{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:29:00Z","timestamp":1790108940631,"version":"4.0.1"},"reference-count":15,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Purpose: Reconstructive options for mucosal defects of the oral cavity resulting from the resection of tumors include primary closure, mucosal and split thickness skin grafts, pedicle flaps, and microvascular free flaps. Lately the use of an acellular dermal bilayer matrix has been introduced for the reconstruction of superficial mucosal defects of the oral cavity. Methods: Twenty-one patients treated for SCC of the oral cavity with intraoral resection and simultaneous reconstruction using a bilayer dermal matrix between 1 January 2020 and 31 December 2024 with at least 6 months of follow-up were retrospectively considered. Data were collected regarding the site of the lesion, the initial TNM staging, the size of the surgical defect, the timing of silicone sheet removal, the complications and the long-term outcomes. Results: Tumor site included the tongue in 16 cases, the hard palate in 1 case, the cheek in 2 cases, the floor of the mouth in 1 patient, and the inferior lip in 1 patient. Re-epithelialization was achieved in all cases within 21 days. No major complication was observed. Conclusions: Bilayer dermal matrix demonstrated to be an excellent option for small and superficial oral cavity reconstruction if proper indications are followed.<\/jats:p>","DOI":"10.3390\/jcm14238534","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T16:20:29Z","timestamp":1765210829000},"page":"8534","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Reconstruction of Surgical Defects of the Oral Cavity with Bilayer Dermal Matrix: Our Experience"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2297-1150","authenticated-orcid":false,"given":"Andrea","family":"Ferri","sequence":"first","affiliation":[{"name":"Department of Maxillofacial Surgery, University Hospital of Parma, 43126 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"David","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Surgery, University Hospital of Parma, 43126 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Salti","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Surgery, University Hospital of Parma, 43126 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4265-097X","authenticated-orcid":false,"given":"Giovanni","family":"Lilloni","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Surgery, University Hospital of Parma, 43126 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2184-3931","authenticated-orcid":false,"given":"Bernardo","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Surgery, San Martino Hospital, 16132 Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvano","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Surgery, University Hospital of Parma, 43126 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.oraloncology.2008.06.002","article-title":"Global epidemiology of oral and oropharyngeal cancer","volume":"45","author":"Warnakulasuriya","year":"2009","journal-title":"Oral Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1002\/lary.20548","article-title":"Acellular dermis compared to skin graft in oral cavity reconstruction","volume":"119","author":"Girod","year":"2009","journal-title":"Laryngoscope"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/ccr3.3501","article-title":"Reconstruction of intraoral oncologic surgical defects with Integra\u00aebilayer wound matrix","volume":"9","author":"Srivastava","year":"2020","journal-title":"Clin. Case Rep."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1097\/00006534-200107000-00015","article-title":"Reconstructive surgery with a dermal regeneration template: Clinical and histologic study","volume":"108","author":"Moiemen","year":"2001","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_5","first-page":"1201","article-title":"The use of processed allograft dermal matrix for intraoral resurfacing","volume":"124","author":"Rhee","year":"1998","journal-title":"JAMA Otolaryngol.-Head Neck Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.bjoms.2017.12.017","article-title":"Long-term quality of life measured by the University. Washington QoL questionnaire (version 4) in patients with oral cancer treated with or without reconstruction with a microvascular free flap","volume":"56","author":"Yue","year":"2018","journal-title":"Br. J. Oral Maxillofac. Surg."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1001\/jamaoto.2023.4049","article-title":"Oral Cavity Cancer Surgical and Nodal Management: A Review From the American Head and Neck Society","volume":"150","author":"Eskander","year":"2024","journal-title":"JAMA Otolaryngol.-Head Neck Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"E1200","DOI":"10.1002\/hed.24191","article-title":"Oncologic safety of facial artery myomucosal flaps in oral cavity reconstruction","volume":"38","author":"Ferrari","year":"2016","journal-title":"Head Neck"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.joms.2006.10.036","article-title":"Buccinator myomucosal island flap for reconstruction of the floor of the mouth","volume":"66","author":"Ferrari","year":"2008","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.tripleo.2010.05.051","article-title":"Donor site morbidity using the buccinator myomucosal island flap","volume":"111","author":"Ferrari","year":"2011","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1051\/mbcb\/2020050","article-title":"Rapid prototyping: Applications in oral and maxillofacial surgery","volume":"27","author":"Giovacchini","year":"2020","journal-title":"J. Oral. Med. Oral. Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"101911","DOI":"10.1016\/j.jormas.2024.101911","article-title":"Reconstruction of oral mucosal defects with regenerative dermal matrix after T1-T2 squamocellular carcinoma resection","volume":"125","author":"Consorti","year":"2024","journal-title":"J. Stomatol. Oral Maxillofac. Surg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s12663-023-01889-5","article-title":"Dermal Regeneration Template: Reconstruction in Oral Cancer Defects","volume":"22","author":"Mangini","year":"2023","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1097\/00020840-200308000-00001","article-title":"Hard and Soft palate reconstruction","volume":"11","year":"2003","journal-title":"Curr. Opin. Otolaryngol. Head Neck Surg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1097\/MOO.0b013e32833a6d7f","article-title":"Reconstruction of cheek defects: A review of current techniques","volume":"18","author":"Jowett","year":"2010","journal-title":"Curr. Opin. Otolaryngol. 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