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According to statistics, recurrent implantation failure (RIF), for which different definitions have been proposed, is estimated to affect about 10\u201325% of women undergoing in vitro fertilization (IVF). RIF is a complex condition with overlapping causes. The primary objective of this review is to explore factors such as gamete and embryo quality, chromosomal abnormalities, uterine environment, endometrial receptivity, immune cell biomarkers, and microbiota dysregulation to better understand and overcome RIF challenges. It also highlights the significance of comprehensive evaluations of novel therapies, such as activated autologous platelet-rich plasma (PRP) or peripheral blood mononuclear cell (PBMC) insemination, on pregnancy outcomes in patients with RIF.<\/jats:p>","DOI":"10.3390\/jcm14228163","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T12:55:31Z","timestamp":1763556931000},"page":"8163","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Implantation Failure: Where to Look Up?"],"prefix":"10.3390","volume":"14","author":[{"given":"Antonis","family":"Makrigiannakis","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, University Hospital and School of Medicine, University of Crete, 71003 Heraklion, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatjana","family":"Motrenko","sequence":"additional","affiliation":[{"name":"Human Reproduction Center, 85310 Budva, Montenegro"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9685-7633","authenticated-orcid":false,"given":"Marwa","family":"Lahimer","sequence":"additional","affiliation":[{"name":"IVF & Reproductive Genetics, University Hospital and School of Medicine, Picardie University Jules Verne, Centre Hospital-Universitaire Amiens Sud, 80000 Amiens, France"},{"name":"PERITOX-(UMR-I 01), UPJV\/INERIS, UPJV, CURS, Chemin du Thil, 80025 Amiens, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2413-9176","authenticated-orcid":false,"given":"Fanourios Ioannis","family":"Makrygiannakis","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University Hospital and School of Medicine, University of Crete, 71003 Heraklion, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalie","family":"Cabry","sequence":"additional","affiliation":[{"name":"IVF & Reproductive Genetics, University Hospital and School of Medicine, Picardie University Jules Verne, Centre Hospital-Universitaire Amiens Sud, 80000 Amiens, France"},{"name":"PERITOX-(UMR-I 01), UPJV\/INERIS, UPJV, CURS, Chemin du Thil, 80025 Amiens, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4645-5804","authenticated-orcid":false,"given":"Jan","family":"Tesarik","sequence":"additional","affiliation":[{"name":"MARGen Clinic, 18002 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moncef","family":"Benkhalifa","sequence":"additional","affiliation":[{"name":"IVF & Reproductive Genetics, University Hospital and School of Medicine, Picardie University Jules Verne, Centre Hospital-Universitaire Amiens Sud, 80000 Amiens, France"},{"name":"PERITOX-(UMR-I 01), UPJV\/INERIS, UPJV, CURS, Chemin du Thil, 80025 Amiens, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.rbmo.2013.08.011","article-title":"Recurrent implantation failure: Definition and management","volume":"28","author":"Coughlan","year":"2014","journal-title":"Reprod. 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