{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T16:04:03Z","timestamp":1765209843169,"version":"3.46.0"},"reference-count":69,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Occupational dermatoses represent a significant challenge across numerous industries. Therefore, occupational skin protection creams are frequently used as a preventative measure, yet their efficacy, particularly against hydrophobic working materials, remains inconclusive. This review provides an overview of the current knowledge concerning the mechanisms by which skin protection creams support skin barrier function, as well as the limitations of available testing methods. Current evaluation methods range from in vitro assays to ex vivo and in vivo models, each possessing distinct advantages and disadvantages. While several clinical studies demonstrate effectiveness against hydrophilic irritants, standardized and ethically viable methods for assessing protection against hydrophobic substances are lacking. Future research should focus on the development and validation of improved in vitro and ex vivo models, coupled with enhanced workplace simulation techniques, to facilitate a more accurate translation of laboratory findings to real-world occupational settings. Consistent and reliable testing is essential to ensure continued efficacy of these products in light of evolving regulatory landscapes.<\/jats:p>","DOI":"10.3390\/jcm14238470","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T15:30:07Z","timestamp":1765207807000},"page":"8470","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["From Lab to Workplace: Efficacy of Skin Protection Creams Against Hydrophobic Working Materials"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5525-9245","authenticated-orcid":false,"given":"Anja","family":"Dick","sequence":"first","affiliation":[{"name":"Peter Greven Physioderm GmbH, 53881 Euskirchen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2203-2049","authenticated-orcid":false,"given":"Magdalena","family":"Metzger","sequence":"additional","affiliation":[{"name":"Ludwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA, 1200 Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6302-530X","authenticated-orcid":false,"given":"Peter","family":"Dungel","sequence":"additional","affiliation":[{"name":"Ludwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA, 1200 Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s12016-018-8713-0","article-title":"Irritant Contact Dermatitis","volume":"56","author":"Bains","year":"2019","journal-title":"Clin. 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