\/8108\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T13:16:16Z","timestamp":1763558176000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/22\/8108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,16]]},"references-count":14,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2025,11]]}},"alternative-id":["jcm14228108"],"URL":"https:\/\/doi.org\/10.3390\/jcm14228108","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2025,11,16]]}}}