{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:27:08Z","timestamp":1787066828575,"version":"build-2736575974"},"reference-count":35,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: The success of orthopaedic surgery is fundamentally biological, yet the synergistic effect of smoking and comorbidities on surgical outcomes is not well quantified. We hypothesised that active smoking multiplies the risk conferred by common comorbidities. Methods: In this retrospective cohort study, we analysed 3123 orthopaedic procedures from 2020 to 2024. Patients were stratified by comorbidity (diabetes, anemia, hepatic dysfunction, chronic venous disease) and smoking status. Primary outcomes were orthopaedic-specific complications, including non-union, periprosthetic joint infection (PJI), and revision surgery. We used multivariate logistic regression to calculate adjusted odds ratios (aORs) and formal tests for interaction to quantify synergy. Results: A significant synergistic effect was observed. In analyses adjusted for age, sex, and procedure acuity, diabetic smokers had significantly higher rates of non-union (8.6% vs. 3.3%; aOR 3.0, 95% CI 1.1\u20138.2), periprosthetic joint infection (8.2% vs. 2.8%; aOR 3.1, 95% CI 1.1\u20138.9), and revision surgery (12.2% vs. 5.0%; aOR 2.7, 95% CI 1.2\u20136.1). Significant interaction effects confirmed this synergy. Smokers with hepatic dysfunction had higher haematoma rates, while smoking with severe anemia was associated with markedly increased mortality (5.0%; aOR 8.9, 95% CI 1.8\u201343.1). Former smokers\u2019 outcomes were consistently intermediate between active and non-smokers. For example, in the diabetic cohort, the adjusted odds of non-union were elevated for both former (aOR 2.1, 95% CI 0.8\u20135.5) and active smokers (aOR 3.0, 95% CI 1.1\u20138.2) compared to non-smokers (reference), demonstrating a gradient of risk. Conclusions: Smoking is associated with a multiplicative increase in comorbidity risk, creating a distinct high-risk phenotype that severely compromises healing. These findings strongly support that verified smoking cessation should be a foundational component of preoperative optimisation before elective orthopaedic surgery.<\/jats:p>","DOI":"10.3390\/jcm14228217","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T10:30:59Z","timestamp":1763634659000},"page":"8217","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Smoking Amplifies Comorbidity-Associated Risk in Orthopaedic Surgery: A Multiplicative Interaction"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3558-2856","authenticated-orcid":false,"given":"Edith Simona","family":"Iano\u0219i","sequence":"first","affiliation":[{"name":"Department of Pulmonology, University of Medicine, Pharmacy, Technology and Sciences \u201cGeorge Emil Palade\u201d of T\u00e2rgu Mure\u0219, 540139 T\u00e2rgu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5193-5727","authenticated-orcid":false,"given":"Daria-Maria","family":"Ro\u0219u","sequence":"additional","affiliation":[{"name":"Faculty of General Medicine, University of Medicine, Pharmacy, Science and Technology \u201cGeorge Emil Palade\u201d of T\u00e2rgu Mure\u0219, 540139 T\u00e2rgu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9847-1414","authenticated-orcid":false,"given":"Arpad","family":"Solyom","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic and Traumatology Surgery, University of Medicine, Pharmacy, Science and Technology \u201cGeorge Emil Palade\u201d of T\u00e2rgu Mure\u0219, 540139 T\u00e2rgu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca Liana","family":"Grigorescu","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care, University of Medicine, Pharmacy, Science and Technology \u201cGeorge Emil Palade\u201d of T\u00e2rgu Mure\u0219, 540139 T\u00e2rgu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1695-6990","authenticated-orcid":false,"given":"Mara","family":"Vultur","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, University of Medicine, Pharmacy, Technology and Sciences \u201cGeorge Emil Palade\u201d of T\u00e2rgu Mure\u0219, 540139 T\u00e2rgu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7910-0123","authenticated-orcid":false,"given":"Maria Beatrice","family":"Iano\u0219i","sequence":"additional","affiliation":[{"name":"Pulmonology Clinic, Mures, County Clinical Hospital, 540011 T\u00e2rgu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1097\/00003086-199810001-00003","article-title":"The cell and molecular biology of fracture healing","volume":"355","author":"Einhorn","year":"1998","journal-title":"Clin. 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