{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T12:27:48Z","timestamp":1793881668481,"version":"4.7.0"},"reference-count":67,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Kirk Kerkorian School of Medicine at the University of Nevada"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Chronic cutaneous wounds such as diabetic foot ulcers, venous leg ulcers, pressure injuries, and burns remain a global clinical burden. These wounds are often arrested in inflammatory or ischemic stages due to impaired angiogenesis and growth factor deficiencies. Biologic therapies, such as platelet-rich plasma (PRP) and recombinant growth factors, aim to restore these deficits and accelerate repair. Methods: A narrative review of PubMed and Google Scholar (2015\u20132025) identified 64 English-language studies, including randomized controlled trials, meta-analyses, and translational investigations evaluating PRP and recombinant growth factors in wound healing. Results: Randomized trials and meta-analyses show that adjunctive autologous PRP increases complete wound closure versus standard care in chronic ulcers, including diabetic foot and venous leg ulcers (odds ratios \u2248 2\u20138), and improves healing rates in pressure injuries (odds ratio \u2248 3.4), without increasing adverse events. In diabetic foot ulcers, PDGF-BB and EGF, together with PRP, consistently improve complete healing and reduce ulcer area. In burns, topical EGF and bFGF shorten healing time by ~3 days in superficial partial-thickness wounds and by &gt;5 days in deeper burns, with generally improved scar outcomes. Conclusions: PRP offers broad, autologous biologic activation, while recombinant growth factors deliver high-potency, targeted precision. Together, they represent complementary regenerative strategies that can shorten healing times and improve outcomes in chronic wounds. Standardized multicenter trials quantifying cytokine composition, cost-effectiveness, and long-term limb-salvage benefit are warranted to guide their integration into routine clinical practice.<\/jats:p>","DOI":"10.3390\/jcm14238583","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T16:20:29Z","timestamp":1765210829000},"page":"8583","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Platelet-Rich Plasma (PRP) and Recombinant Growth Factor Therapies in Cutaneous Wound Healing: Mechanisms, Clinical Applications, and Future Directions"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0844-9357","authenticated-orcid":false,"given":"Abu-Bakr","family":"Ahmed","sequence":"first","affiliation":[{"name":"Kirk Kerkorian School of Medicine, University of Nevada, Las Vegas, Las Vegas, NV 89106, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spencer","family":"Thatcher","sequence":"additional","affiliation":[{"name":"Kirk Kerkorian School of Medicine, University of Nevada, Las Vegas, Las Vegas, NV 89106, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6426-5915","authenticated-orcid":false,"given":"Joshua","family":"Khorsandi","sequence":"additional","affiliation":[{"name":"Kirk Kerkorian School of Medicine, University of Nevada, Las Vegas, Las Vegas, NV 89106, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Lake Erie College of Osteopathic Medicine, Elmira, NY 14901, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4737-4231","authenticated-orcid":false,"given":"Michael","family":"Lee","sequence":"additional","affiliation":[{"name":"Kirk Kerkorian School of Medicine, University of Nevada, Las Vegas, Las Vegas, NV 89106, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1350-3886","authenticated-orcid":false,"given":"Adam","family":"Jaouhari","sequence":"additional","affiliation":[{"name":"School of Integrated Health Sciences, University of Nevada, Las Vegas, Las Vegas, NV 89106, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Braydon","family":"Bond","sequence":"additional","affiliation":[{"name":"School of Integrated Health Sciences, University of Nevada, Las Vegas, Las Vegas, NV 89106, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0969-2539","authenticated-orcid":false,"given":"Aftab","family":"Merchant","sequence":"additional","affiliation":[{"name":"Kirk Kerkorian School of Medicine, University of Nevada, Las Vegas, Las Vegas, NV 89106, USA"},{"name":"Department of Medical Education, Kirk Kerkorian School of Medicine, University of Nevada, Las Vegas, Las Vegas, NV 89106, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s10916-025-02153-8","article-title":"Artificial Intelligence Methods for Diagnostic and Decision-Making Assistance in Chronic Wounds: A Systematic Review","volume":"49","year":"2025","journal-title":"J. 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