{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T10:05:10Z","timestamp":1787133910720,"version":"build-2736575974"},"reference-count":157,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative condition characterized by the degeneration of upper and lower motor neurons. This degeneration leads to a gradual muscle weakness, dysarthria, dysphagia, respiratory insufficiency, and, in some patients, alterations in cognitive and behavioral performance. Regardless of advancements made in pharmacological and gene-targeted interventions, a definitive curative treatment remains elusive. Consequently, rehabilitation plays a pivotal role in preserving autonomy, participation, and overall quality of life. This review outlines the current evidence and clinical approaches related to multidisciplinary rehabilitation in ALS. It covers physical and occupational therapy, respiratory, speech and language, psychological, and palliative care domains. Evidence supports moderate tailored exercise programs, early respiratory therapy, and structured management of mobility deficits, spasticity, pain, dysphagia, and communication impairments as key elements of symptomatic treatment. Psychological and social support, which includes the involvement of caregivers and relatives, enhances emotional well-being and coping resilience. Even with progressive development of gene-targeted and disease-modifying therapies, rehabilitation will stay relevant for maintaining long-term motor function. This review highlights the need for standardized, evidence-based rehabilitation protocols and intensified neurorehabilitation research to strengthen clinical outcomes and quality of life as key therapeutic goals in ALS management.<\/jats:p>","DOI":"10.3390\/jcm14238590","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T16:20:29Z","timestamp":1765210829000},"page":"8590","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Rehabilitation in Amyotrophic Lateral Sclerosis: Recommendations for Clinical Practice and Further Research"],"prefix":"10.3390","volume":"14","author":[{"given":"Andreas","family":"Gratzer","sequence":"first","affiliation":[{"name":"Department of Neurology, m&i Fachklinik-Enzensberg, 87629 F\u00fcssen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6690-7748","authenticated-orcid":false,"given":"Natalie","family":"Gdynia","sequence":"additional","affiliation":[{"name":"Department of Neurology, m&i Fachklinik-Enzensberg, 87629 F\u00fcssen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Sasse","sequence":"additional","affiliation":[{"name":"Clinic Hoher Mei\u00dfner, 37242 Bad Sooden-Allendorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Beese","sequence":"additional","affiliation":[{"name":"Clinic Hoher Mei\u00dfner, 37242 Bad Sooden-Allendorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cordula","family":"Winterholler","sequence":"additional","affiliation":[{"name":"Network Dysphagia, Outpatient Center for Swallowing Disorders, 90431 Nuernberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Bauer","sequence":"additional","affiliation":[{"name":"Clinic Hoher Mei\u00dfner, 37242 Bad Sooden-Allendorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Schr\u00f6ter","sequence":"additional","affiliation":[{"name":"German Society for Muscle Diseases (DGM), 97112 Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0743-9670","authenticated-orcid":false,"given":"Hans-J\u00fcrgen","family":"Gdynia","sequence":"additional","affiliation":[{"name":"Department of Neurology, m&i Fachklinik-Enzensberg, 87629 F\u00fcssen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1111\/j.1468-1331.2011.03501.x","article-title":"EFNS Guidelines on the Clinical Management of Amyotrophic Lateral Sclerosis (MALS)\u2014Revised Report of an EFNS Task Force","volume":"19","author":"Andersen","year":"2012","journal-title":"Eur. 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