{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T05:55:35Z","timestamp":1792130135215,"version":"4.4.0"},"reference-count":95,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2025,11,16]],"date-time":"2025-11-16T00:00:00Z","timestamp":1763251200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Polish Ministry of Science and Higher Education","award":["SUPB.RN.21.234"],"award-info":[{"award-number":["SUPB.RN.21.234"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Delirium is a common and serious neurocognitive disorder among hospitalised adults, which is associated with prolonged hospital stays, increased treatment costs, and increased mortality. Nurses, as healthcare professionals in constant contact with patients, play crucial roles in the early recognition, prevention, and management of delirium. This systematic review aimed to synthesise the evidence on nursing roles and interventions in the recognition, prevention, and treatment of delirium in hospitalised adult patients. Methods: A systematic literature search was conducted in PubMed\/MEDLINE, Scopus, and CINAHL\/EBSCO for studies published between January 2015 and August 2025. The protocol was registered in PROSPERO. Results: Out of the 3791 records identified, 39 met the inclusion criteria. Studies included randomised controlled trials, systematic reviews, and cross-sectional studies conducted in various hospital settings. Key nursing roles included early detection of risk factors, routine use of tools (e.g., CAM, CAM-ICU, 4AT), and implementation of multicomponent nonpharmacological prevention programs for patients with delirium. The evidence regarding the effectiveness of nurse-led interventions has been mixed: several studies reported reductions in delirium incidence and duration with early mobilisation, sleep promotion, cognitive stimulation, pain control and family involvement, whereas others reported no statistically significant effects. Conclusions: Routine screening, targeted nonpharmacological interventions, and interdisciplinary collaboration are essential for improving delirium-related outcomes. However, the findings should be interpreted with caution due to differences in the study design, variability in nursing practice across countries, and language restrictions that may have limited the scope of the review. Further high-quality studies are needed to clarify the impact of specific nursing-led strategies on delirium outcomes.<\/jats:p>","DOI":"10.3390\/jcm14228113","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T12:55:31Z","timestamp":1763556931000},"page":"8113","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Clinical Nursing Management of Adult Patients with Delirium in a Hospital Setting\u2014A Systematic Review"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2017-7052","authenticated-orcid":false,"given":"Anna","family":"Szewczak","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Nursing and Intensive Care, Medical University of Lublin, 20-059 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorota","family":"Siwicka","sequence":"additional","affiliation":[{"name":"I<sup>st<\/sup> Department of Anesthesiology and Intensive Care, Medical University of Lublin, 20-059 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jadwiga","family":"Klukow","sequence":"additional","affiliation":[{"name":"Institute of Clinical Sciences, Academy of Zamosc, 22-400 Zamosc, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2019-7819","authenticated-orcid":false,"given":"Joanna","family":"Czerwik-Marcinkowska","sequence":"additional","affiliation":[{"name":"Institute of Biology, Jan Kochanowski University of Kielce, 25-369 Kielce, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2039-2908","authenticated-orcid":false,"given":"Szymon","family":"Zmorzynski","sequence":"additional","affiliation":[{"name":"Institute of Human Sciences, Academy of Zamosc, 22-400 Zamosc, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,16]]},"reference":[{"key":"ref_1","unstructured":"W\u00f3jtowicz-Dacka, M., and Zaj\u0105c-Lamparska, L. (2007). O \u015awiadomo\u015bci. Wybrane zagadnienia. Wprow, Wydaw. UKW."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.ahj.2020.11.011","article-title":"Diagnosis, Prevention, and Management of Delirium in the Intensive Cardiac Care Unit","volume":"232","author":"Vicent","year":"2021","journal-title":"Am. Heart J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.mpmed.2024.07.002","article-title":"Delirium","volume":"52","author":"Prew","year":"2024","journal-title":"Medicine"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Association, E.D., and Society, A.D. (2014). The DSM-5 Criteria, Level of Arousal and Delirium Diagnosis: Inclusiveness Is Safer. BMC Med., 12.","DOI":"10.1186\/s12916-014-0141-2"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"El Sheikh, W.G., Sleem, B., Kobeissy, F., and Bizri, M. (2023). Biomarkers of Delirium and Relation to Dementia among the Elderly in the Intensive Care Unit: A Narrative Review. Biomark. Neuropsychiatry, 8.","DOI":"10.1016\/j.bionps.2023.100064"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/s41572-020-00223-4","article-title":"Delirium","volume":"6","author":"Wilson","year":"2020","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1056\/NEJMcp1605501","article-title":"Delirium in Hospitalized Older Adults","volume":"377","author":"Marcantonio","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Tieges, Z., Quinn, T., MacKenzie, L., Davis, D., Muniz-Terrera, G., MacLullich, A.M.J., and Shenkin, S.D. (2021). Association between Components of the Delirium Syndrome and Outcomes in Hospitalised Adults: A Systematic Review and Meta-Analysis. BMC Geriatr., 21.","DOI":"10.1186\/s12877-021-02095-z"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"973","DOI":"10.5498\/wjp.v13.i12.973","article-title":"Risk Factors, Preventive Interventions, Overlapping Symptoms, and Clinical Measures of Delirium in Elderly Patients","volume":"13","author":"Mei","year":"2023","journal-title":"World J. Psychiatry"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.3390\/nursrep14040219","article-title":"The Management and Prevention of Delirium in Elderly Patients Hospitalised in Intensive Care Units: A Systematic Review","volume":"14","year":"2024","journal-title":"Nurs. Rep."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1111\/jocn.15219","article-title":"Delirium Point Prevalence Studies in Inpatient Settings: A Systematic Review and Meta-analysis","volume":"29","author":"Koirala","year":"2020","journal-title":"J. Clin. Nurs."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1097\/ACO.0000000000001288","article-title":"Diagnosing Delirium in Perioperative and Intensive Care Medicine","volume":"36","author":"Goettel","year":"2023","journal-title":"Curr. Opin. Anesthesiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"102313","DOI":"10.1016\/j.arr.2024.102313","article-title":"Interventions to Prevent and Treat Delirium: An Umbrella Review of Randomized Controlled Trials","volume":"97","author":"Veronese","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e216370","DOI":"10.1001\/jamasurg.2021.6370","article-title":"Outcomes of a Delirium Prevention Program in Older Persons After Elective Surgery: A Stepped-Wedge Cluster Randomized Clinical Trial","volume":"157","author":"Deeken","year":"2022","journal-title":"JAMA Surg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1111\/pcn.13155","article-title":"Hospital-Wide Evaluation of Delirium Incidence in Adults under 65\u2009Years of Age","volume":"74","author":"Zipser","year":"2020","journal-title":"Psychiatry Clin. Neurosci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1146\/annurev-med-042220-013015","article-title":"Treatment of Delirium During Critical Illness","volume":"73","author":"Prendergast","year":"2022","journal-title":"Annu. Rev. Med."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"M\u0119drzycka-D\u0105browska, W., Lange, S., Religa, D., D\u0105browski, S., Friganovi\u0107, A., Oomen, B., and Krupa, S. (2022). Delirium in ICU Patients after Cardiac Arrest: A Scoping Review. J. Pers. Med., 12.","DOI":"10.3390\/jpm12071047"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.genhosppsych.2017.01.006","article-title":"Characterizing and Predicting Rates of Delirium across General Hospital Settings","volume":"46","author":"McCoy","year":"2017","journal-title":"Gen. Hosp. Psychiatry"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"104979","DOI":"10.1016\/j.ijnurstu.2024.104979","article-title":"Comparative Effectiveness of Delirium Recognition with and without a Clinical Decision Assessment System on Outcomes of Hospitalized Older Adults: Cluster Randomized Controlled Trial","volume":"162","author":"Wang","year":"2025","journal-title":"Int. J. Nurs. Stud."},{"key":"ref_20","unstructured":"Ram\u00edrez Echeverr\u00eda, M.d.L., Schoo, C., and Paul, M. (2017). Delirium, StatPearls Publishing."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"103749","DOI":"10.1016\/j.nepr.2023.103749","article-title":"Knowledge, Attitude and Practice Regarding Hypoactive Delirium among ICU Nurses: A Nationwide Cross-Sectional Study","volume":"72","author":"Yu","year":"2023","journal-title":"Nurse Educ. Pract."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"103757","DOI":"10.1016\/j.iccn.2024.103757","article-title":"Registered Nurses\u2019 Experiences of Caring for Patients with Hypoactive Delirium after Cardiac Surgery\u2014A Qualitative Study","volume":"84","author":"Kristensen","year":"2024","journal-title":"Intensive Crit. Care Nurs."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Fernandes, F., Santos, M., Anacleto, A.M., Jer\u00f3nimo, C., Ferreira, \u00d3., and Baixinho, C.L. (2024). Nursing Intervention to Prevent and Manage Delirium in Critically Ill Patients: A Scoping Review. Healthcare, 12.","DOI":"10.3390\/healthcare12111134"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e711","DOI":"10.1097\/CCM.0000000000006574","article-title":"A Focused Update to the Clinical Practice Guidelines for the Prevention and Management of Pain, Anxiety, Agitation\/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU","volume":"53","author":"Lewis","year":"2025","journal-title":"Crit. Care Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1097\/EJA.0000000000001876","article-title":"Update of the European Society of Anaesthesiology and Intensive Care Medicine Evidence-Based and Consensus-Based Guideline on Postoperative Delirium in Adult Patients","volume":"41","author":"Aldecoa","year":"2024","journal-title":"Eur. J. Anaesthesiol. EJA"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Lange, S., M\u0229drzycka-D\u0105browska, W., Tomaszek, L., Wujtewicz, M., and Krupa, S. (2023). Nurses\u2019 Knowledge, Barriers and Practice in the Care of Patients with Delirium in the Intensive Care Unit in Poland\u2014A Cross-Sectional Study. Front. Public Health, 11.","DOI":"10.3389\/fpubh.2023.1119526"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Kotfis, K., Zegan-Bara\u0144ska, M., \u017bukowski, M., Kusza, K., Kaczmarczyk, M., and Ely, E.W. (2017). Multicenter Assessment of Sedation and Delirium Practices in the Intensive Care Units in Poland\u2014Is This Common Practice in Eastern Europe?. BMC Anesthesiol., 17.","DOI":"10.1186\/s12871-017-0415-2"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Liang, S., Chau, J.P.C., Lo, S.H.S., Zhao, J., and Liu, W. (2022). Non-Pharmacological Delirium Prevention Practices among Critical Care Nurses: A Qualitative Study. BMC Nurs., 21.","DOI":"10.1186\/s12912-022-01019-5"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e1111","DOI":"10.1097\/CCM.0000000000002640","article-title":"Worldwide Survey of the \u201cAssessing Pain, Both Spontaneous Awakening and Breathing Trials, Choice of Drugs, Delirium Monitoring\/Management, Early Exercise\/Mobility, and Family Empowerment\u201d (ABCDEF) Bundle","volume":"45","author":"Morandi","year":"2017","journal-title":"Crit. Care Med."},{"key":"ref_30","first-page":"e3","article-title":"The nurse\u2019s role in preventing delirium in critically ill adult\/elderly patients","volume":"13","author":"Oliveira","year":"2022","journal-title":"Rev. Cuid."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e1230","DOI":"10.1002\/cl2.1230","article-title":"PRISMA2020: An R Package and Shiny App for Producing PRISMA 2020-Compliant Flow Diagrams, with Interactivity for Optimised Digital Transparency and Open Synthesis","volume":"18","author":"Haddaway","year":"2022","journal-title":"Campbell Syst. Rev."},{"key":"ref_32","first-page":"179","article-title":"Qualitative Research Synthesis: Methodological Guidance for Systematic Reviewers Utilizing Meta-Aggregation","volume":"13","author":"Lockwood","year":"2015","journal-title":"JBI Evid. Implement."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"j4008","DOI":"10.1136\/bmj.j4008","article-title":"AMSTAR 2: A Critical Appraisal Tool for Systematic Reviews That Include Randomised or Non-Randomised Studies of Healthcare Interventions, or Both","volume":"358","author":"Shea","year":"2017","journal-title":"BMJ"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"3692","DOI":"10.1111\/jan.14865","article-title":"Patients\u2019 Experiences of Delirium: A Systematic Review and Meta-Summary of Qualitative Research","volume":"77","author":"Baltes","year":"2021","journal-title":"J. Adv. Nurs."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Molitor, V., Busse, T.S., Giehl, C., Lauer, R., Otte, I.C., Vollmar, H.C., Th\u00fcrmann, P., Holle, B., and Palm, R. (2024). Educational Interventions Aimed at Improving Knowledge of Delirium among Nursing Home Staff\u2014A Realist Review. BMC Geriatr., 24.","DOI":"10.1186\/s12877-024-05213-9"},{"key":"ref_36","first-page":"CD013307","article-title":"Non-Pharmacological Interventions for Preventing Delirium in Hospitalised Non-ICU Patients","volume":"7","author":"Burton","year":"2021","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.aucc.2022.08.005","article-title":"A Nurse-Led Intervention to Reduce the Incidence and Duration of Delirium among Adults Admitted to Intensive Care: A Stepped-Wedge Cluster Randomised Trial","volume":"36","author":"Brennan","year":"2023","journal-title":"Aust. Crit. Care"},{"key":"ref_38","first-page":"CD005563","article-title":"Interventions for Preventing Delirium in Hospitalised Non-ICU Patients","volume":"2016","author":"Siddiqi","year":"2016","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/nur.22449","article-title":"Prioritization Patterns of Nurses in the Management of a Patient With Delirium: Results of a Q-Methodology Study","volume":"48","author":"Sist","year":"2025","journal-title":"Res. Nurs. Health"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1007\/s00134-021-06490-3","article-title":"Pharmacological and Non-Pharmacological Interventions to Prevent Delirium in Critically Ill Patients: A Systematic Review and Network Meta-Analysis","volume":"47","author":"Burry","year":"2021","journal-title":"Intensive Care Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1177\/14782715241301486","article-title":"Delirium Assessment, Management and Barriers to Effective Care across Scotland: A Secondary Analysis of Survey Data from World Delirium Awareness Day 2023","volume":"55","author":"Naeem","year":"2025","journal-title":"J. R. Coll. Physicians Edinb."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Kim, Y.H., Kim, N.Y., and Ryu, S. (2022). Effects of Non-Pharmacological Interventions for Preventing Delirium in General Ward Inpatients: A Systematic Review & Meta-Analysis of Randomized Controlled Trials. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0268024"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Lee, Y., Lee, J., Kim, J., and Jung, Y. (2021). Non-Pharmacological Nursing Interventions for Prevention and Treatment of Delirium in Hospitalized Adult Patients: Systematic Review of Randomized Controlled Trials. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph18168853"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Lange, S., M\u0119drzycka-D\u0105browska, W., Friganovic, A., Oomen, B., and Krupa, S. (2022). Non-Pharmacological Nursing Interventions to Prevent Delirium in ICU Patients\u2014An Umbrella Review with Implications for Evidence-Based Practice. J. Pers. Med., 12.","DOI":"10.3390\/jpm12050760"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00134-018-5452-x","article-title":"The Effectiveness of Non-Pharmacological Interventions in Reducing the Incidence and Duration of Delirium in Critically Ill Patients: A Systematic Review and Meta-Analysis","volume":"45","author":"Bannon","year":"2019","journal-title":"Intensive Care Med."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Rood, P.J.T., Ramnarain, D., Oldenbeuving, A.W., den Oudsten, B.L., Pouwels, S., van Loon, L.M., Teerenstra, S., Pickkers, P., de Vries, J., and van den Boogaard, M. (2023). The Impact of Non-Pharmacological Interventions on Delirium in Neurological Intensive Care Unit Patients: A Single-Center Interrupted Time Series Trial. J. Clin. Med., 12.","DOI":"10.3390\/jcm12185820"},{"key":"ref_47","first-page":"CD009783","article-title":"Interventions for Preventing Intensive Care Unit Delirium in Adults","volume":"11","author":"Herling","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s13019-021-01422-0","article-title":"The Effect of Multi-Component Interventions on the Incidence Rate, Severity, and Duration of Post Open Heart Surgery Delirium among Hospitalized Patients","volume":"16","author":"Tehranineshat","year":"2021","journal-title":"J. Cardiothorac. Surg."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.aucc.2022.04.006","article-title":"Effects of Nonpharmacological Interventions on Sleep Improvement and Delirium Prevention in Critically Ill Patients: A Systematic Review and Meta-Analysis","volume":"36","author":"Kang","year":"2023","journal-title":"Aust. Crit. Care"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"103925","DOI":"10.1016\/j.iccn.2024.103925","article-title":"The Impact of Non-Pharmacological Sleep Interventions on Delirium Prevention and Sleep Improvement in Postoperative ICU Patients: A Systematic Review and Network Meta-Analysis","volume":"87","author":"Li","year":"2025","journal-title":"Intensive Crit. Care Nurs."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"e70062","DOI":"10.1111\/nicc.70062","article-title":"Effects of Anxiety Focused Nursing Interventions on Anxiety, Cognitive Function and Delirium in Neurocritical Patients: A Non-Randomized Controlled Design","volume":"30","author":"Jang","year":"2025","journal-title":"Nurs. Crit. Care"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"103691","DOI":"10.1016\/j.iccn.2024.103691","article-title":"Dynamic Delirium\u2014Nursing Intervention to Reduce Delirium in Patients Critically Ill, a Randomized Control Trial","volume":"83","year":"2024","journal-title":"Intensive Crit. Care Nurs."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.jcrc.2020.08.019","article-title":"Non-Pharmacological Interventions to Reduce the Incidence and Duration of Delirium in Critically Ill Patients: A Systematic Review and Network Meta-Analysis","volume":"60","author":"Deng","year":"2020","journal-title":"J. Crit. Care"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"39","DOI":"10.4037\/ccn2015423","article-title":"Nonpharmacological Interventions to Prevent Delirium: An Evidence-Based Systematic Review","volume":"35","author":"Rivosecchi","year":"2015","journal-title":"Crit. Care Nurse"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"104584","DOI":"10.1016\/j.ijnurstu.2023.104584","article-title":"Non-Pharmacological Interventions to Prevent and Treat Delirium in Older People: An Overview of Systematic Reviews","volume":"148","author":"Zhao","year":"2023","journal-title":"Int. J. Nurs. Stud."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"104239","DOI":"10.1016\/j.ijnurstu.2022.104239","article-title":"Comparative Effectiveness of Non-Pharmacological Interventions for Preventing Delirium in Critically Ill Adults: A Systematic Review and Network Meta-Analysis","volume":"131","author":"Chen","year":"2022","journal-title":"Int. J. Nurs. Stud."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.aucc.2022.09.006","article-title":"Psychological Stress and Associated Factors in Caring for Patients with Delirium among Intensive Care Unit Nurses: A Cross-Sectional Study","volume":"36","author":"Wang","year":"2023","journal-title":"Aust. Crit. Care"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"103976","DOI":"10.1016\/j.iccn.2025.103976","article-title":"The Effectiveness of Family Participation Interventions for the Prevention of Delirium in Intensive Care Units: A Systematic Review","volume":"89","author":"Vitorino","year":"2025","journal-title":"Intensive Crit. Care Nurs."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"116245","DOI":"10.1016\/j.amjsurg.2025.116245","article-title":"Preventative Interventions for Postoperative Delirium after Intraabdominal Surgery\u2014A Systematic Review and Meta-Analysis of Randomized Trials","volume":"243","author":"Jensen","year":"2025","journal-title":"Am. J. Surg."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/wvn.12739","article-title":"Effectiveness of Nurse-led Non-pharmacological Interventions on Outcomes of Delirium in Adults: A Meta-analysis of Randomized Controlled Trials","volume":"21","author":"Wang","year":"2024","journal-title":"Worldviews Evid.-Based Nurs."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"e13321","DOI":"10.1111\/ijn.13321","article-title":"Effects of Sensory-Based Interventions on Delirium Prevention in Critically Ill Patients: A Systematic Review and Meta-Analysis","volume":"31","author":"Xu","year":"2025","journal-title":"Int. J. Nurs. Pract."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Pelin, M., and Sert, H. (2025). The Effect of Nursing Care Provided to Coronary Intensive Care Patients According to Their Circadian Rhythms on Sleep Quality, Pain, Anxiety, and Delirium: A Randomised Controlled Trial. BMC Nurs., 24.","DOI":"10.1186\/s12912-025-02793-8"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1111\/nicc.12780","article-title":"Effects of Non-Pharmacologic Prevention on Delirium in Critically Ill Patients: A Network Meta-Analysis","volume":"28","author":"Matsuura","year":"2023","journal-title":"Nurs. Crit. Care"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1177\/1078390320915250","article-title":"Perioperative Multicomponent Interdisciplinary Program Reduces Delirium Incidence in Elderly Patients With Hip Fracture","volume":"28","author":"Zhao","year":"2022","journal-title":"J. Am. Psychiatr. Nurses Assoc."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1111\/jocn.15973","article-title":"Evaluation of the Effectiveness of Delirium Prevention Care Protocol for the Patients with Hip Fracture: A Randomised Controlled Study","volume":"31","author":"Unal","year":"2022","journal-title":"J. Clin. Nurs."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"280","DOI":"10.4103\/JETS.JETS_137_17","article-title":"Emergency Department Interventions and Their Effect on Delirium\u2019s Natural Course: The Folly May Be in the Foley","volume":"12","author":"Noel","year":"2019","journal-title":"J. Emergencies Trauma Shock"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1001\/jama.2019.8766","article-title":"Effect of Flexible Family Visitation on Delirium Among Patients in the Intensive Care Unit: The ICU Visits Randomized Clinical Trial","volume":"322","author":"Rosa","year":"2019","journal-title":"JAMA"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.jcrc.2021.12.015","article-title":"Effectiveness of Combined Non-Pharmacological Interventions in the Prevention of Delirium in Critically Ill Patients: A Randomized Clinical Trial","volume":"68","author":"Faustino","year":"2022","journal-title":"J. Crit. Care"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"479","DOI":"10.4266\/acc.2023.00990","article-title":"The Effects of Environmental Interventions for Delirium in Critically Ill Surgical Patients","volume":"38","author":"Lee","year":"2023","journal-title":"Acute Crit. Care"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"e5872","DOI":"10.1002\/gps.5872","article-title":"Delirium Is Significantly Associated with Hospital Frailty Risk Score Derived from Administrative Data","volume":"38","author":"Lim","year":"2023","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Liu, X., Wang, Y., Wu, J., Ye, C., Ma, D., and Wang, E. (2023). Emergence Delirium and Postoperative Delirium Associated with High Plasma NfL and GFAP: An Observational Study. Front. Med., 10.","DOI":"10.3389\/fmed.2023.1107369"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1001\/jamaneurol.2020.2273","article-title":"Association of Delirium With Long-Term Cognitive Decline: A Meta-Analysis","volume":"77","author":"Goldberg","year":"2020","journal-title":"JAMA Neurol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"33","DOI":"10.12688\/hrbopenres.14081.1","article-title":"Nurses\u2019 Usage of Validated Tools to Assess for Delirium in General Acute Care Settings: A Scoping Review Protocol","volume":"8","author":"Boyd","year":"2025","journal-title":"HRB Open Res."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Al Huraizi, A.R., Al-Maqbali, J.S., Al Farsi, R.S., Al Zeedy, K., Al-Saadi, T., Al-Hamadani, N., and Al Alawi, A.M. (2023). Delirium and Its Association with Short- and Long-Term Health Outcomes in Medically Admitted Patients: A Prospective Study. J. Clin. Med., 12.","DOI":"10.3390\/jcm12165346"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.jcrc.2016.05.028","article-title":"Routine Delirium Monitoring Is Independently Associated with a Reduction of Hospital Mortality in Critically Ill Surgical Patients: A Prospective, Observational Cohort Study","volume":"35","author":"Luetz","year":"2016","journal-title":"J. Crit. Care"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.mpmed.2016.11.002","article-title":"Confusion and Delirium in the Acute Setting","volume":"45","author":"Bates","year":"2017","journal-title":"Medicine"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1007\/s00134-021-06503-1","article-title":"Delirium in Critical Illness: Clinical Manifestations, Outcomes, and Management","volume":"47","author":"Stollings","year":"2021","journal-title":"Intensive Care Med."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"afae129","DOI":"10.1093\/ageing\/afae129","article-title":"A World-Wide Study on Delirium Assessments and Presence of Protocols","volume":"53","author":"Nydahl","year":"2024","journal-title":"Age Ageing"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"164","DOI":"10.3390\/nursrep11010016","article-title":"Nurses\u2019 Experience of Caring for Patients with Delirium: Systematic Review and Qualitative Evidence Synthesis","volume":"11","author":"Thomas","year":"2021","journal-title":"Nurs. Rep."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"e379","DOI":"10.1161\/CIR.0000000000000909","article-title":"Prevention of Complications in the Cardiac Intensive Care Unit: A Scientific Statement From the American Heart Association","volume":"142","author":"Fordyce","year":"2020","journal-title":"Circulation"},{"key":"ref_81","unstructured":"Instituto Nacional para la Excelencia en la Salud y la Atenci\u00f3n (NICE) (2023). Delirium: Prevention, Diagnosis and Management in Hospital and Long-Term Care. NICE Guidelines, Instituto Nacional para la Excelencia en la Salud y la Atenci\u00f3n (NICE)."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"\u00d6zt\u00fcrk, Z., Kaya, M., Aksoy, M., and Karaman \u00d6zl\u00fc, Z. (2025). Investigation of the Factors Affecting Delirium Evaluation by Intensive Care Nurses: A Cross-Sectional Descriptive Study. BMC Nurs., 24.","DOI":"10.1186\/s12912-025-03638-0"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1097\/CCM.0000000000003402","article-title":"Incidence and Prevalence of Delirium Subtypes in an Adult ICU: A Systematic Review and Meta-Analysis","volume":"46","author":"Krewulak","year":"2018","journal-title":"Crit. Care Med."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.jcrc.2020.01.017","article-title":"Risk Factors and Outcomes among Delirium Subtypes in Adult ICUs: A Systematic Review","volume":"56","author":"Krewulak","year":"2020","journal-title":"J. Crit. Care"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"e480","DOI":"10.1097\/CCM.0000000000004313","article-title":"Association of Hypoactive and Hyperactive Delirium With Cognitive Function After Critical Illness","volume":"48","author":"Hayhurst","year":"2020","journal-title":"Crit. Care Med."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Ragheb, J., Norcott, A., Benn, L., Shah, N., McKinney, A., Min, L., and Vlisides, P.E. (2023). Barriers to Delirium Screening and Management during Hospital Admission: A Qualitative Analysis of Inpatient Nursing Perspectives. BMC Health Serv. Res., 23.","DOI":"10.1186\/s12913-023-09681-4"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"e825","DOI":"10.1097\/CCM.0000000000003299","article-title":"Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation\/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU","volume":"46","author":"Devlin","year":"2018","journal-title":"Crit. Care Med."},{"key":"ref_88","first-page":"101088","article-title":"The Development of a Family-Led Novel Intervention for Delirium Prevention and Management in the Adult Intensive Care Unit: A Co-Design Qualitative Study","volume":"38","author":"Johnson","year":"2025","journal-title":"Aust. Crit. Care Off. J. Confed. Aust. Crit. Care Nurses"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1080\/21551197.2018.1470055","article-title":"Serious Consequences of Malnutrition and Delirium in Frail Older Patients","volume":"37","author":"Rosted","year":"2018","journal-title":"J. Nutr. Gerontol. Geriatr."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/j.jamda.2020.09.032","article-title":"Visual and Hearing Impairment Are Associated With Delirium in Hospitalized Patients: Results of a Multisite Prevalence Study","volume":"22","author":"Morandi","year":"2021","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"791","DOI":"10.2147\/NSS.S286375","article-title":"Effects of Patient-Directed Interactive Music Therapy on Sleep Quality in Postoperative Elderly Patients: A Randomized-Controlled Trial","volume":"12","author":"Kim","year":"2020","journal-title":"Nat. Sci. Sleep"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1164\/rccm.202106-1475ED","article-title":"Nonpharmacological Interventions in Delirium: The Law of the Handicap of a Head Start","volume":"204","author":"Slooter","year":"2021","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1164\/rccm.202101-0082OC","article-title":"The Impact of Nursing Delirium Preventive Interventions in the ICU: A Multicenter Cluster-Randomized Controlled Clinical Trial","volume":"204","author":"Rood","year":"2021","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1001\/jamainternmed.2014.7779","article-title":"Effectiveness of Multicomponent Nonpharmacological Delirium Interventions: A Meta-Analysis","volume":"175","author":"Hshieh","year":"2015","journal-title":"JAMA Intern. Med."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: An updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/22\/8113\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T13:17:02Z","timestamp":1763558222000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/22\/8113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,16]]},"references-count":95,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2025,11]]}},"alternative-id":["jcm14228113"],"URL":"https:\/\/doi.org\/10.3390\/jcm14228113","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,16]]}}}