{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T20:42:58Z","timestamp":1789504978070,"version":"build-2803163510"},"reference-count":21,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Reconstruction of membranous urethral strictures poses significant surgical challenges, including risks of urinary incontinence and erectile dysfunction. Optilume drug-coated balloon dilation (DCBD) is a minimally invasive treatment for short, recurrent bulbar urethral strictures, but its application in strictures involving the sphincteric urethra remains controversial. This study aims to evaluate the safety, efficacy, and impact on continence of DCBD in membranous urethral strictures involving the male sphincter. Methods: A retrospective analysis was conducted on 53 consecutive patients with urethral strictures involving the sphincteric urethra, treated with Optilume DCBD between June 2021 and June 2025 at a tertiary center. After preoperative imaging, dilation to 20 Fr, then DCBD (30 Fr, 10 bar, 10 min) were performed. We assessed anatomical success (\u226518 Fr as per cystoscopy\/calibration), freedom from re-intervention, and continence status. Patients with neurological conditions or urinary infections were excluded. Results: The cohort included 35 membranous urethral strictures and 18 vesicourethral anastomosis stenoses that extended into the sphincter. The median follow-up was 13.3 months. At last follow-up, 66.6% and 65.6% of patients in both groups were free from recurrence and re-intervention with satisfactory voiding. No de novo incontinence was observed; two patients with prior post-prostatectomy incontinence remained incontinent. The median age was 68 years; median prior interventions were 2.5, and median stricture length was 3 cm. Conclusions: Optilume DCBD appears to be a safe and effective option for membranous urethral strictures involving the sphincter, without inducing de novo incontinence. Although not a replacement for reconstruction, it offers a minimally invasive alternative for selected patients.<\/jats:p>","DOI":"10.3390\/jcm14238369","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T17:31:34Z","timestamp":1764091894000},"page":"8369","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Optilume Drug-Coated Balloon Dilation for Male Sphincteric (Membranous) Urethral Strictures: 53 Consecutive Cases"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3606-2841","authenticated-orcid":false,"given":"Lukas Andrius","family":"Jelisejevas","sequence":"first","affiliation":[{"name":"Department of Urology, Medical University Innsbruck, 6020 Innsbruck, Tyrol, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2964-1544","authenticated-orcid":false,"given":"Gennadi","family":"Tulchiner","sequence":"additional","affiliation":[{"name":"Department of Urology, Medical University Innsbruck, 6020 Innsbruck, Tyrol, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1739-5523","authenticated-orcid":false,"given":"Peter","family":"Rehder","sequence":"additional","affiliation":[{"name":"Department of Urology, Medical University Innsbruck, 6020 Innsbruck, Tyrol, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.eururo.2013.05.046","article-title":"Ventral Oral Mucosal Onlay Graft Urethroplasty in Nontraumatic Bulbar Urethral Strictures: Surgical Technique and Multivariable Analysis of Results in 214 Patients","volume":"64","author":"Barbagli","year":"2013","journal-title":"Eur. Urol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.urology.2020.08.085","article-title":"Bulbomembranous Urethral Strictures Repair After Surgical Treatment of Benign Prostatic Hyperplasia. Experience From a Latin American Referral Centre","volume":"147","author":"Favre","year":"2021","journal-title":"Urology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s11934-018-0786-z","article-title":"Reconstruction of Membranous Urethral Strictures","volume":"19","author":"Angulo","year":"2018","journal-title":"Curr. Urol. Rep."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.21037\/tau-24-430","article-title":"Endoscopic buccal urethroplasty for membranous stricture disease","volume":"14","author":"Ungerer","year":"2025","journal-title":"Transl. Androl. Urol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/j.juro.2013.10.147","article-title":"Outcomes after Urethroplasty for Radiotherapy Induced Bulbomembranous Urethral Stricture Disease","volume":"191","author":"Hofer","year":"2014","journal-title":"J. Urol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.addr.2017.05.015","article-title":"The Lutonix\u00ae drug-coated balloon: A novel drug delivery technology for the treatment of vascular disease","volume":"112","author":"Schorn","year":"2017","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1056\/NEJMoa2005206","article-title":"Mortality with Paclitaxel-Coated Devices in Peripheral Artery Disease","volume":"383","author":"Nordanstig","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_8","first-page":"968","article-title":"A Drug-Coated Balloon Treatment for Urethral Stricture Disease: Three-Year Results from the ROBUST III Study","volume":"39","author":"Srikanth","year":"2025","journal-title":"J. Endourol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Jelisejevas, L.A., Rehder, P., Wassermann, J., Kink, P., and Tulchiner, G. (2025). Optilume Drug-Coated Balloon for Acute Urinary Retention After Failed Treatment for Complex Recurrent Urethral Stricture Disease. Medicina, 61.","DOI":"10.20944\/preprints202503.1327.v1"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Kapriniotis, K., Loufopoulos, I., Apostolopoulou, A., Anderson, P.C.B., and Papaefstathiou, E. (2025). Drug-Coated Balloon Treatment for Urethral Strictures: Is This the Future? A Review of the Current Literature. J. Clin. Med., 14.","DOI":"10.3390\/jcm14082854"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Oszczud\u0142owski, M., Bia\u0142ek, \u0141., and Vetterlein, M.W. (2025). Paclitaxel-coated Balloon Dilation for Urethral Stricture Disease: 5 Years of Clinical Insights and Future Directions for Optilume. Eur. Urol. Focus, Epub ahead of print.","DOI":"10.1016\/j.euf.2025.03.013"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/S0090-4295(98)00620-7","article-title":"Iatrogenic prostatic urethral strictures: Classification and endoscopic treatment","volume":"53","author":"Pansadoro","year":"1999","journal-title":"Urology"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1159\/000515612","article-title":"Safety and Efficacy of Trans-Perineal Urethroplasty for Management of Post-Traumatic Urethral Strictures in Pediatric Age-Group","volume":"105","author":"Chaudhari","year":"2021","journal-title":"Urol. Int."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s00345-018-2498-x","article-title":"Management of post TURP strictures","volume":"37","author":"Kulkarni","year":"2019","journal-title":"World J. Urol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1097\/JU.0000000000003848","article-title":"Multi-Institutional Outcomes of Dorsal Onlay Buccal Mucosal Graft Urethroplasty in Patients With Postprostatectomy, Postradiation Anastomotic Stenosis","volume":"211","author":"Sterling","year":"2024","journal-title":"J. Urol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1097\/JU.0000000000003488","article-title":"Vesicourethral Anastomotic Stenosis Following Radical Prostatectomy: Risk Factors, Natural History, and Treatment Outcomes","volume":"210","author":"Britton","year":"2023","journal-title":"J. Urol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.21037\/tau-24-503","article-title":"A review of management options for vesicourethral anastomotic stenosis and the emergence of robotic reconstruction","volume":"14","author":"Lee","year":"2025","journal-title":"Transl. Androl. Urol."},{"key":"ref_18","first-page":"e94","article-title":"IP01-36 A Multi-Institutional Experience of Robotic Reconstruction of Vesicourethral Anastomotic Stenosis","volume":"213","author":"Elbakry","year":"2025","journal-title":"J. Urol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1007\/s00345-018-2481-6","article-title":"Treatments of 1242 bulbar urethral strictures: Multivariable statistical analysis of results","volume":"37","author":"Barbagli","year":"2019","journal-title":"World J. Urol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1097\/JU.0000000000003826","article-title":"Affirming Long-Term Outcomes After Contemporary Urethroplasty: The Adverse Impact of Increasing Stricture Length, Lichen Sclerosus, Radiation, and Infectious Strictures","volume":"211","author":"Calvo","year":"2024","journal-title":"J. Urol."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Bonanni, M., Rehak, L., Massaro, G., Benedetto, D., Matteucci, A., Russo, G., Esperto, F., Federici, M., Mauriello, A., and Sangiorgi, G.M. (2022). Autologous Immune Cell-Based Regenerative Therapies to Treat Vasculogenic Erectile Dysfunction: Is the Immuno-Centric Revolution Ready for the Prime Time?. Biomedicines, 10.","DOI":"10.3390\/biomedicines10051091"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/23\/8369\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T05:21:59Z","timestamp":1764220919000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/23\/8369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,25]]},"references-count":21,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["jcm14238369"],"URL":"https:\/\/doi.org\/10.3390\/jcm14238369","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,25]]}}}