{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:56:12Z","timestamp":1787316972357,"version":"build-2736575974"},"reference-count":34,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FIIB HUIS-HUEN"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Objectives: To estimate the prevalence of psoriatic arthritis (PsA) and associated factors in patients with moderate-to-severe psoriasis. Methods: Retrospective, single-center study of a cohort of psoriasis patients in standard follow-up in a dermatology department from July 2008 to January 2024. Patients \u226518 years with moderate-to-severe psoriasis were included and classified into three groups according to the treatment received: group 1, biologics or small molecules with or without conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs); group 2, only csDMARDS; and group 3, non-pharmacological treatments. Demographic and clinical variables were collected. The prevalence of PsA was estimated with its 95% confidence interval (CI). The cumulative incidence of PsA was analyzed across groups, and logistic regression models were built. Results: The study population comprised 308 patients (67.2%, 22.7%, 10% in groups 1, 2, and 3, respectively). Differences between the groups were observed in severity of psoriasis, weight, smoking status, and dyslipidemia (p &lt; 0.05). The prevalence of PsA was 11.7% (95% CI, 8.1\u201315.3), with most patients in group 1. This group had a higher risk of PsA following diagnosis of psoriasis or initiation of treatment. Belonging to groups 2 and 3 had a smaller effect than belonging to group 1 in the development of PsA; nail involvement and obstructive sleep apnea (OSA) were associated with development of PsA (p &lt; 0.05). Conclusions: The prevalence estimate was lower than previous estimates, probably owing to the increased use of biologics. Nail involvement and OSA were associated with PsA.<\/jats:p>","DOI":"10.3390\/jcm14238359","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T17:31:34Z","timestamp":1764091894000},"page":"8359","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prevalence of Psoriatic Arthritis in Patients with Moderate-to-Severe Psoriasis in the Era of Biologics and Small Molecule Therapies"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4952-6992","authenticated-orcid":false,"given":"Cristina","family":"Vergara-Dangond","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Hospital Universitario Infanta Sof\u00eda, 28702 Madrid, Spain"},{"name":"Department of Medicine, Faculty of Medicine, Health and Sports, Universidad Europea de Madrid, 28670 Madrid, Spain"},{"name":"FIIB HUIS-HUHEN, 28702 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Cobo-Ib\u00e1\u00f1ez","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Hospital Universitario Infanta Sof\u00eda, 28702 Madrid, Spain"},{"name":"Department of Medicine, Faculty of Medicine, Health and Sports, Universidad Europea de Madrid, 28670 Madrid, Spain"},{"name":"FIIB HUIS-HUHEN, 28702 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Cueva-N\u00e1jera","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Hospital Universitario Infanta Sof\u00eda, 28702 Madrid, Spain"},{"name":"FIIB HUIS-HUHEN, 28702 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Valverde-Garrido","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Health and Sports, Universidad Europea de Madrid, 28670 Madrid, Spain"},{"name":"FIIB HUIS-HUHEN, 28702 Madrid, Spain"},{"name":"Department of Dermatology, Hospital Universitario Infanta Sof\u00eda, 28702 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2972-4128","authenticated-orcid":false,"given":"Cristina","family":"Garc\u00eda-Yubero","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Health and Sports, Universidad Europea de Madrid, 28670 Madrid, Spain"},{"name":"FIIB HUIS-HUHEN, 28702 Madrid, Spain"},{"name":"Department of Pharmacy, Hospital Universitario Infanta Sof\u00eda, 28702 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Trives-Folguera","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Hospital Universitario Infanta Sof\u00eda, 28702 Madrid, Spain"},{"name":"Department of Medicine, Faculty of Medicine, Health and Sports, Universidad Europea de Madrid, 28670 Madrid, Spain"},{"name":"FIIB HUIS-HUHEN, 28702 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0911-1810","authenticated-orcid":false,"given":"Beatriz","family":"Paredes-Romero","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Hospital Universitario Infanta Sof\u00eda, 28702 Madrid, Spain"},{"name":"Department of Medicine, Faculty of Medicine, Health and Sports, Universidad Europea de Madrid, 28670 Madrid, Spain"},{"name":"FIIB HUIS-HUHEN, 28702 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Victoria","family":"Esteban-V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Hospital Universitario Infanta Sof\u00eda, 28702 Madrid, Spain"},{"name":"Department of Medicine, Faculty of Medicine, Health and Sports, Universidad Europea de Madrid, 28670 Madrid, Spain"},{"name":"FIIB HUIS-HUHEN, 28702 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liz","family":"Romero-Bogado","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Hospital Universitario Infanta Sof\u00eda, 28702 Madrid, Spain"},{"name":"Department of Medicine, Faculty of Medicine, Health and Sports, Universidad Europea de Madrid, 28670 Madrid, Spain"},{"name":"FIIB HUIS-HUHEN, 28702 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"De La C\u00e1mara-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Hospital Universitario Infanta Sof\u00eda, 28702 Madrid, Spain"},{"name":"Department of Medicine, Faculty of Medicine, Health and Sports, Universidad Europea de Madrid, 28670 Madrid, Spain"},{"name":"FIIB HUIS-HUHEN, 28702 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1617-4454","authenticated-orcid":false,"given":"Martina","family":"Steiner","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Hospital Universitario Infanta Sof\u00eda, 28702 Madrid, Spain"},{"name":"Department of Medicine, Faculty of Medicine, Health and Sports, Universidad Europea de Madrid, 28670 Madrid, Spain"},{"name":"FIIB HUIS-HUHEN, 28702 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2277-6814","authenticated-orcid":false,"given":"Patricia","family":"Richi-Alberti","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Hospital Universitario Infanta Sof\u00eda, 28702 Madrid, Spain"},{"name":"Department of Medicine, Faculty of Medicine, Health and Sports, Universidad Europea de Madrid, 28670 Madrid, Spain"},{"name":"FIIB HUIS-HUHEN, 28702 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Valeria","family":"Acosta-Alfaro","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Hospital Universitario Infanta Sof\u00eda, 28702 Madrid, Spain"},{"name":"FIIB HUIS-HUHEN, 28702 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iolanda","family":"Prats","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Health and Sports, Universidad Europea de Madrid, 28670 Madrid, Spain"},{"name":"FIIB HUIS-HUHEN, 28702 Madrid, Spain"},{"name":"Department of Dermatology, Hospital Universitario Infanta Sof\u00eda, 28702 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2758-2085","authenticated-orcid":false,"given":"Santiago","family":"Mu\u00f1oz-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Hospital Universitario Infanta Sof\u00eda, 28702 Madrid, Spain"},{"name":"Department of Medicine, Faculty of Medicine, Health and Sports, Universidad Europea de Madrid, 28670 Madrid, Spain"},{"name":"FIIB HUIS-HUHEN, 28702 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,25]]},"reference":[{"key":"ref_1","first-page":"504","article-title":"Prevalence of psoriasis in Spain in the age of biologics","volume":"105","author":"Carrascosa","year":"2014","journal-title":"Actas Dermo-Sifiliogr."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"ii14","DOI":"10.1136\/ard.2004.032482","article-title":"Psoriatic arthritis: Epidemiology, clinical features, course, and outcome","volume":"64","author":"Gladman","year":"2005","journal-title":"Ann. 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