{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T06:14:04Z","timestamp":1765260844990,"version":"3.46.0"},"reference-count":44,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medical University of Silesia in Katowice","award":["BNW-1-043\/K\/5\/K","BNW-1-023\/N\/3\/K"],"award-info":[{"award-number":["BNW-1-043\/K\/5\/K","BNW-1-023\/N\/3\/K"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Acne vulgaris is a common inflammatory disorder with significant clinical and psychosocial impacts. Medium-depth chemical peels are increasingly used to manage both active acne lesions and atrophic acne scars. This study aimed to quantitatively assess the clinical effectiveness of a novel multimodal medium-depth chemical peel regimen, yellow peel, in improving acne severity and scar depth, as well as skin hydration and sebum production in patients with mild to moderate facial acne. Methods: Twenty patients (17 women and 3 men) aged 20\u201325 with mild to moderate acne vulgaris underwent two sessions of yellow peel treatment at four-week intervals. The peel protocol combined glycolic acid, salicylic acid, and a multi-acid mask containing retinol, azelaic, phytic, kojic, and salicylic acids. Clinical outcomes were evaluated at baseline, four weeks after the first peel, and two months after the second peel. Assessments included the Investigators Global Assessment (IGA), inflammatory lesion count, 3D scar depth analysis, skin hydration (corneometer), and sebum secretion (sebumeter). Results: Yellow peel treatment significantly reduced acne severity, with an 85% decrease in inflammatory lesion counts and over 20% reduction in scar depth. Skin hydration improved significantly across all facial regions, and sebum secretion decreased substantially, enhancing skin barrier function and seboregulation. Statistical analysis confirmed the treatment\u2019s efficacy with sustained improvements two months post-final peel. Conclusions: The yellow peel protocol is an effective and well-tolerated adjunct therapy for managing mild to moderate acne and atrophic acne scars. By combining exfoliative, anti-inflammatory, antibacterial, sebostatic, and depigmenting agents, this multimodal approach delivers comprehensive skin improvement. Further large-scale, controlled studies are recommended to confirm long-term safety and efficacy.<\/jats:p>","DOI":"10.3390\/jcm14238598","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T16:20:29Z","timestamp":1765210829000},"page":"8598","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cosmetic Benefits of Medium-Depth Chemical Peels for Moderate Acne Lesions and Atrophic Acne Scars: A Single-Arm Clinical Trial in Young Adults"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1763-6676","authenticated-orcid":false,"given":"Anna","family":"Deda","sequence":"first","affiliation":[{"name":"Department of Practical Cosmetology and Skin Diagnostics, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, ul. Jedno\u015bci 8, 41-200 Sosnowiec, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3986-3295","authenticated-orcid":false,"given":"Magdalena","family":"Hartman-Petrycka","sequence":"additional","affiliation":[{"name":"Department of Basic Biomedical Sciences, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, ul. Jedno\u015bci 8B, 41-200 Sosnowiec, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"G\u0119do\u015b","sequence":"additional","affiliation":[{"name":"Student Scientific Society, Department of Practical Cosmetology and Skin Diagnostics, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, ul. Jedno\u015bci 8, 41-200 Sosnowiec, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martyna","family":"Wojciechowska","sequence":"additional","affiliation":[{"name":"Student Scientific Society, Department of Practical Cosmetology and Skin Diagnostics, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, ul. Jedno\u015bci 8, 41-200 Sosnowiec, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0501-7592","authenticated-orcid":false,"given":"Dominika","family":"Wcis\u0142o-Dziadecka","sequence":"additional","affiliation":[{"name":"Department of Practical Cosmetology and Skin Diagnostics, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, ul. Jedno\u015bci 8, 41-200 Sosnowiec, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"298","DOI":"10.4103\/0378-6323.199581","article-title":"Update on etiopathogenesis and treatment of Acne","volume":"83","author":"Bhat","year":"2017","journal-title":"Indian J. Dermatol. Venereol. Leprol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s00403-019-01908-x","article-title":"From pathogenesis of acne vulgaris to anti-acne agents","volume":"311","author":"Cong","year":"2019","journal-title":"Arch. Dermatol. Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"403","DOI":"10.4103\/0019-5154.185703","article-title":"Etiopathogenesis and Therapeutic Approach to Adult Onset Acne","volume":"61","author":"Kaur","year":"2016","journal-title":"Indian J. 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