{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T14:10:23Z","timestamp":1764166223198,"version":"3.46.0"},"reference-count":33,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Objective: To compare the effects of intravenous (IV) ferric carboxymaltose (FCM), IV ferric derisomaltose (FDI), and oral ferrous sulfate on hypophosphatemia in women with postpartum anemia. Methods: Single-centre, open-label, randomized trial. Women were randomly allocated to receive IV FCM, IV FDI, or oral ferrous sulfate. IV iron was infused in one or two doses (on days 0 and 7 postpartum), while ferrous sulfate once daily. Serum phosphate level was measured at enrollment and 6 weeks postpartum. Serum phosphate level and the proportion of women with hypophosphatemia were analyzed. The Kruskal\u2013Wallis test was used for comparison of phosphate levels and the Chi-squared test for comparison of proportions (p &lt; 0.05). Results: Three-hundred women with postpartum anemia (Hb &lt; 100 g\/L within 48 h postpartum) were included. Phosphate levels at six weeks postpartum did not differ between groups: 1.24 mmol\/L (inter-quartile range (IQR) 1.10\u20131.35; equivalent to 3.84 mg\/dL, IQR 3.41\u20134.19) in the FCM group, 1.23 mmol\/L (IQR 1.09\u20131.35; equivalent to 3.81 mg\/dL, IQR 3.38\u20134.19) in the FDI group, and 1.25 mmol\/L (IQR 1.15\u20131.34; equivalent to 3.88 mg\/dL, IQR 3.57\u20134.15) in the ferrous sulfate group (p = 0.86). The proportion of women with hypophosphatemia was similarly low in all three groups (3 (3.1%) vs. 2 (2.2%) vs. 2 (2.2%); p = 0.89). At six weeks postpartum, hemoglobin levels were slightly higher in both IV iron groups compared with oral iron, but the differences were small and unlikely to be clinically meaningful. Conclusions: Treatment of postpartum anemia with IV FCM, IV FDI, and oral ferrous sulfate had similar impact on phosphate levels and incidence of hypophosphatemia at six weeks postpartum.<\/jats:p>","DOI":"10.3390\/jcm14238393","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T13:56:34Z","timestamp":1764165394000},"page":"8393","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Risk of Hypophosphatemia Following Postpartum Anemia Treatment with IV Ferric Carboxymaltose, IV Ferric Derisomaltose, and Oral Ferrous Sulfate"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5173-1750","authenticated-orcid":false,"given":"Lea Bomba\u010d","family":"Tav\u010dar","sequence":"first","affiliation":[{"name":"Department of Perinatology, Division of Gynecology and Obstetrics, University Medical Centre Ljubljana, \u0160lajmerjeva 3, 1000 Ljubljana, Slovenia"},{"name":"Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miha","family":"Lu\u010dovnik","sequence":"additional","affiliation":[{"name":"Department of Perinatology, Division of Gynecology and Obstetrics, University Medical Centre Ljubljana, \u0160lajmerjeva 3, 1000 Ljubljana, Slovenia"},{"name":"Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hana","family":"Hrobat","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lea","family":"Gornik","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9933-549X","authenticated-orcid":false,"given":"Irena","family":"Prelo\u017enik Zupan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia"},{"name":"Department of Hematology, University Medical Centre Ljubljana, Zalo\u0161ka 7, 1000 Ljubljana, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1007\/s00277-011-1279-z","article-title":"Postpartum anemia I: Definition, prevalence, causes, and consequences","volume":"90","author":"Milman","year":"2011","journal-title":"Ann. 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