{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T02:53:15Z","timestamp":1773715995340,"version":"3.50.1"},"reference-count":25,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Objectives: The aim of this retrospective cross-sectional study was to compare maxillary sinus volume, the number of surgical interventions, and craniofacial development in patients with unilateral cleft lip and palate (UCLP). The study also sought to clarify the surgical effect on craniofacial growth. Materials and Methods: The study examined 30 patients. Computed tomography scans and lateral cephalograms were collected. The volumes of the right and left maxillary sinuses were measured using ITK-SNAP software version 4.2.2 with a semiautomatic segmentation method. Cephalometric analysis was performed, and the number of primary and secondary interventions was noted. Data were statistically analyzed, with the significance set at p &lt; 0.05. Results: Statistical analysis revealed no significant association (p &gt; 0.05) between the number of primary or secondary surgical procedures and their influence on maxillary sinus volume. A significant relationship was observed between the number of primary surgeries and the ANB angle (p = 0.034) and SNB angle (p = 0.005). Statistical significance was also found between the number of secondary surgeries and the SNA angle (p = 0.03) and ANB angle (p = 0.03). Conclusions: The results show that the number of primary and secondary surgeries does not affect maxillary sinus volume in growing UCLP patients. However, the number of primary surgeries may have some influence on subsequent profile development. The number of secondary surgeries appears to influence maxilla growth and, consequently, the maxilla\u2013mandible relationship (ANB and WITS appraisal).<\/jats:p>","DOI":"10.3390\/jcm14238468","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T15:30:07Z","timestamp":1765207807000},"page":"8468","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Assessment of the Connection Between Maxillary Sinus Volume, Number of Surgical Interventions, and Craniofacial Development in Patients with Unilateral Cleft Lip and Palate: A Retrospective Cross-Sectional Study"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1696-8562","authenticated-orcid":false,"given":"Aleksandra","family":"Ko\u0142odziejska","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry, Faculty of Medicine, Medical University of Gda\u0144sk, 80-210 Gda\u0144sk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8448-0800","authenticated-orcid":false,"given":"Wojciech","family":"Nazar","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental and Translational Allergology, Department of Allergology, Faculty of Medicine, Medical University of Gda\u0144sk, Poland, Smoluchowskiego 17, 80-214 Gda\u0144sk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7761-7728","authenticated-orcid":false,"given":"Jolanta","family":"Kalinowska","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry, Faculty of Medicine, Medical University of Gda\u0144sk, 80-210 Gda\u0144sk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3709-3576","authenticated-orcid":false,"given":"Bogna","family":"Racka-Pilszak","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry, Faculty of Medicine, Medical University of Gda\u0144sk, 80-210 Gda\u0144sk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2718-2903","authenticated-orcid":false,"given":"Anna","family":"Wojtaszek-S\u0142omi\u0144ska","sequence":"additional","affiliation":[{"name":"Medical University of Gda\u0144sk, 80-210 Gda\u0144sk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,28]]},"reference":[{"key":"ref_1","unstructured":"(2025, September 23). European Platform on Rare Disease Registration. Available online: https:\/\/eu-rd-platform.jrc.ec.europa.eu."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/S0140-6736(09)60695-4","article-title":"Cleft lip and palate","volume":"374","author":"Mossey","year":"2009","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1288\/00005537-199109000-00011","article-title":"The embryonic development of the lateral nasal wall from 8 to 24 weeks","volume":"101","author":"Bingham","year":"1991","journal-title":"Laryngoscope"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1002\/ar.20774","article-title":"The development and pathologic processes that influence maxillary sinus pneumatization","volume":"291","author":"Lawson","year":"2008","journal-title":"Anat. Rec."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"20190205","DOI":"10.1259\/dmfr.20190205","article-title":"The maxillary sinus: Physiology, development and imaging anatomy","volume":"48","author":"Whyte","year":"2019","journal-title":"Dentomaxillofac. Radiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/lary.1982.92.2.183","article-title":"Maxillary sinus development in patients with cleft palates as compared to those with normal palates","volume":"92","author":"Robinson","year":"1982","journal-title":"Laryngoscope"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0385-8146(99)00066-8","article-title":"Maxillary sinus development and sinusitis in patients with cleft lip and palate","volume":"27","author":"Suzuki","year":"2000","journal-title":"Auris Nasus Larynx"},{"key":"ref_8","unstructured":"(2025, October 13). Standards of Care. ERN CRANIO Website. Available online: https:\/\/www.ern-cranio.eu\/standards-of-care."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1097\/SCS.0000000000008296","article-title":"Midface Growth Potential in Unoperated Clefts: A Systematic Review and Meta-Analysis","volume":"33","author":"Wlodarczyk","year":"2022","journal-title":"J. Craniofacial Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1177\/10556656221116005","article-title":"Sagittal Growth Restriction of the Midface Following Isolated Cleft Lip Repair: A Systematic Review and Meta-Analysis","volume":"61","author":"Celie","year":"2024","journal-title":"Cleft Palate Craniofacial J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1597\/1545-1569_1992_029_0112_csmboc_2.3.co_2","article-title":"Craniofacial skeletal measurements based on computed tomography: Part I. Accuracy and reproducibility","volume":"29","author":"Waitzman","year":"1992","journal-title":"Cleft Palate Craniofacial J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1093\/dmfr\/twaf042","article-title":"Comparisons of AI automated segmentation techniques to manual segmentation techniques of the maxilla and maxillary sinus for CT or CBCT scans-A Systematic review","volume":"54","author":"Park","year":"2025","journal-title":"Dentomaxillofacial Radiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1177\/10556656221080359","article-title":"Cone-Beam Computed Tomographic Assessment of Maxillary Sinus Characteristics in Patients with Cleft Lip and Palate: A Systematic Review and Meta-Analysis","volume":"60","author":"Srivastav","year":"2023","journal-title":"Cleft Palate Craniofacial J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1016\/j.ijporl.2014.10.019","article-title":"Difference in maxillary sinus volumes of patients with cleft lip and palate","volume":"78","author":"Pimenta","year":"2014","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.1016\/j.ajodo.2020.08.011","article-title":"A retrospective and tridimensional study of the maxillary sinus in patients with cleft lip and palate","volume":"159","author":"Rodrigues","year":"2021","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.4103\/sja.SJA_543_18","article-title":"The STROBE guidelines","volume":"13","author":"Cuschieri","year":"2019","journal-title":"Saudi J. Anaesth."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1177\/1055665617726991","article-title":"Does Unilateral Cleft Lip and Palate Affect the Maxillary Sinus Volume?","volume":"55","author":"Demirtas","year":"2018","journal-title":"Cleft Palate Craniofacial J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e23","DOI":"10.1097\/SCS.0b013e318267bdf3","article-title":"Evaluation of maxillary sinus volume in cleft alveolus patients using 3-dimensional computed tomography","volume":"24","author":"Hikosaka","year":"2013","journal-title":"J. Craniofacial Surg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s11282-020-00506-2","article-title":"Evaluation of maxillary sinus volume in different craniofacial patterns: A CBCT study","volume":"37","author":"Shrestha","year":"2021","journal-title":"Oral Radiol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Din\u00e7, K., and \u0130\u00e7\u00f6z, D. (2024). Maxillary sinus volume changes in individuals with different craniofacial skeletal patterns: CBCT study. BMC Oral Health, 24.","DOI":"10.1186\/s12903-024-05341-z"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"200","DOI":"10.5603\/fm.100054","article-title":"Relation between orthodontic malocclusion and maxillary sinus volume","volume":"84","author":"Akkurt","year":"2025","journal-title":"Folia Morphol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e517","DOI":"10.1097\/SCS.0000000000002028","article-title":"Characteristics of Maxillary Morphology in Unilateral Cleft Lip and Palate Patients Compared to Normal Subjects and Skeletal Class III Patients","volume":"26","author":"Jiang","year":"2015","journal-title":"J. Craniofacial Surg."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.ajodo.2016.03.031","article-title":"Cone-beam computed tomography-synthesized cephalometric study of operated unilateral cleft lip and palate and noncleft children with Class III skeletal relationship","volume":"150","author":"Lin","year":"2016","journal-title":"Am. J. Orthod. Dentofac. Orthop."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1097\/SCS.0000000000009191","article-title":"Influence of Lip Revision Surgery on Facial Growth in Patients with A Cleft Lip","volume":"34","author":"Kamata","year":"2023","journal-title":"J. Craniofacial Surg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1177\/10556656231188600","article-title":"Effects of Secondary Alveolar Bone Grafting on Maxillary Growth in Cleft Lip or Palate Patients: A Systematic Review and Meta-Analysis","volume":"61","author":"Kannan","year":"2024","journal-title":"Cleft Palate Craniofacial J."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/23\/8468\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T15:49:07Z","timestamp":1765208947000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/23\/8468"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,28]]},"references-count":25,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["jcm14238468"],"URL":"https:\/\/doi.org\/10.3390\/jcm14238468","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,28]]}}}