{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:37:36Z","timestamp":1791463056086,"version":"4.3.4"},"reference-count":18,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2025,11,23]],"date-time":"2025-11-23T00:00:00Z","timestamp":1763856000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u201cVictor Babes\u201d University of Medicine and Pharmacy, Timisoara"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Diabetic neuropathy (DN) may impair balance and gait, increasing the risk of falls in elderly patients with type 2 diabetes mellitus (T2DM). This study aimed to evaluate whether the presence and severity of DN are associated with balance and mobility impairment as well as with increased fear of falling in patients with T2DM. Methods: A total of 124 adults with T2DM underwent neuropathy assessment with the Michigan Neuropathy Screening Instrument (MNSI) and sudomotor testing (SUDOSCAN). Balance and fall risk were evaluated using the Berg Balance Scale (BBS), Timed Up and Go (TUG), Falls Efficacy Scale\u2014International (FES-I), and Fear of Falling Questionnaire\u2014Revised (FFQ-R). Comparison of parameters between patients with vs. without DN, correlations, and multivariable linear regressions (DN components as predictors) were performed. Results: Compared with those without DN, participants with DN had higher FES-I (31.0 vs. 21.0) and FFQ-R (56.0 vs. 42.0) scores and lower BBS (42.0 vs. 46.0). TUG did not differ significantly (11.8 vs. 11.25 s). In multivariable models, higher MNSI questionnaire and objective scores independently predicted lower BBS (\u03b2 = \u22120.74 and \u22121.1, respectively) while only the MNSI questionnaire predicted higher TUG (\u03b2 = 0.43). For fear of falling, the MNSI questionnaire predicted higher FES-I (\u03b2 = 1.66) and both MNSI components predicted higher FFQ-R (\u03b2 = 2.31 and 1.7, respectively). Leg SUDOSCAN values were not associated with BBS, TUG, FES-I, or FFQ-R. Conclusions: DN is associated with impaired balance and greater fear of falling. Neuropathy burden, particularly patient-reported symptoms, relates to worse performance and confidence, whereas sudomotor impairment alone does not.<\/jats:p>","DOI":"10.3390\/jcm14238323","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T16:31:54Z","timestamp":1764088314000},"page":"8323","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Associations Between Diabetic Neuropathy and Balance Impairments in Patients with Type 2 Diabetes: A Cross-Sectional Study"],"prefix":"10.3390","volume":"14","author":[{"given":"Bianca","family":"Iliescu","sequence":"first","affiliation":[{"name":"Doctoral School of Medicine, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"},{"name":"Sebes Municipal Hospital, 515800 Sebes, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6952-2171","authenticated-orcid":false,"given":"Andreea","family":"Herascu","sequence":"additional","affiliation":[{"name":"Doctoral School of Medicine, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"},{"name":"Centre for Molecular Research in Nephrology and Vascular Disease, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"},{"name":"Department of Diabetes, \u201cPius Brinzeu\u201d Emergency Hospital, 300736 Timisoara, Romania"},{"name":"Second Department of Internal Medicine, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5204-6954","authenticated-orcid":false,"given":"Laura","family":"Gaita","sequence":"additional","affiliation":[{"name":"Centre for Molecular Research in Nephrology and Vascular Disease, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"},{"name":"Department of Diabetes, \u201cPius Brinzeu\u201d Emergency Hospital, 300736 Timisoara, Romania"},{"name":"Second Department of Internal Medicine, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vlad-Florian","family":"Avram","sequence":"additional","affiliation":[{"name":"Centre for Molecular Research in Nephrology and Vascular Disease, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"},{"name":"Department of Diabetes, \u201cPius Brinzeu\u201d Emergency Hospital, 300736 Timisoara, Romania"},{"name":"Second Department of Internal Medicine, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0993-6206","authenticated-orcid":false,"given":"Bogdan","family":"Timar","sequence":"additional","affiliation":[{"name":"Centre for Molecular Research in Nephrology and Vascular Disease, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"},{"name":"Department of Diabetes, \u201cPius Brinzeu\u201d Emergency Hospital, 300736 Timisoara, Romania"},{"name":"Second Department of Internal Medicine, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/s41572-019-0092-1","article-title":"Diabetic neuropathy","volume":"5","author":"Feldman","year":"2019","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.pcd.2019.12.005","article-title":"Prevalence of peripheral neuropathy in patients with diabetes: A systematic review and meta-analysis","volume":"14","author":"Sun","year":"2020","journal-title":"Prim. Care Diabetes"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.mpmed.2022.08.008","article-title":"Diabetes in the elderly","volume":"50","author":"Abdelhafiz","year":"2022","journal-title":"Medicine"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"100053","DOI":"10.1016\/j.endmts.2020.100053","article-title":"Prevalence and risk factors of diabetic peripheral neuropathy in a diabetics cohort: Register initiative \u201cdiabetes and nerves\u201d","volume":"1","author":"Pfannkuche","year":"2020","journal-title":"Endocr. Metab. Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.4158\/EP171794.RA","article-title":"Aging, Diabetes, and Falls","volume":"23","author":"Vinik","year":"2017","journal-title":"Endocr. Pract."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s43465-019-00037-x","article-title":"Falls in Older Adults are Serious","volume":"54","author":"Vaishya","year":"2020","journal-title":"Indian J. Orthop."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.2147\/DMSO.S410834","article-title":"The Association Between Sarcopenia and Diabetes: From Pathophysiology Mechanism to Therapeutic Strategy","volume":"16","author":"Chen","year":"2023","journal-title":"Diabetes Metab. Syndr. Obesity Targets Ther."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"311","DOI":"10.4239\/wjd.v10.i5.311","article-title":"Association between sarcopenic obesity and higher risk of type 2 diabetes in adults: A systematic review and meta-analysis","volume":"10","author":"Khadra","year":"2019","journal-title":"World J. Diabetes"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.gaitpost.2024.04.033","article-title":"Sarcopenia in older adults is associated with static postural control, fear of falling and fall risk: A study of Romberg test","volume":"112","author":"Hu","year":"2024","journal-title":"Gait Posture"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1177\/1932296821997921","article-title":"The Impact of Diabetic Neuropathy on Activities of Daily Living, Postural Balance and Risk of Falls\u2014A Systematic Review","volume":"16","author":"Khan","year":"2021","journal-title":"J. Diabetes Sci. Technol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/s41392-025-02175-1","article-title":"Diabetic neuropathy: Cutting-edge research and future directions","volume":"10","author":"Yang","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Reeves, N.D., Orlando, G., and Brown, S.J. (2021). Sensory-Motor Mechanisms Increasing Falls Risk in Diabetic Peripheral Neuropathy. Medicina, 57.","DOI":"10.3390\/medicina57050457"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/dmrr.2257","article-title":"Motor dysfunction in diabetes","volume":"28","author":"Andersen","year":"2012","journal-title":"Diabetes Metab. Res. Rev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.2337\/dc14-0955","article-title":"Contributory Factors to Unsteadiness During Walking Up and Down Stairs in Patients With Diabetic Peripheral Neuropathy","volume":"37","author":"Handsaker","year":"2014","journal-title":"Diabetes Care"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.1016\/j.jbiomech.2014.10.005","article-title":"Do patients with diabetic neuropathy use a higher proportion of their maximum strength when walking?","volume":"47","author":"Brown","year":"2014","journal-title":"J. Biomech."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1016\/j.apmr.2013.06.007","article-title":"Postural Control and Functional Strength in Patients With Type 2 Diabetes Mellitus With and Without Peripheral Neuropathy","volume":"94","author":"Vaz","year":"2013","journal-title":"Arch. Phys. Med. Rehabilitation"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.3390\/clinpract14050161","article-title":"Balance, Gait, Functionality and Fall Occurrence in Adults and Older Adults with Type 2 Diabetes Mellitus and Associated Peripheral Neuropathy","volume":"14","author":"Tavares","year":"2024","journal-title":"Clin. Pract."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Riandini, T., Khoo, E.Y.H., Tai, B.C., Tavintharan, S., Phua, M.S.L.A., Chandran, K., Hwang, S.W., and Venkataraman, K. (2020). Fall Risk and Balance Confidence in Patients With Diabetic Peripheral Neuropathy: An Observational Study. Front. Endocrinol., 11.","DOI":"10.3389\/fendo.2020.573804"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/23\/8323\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T16:48:52Z","timestamp":1764089332000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/23\/8323"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,23]]},"references-count":18,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["jcm14238323"],"URL":"https:\/\/doi.org\/10.3390\/jcm14238323","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,23]]}}}