{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T16:22:05Z","timestamp":1765383725457,"version":"3.46.0"},"reference-count":35,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: For many patients with malignant spinal cord compression (MSCC) not suitable for surgery, irradiation alone is the preferred treatment. A dose-fractionation regimen of 10 \u00d7 3 Gy is common for this situation. Since most patients suffer from motor deficits and pain, the number of radiotherapy sessions should be as low as possible. A secondary analysis of a phase 2 trial compared 5 \u00d7 5 Gy to a historical control group treated with 10 \u00d7 3 Gy. After 1:2 matching, 5\u2009 \u00d7 \u20095 Gy appeared similarly effective regarding local progression-free survival (LPFS) at 6 months, motor function, walking ability, and overall survival. Methods: This retrospective study investigated whether these findings are consistent in a larger cohort and after longer follow-up. Additional data were gathered for the phase 2 cohort, follow-up in the control group was not limited to 6 months, and the number of patients in the control group increased from 213 to 728. Results: After propensity-score matching, no significant differences were found regarding LPFS after 12 (p = 0.198), 18 (p = 0.139), and 24 (p = 0.117) months, effect on motor function (p = 0.393), walking ability (p = 0.079), 24-month local control (p = 0.655), and 24-month OS (p = 0.403). Conclusions: Given the limitations of this study, 5 \u00d7 5 Gy appears preferable to 10 \u00d7 3 Gy in selected patients receiving irradiation without upfront surgery. Clinicians should balance initial convenience for the patients and future limitations when re-irradiation in the same part of the spine is required.<\/jats:p>","DOI":"10.3390\/jcm14248741","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T16:11:18Z","timestamp":1765383078000},"page":"8741","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long-Term Results of a Propensity Score Analysis Comparing 5 \u00d7 5 Gy and 10 \u00d7 3 Gy of Radiotherapy Alone for Malignant Spinal Cord Compression"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2046-4968","authenticated-orcid":false,"given":"Dirk","family":"Rades","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, University Medical Center Schleswig-Holstein, L\u00fcbeck Campus, 23538 L\u00fcbeck, Germany"},{"name":"Department of Radiation Oncology, University of L\u00fcbeck, 23562 L\u00fcbeck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darejan","family":"Lomidze","sequence":"additional","affiliation":[{"name":"Radiation Oncology Department, Tbilisi State Medical University, Tbilisi 0177, Georgia"},{"name":"Radiation Oncology Department, Ingorokva High Medical Technology University Clinic, Tbilisi 0177, Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9122-7646","authenticated-orcid":false,"given":"Carlos","family":"Ferrer-Albiach","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Consorcio Hospital Provincial de Castellon, 12002 Castellon, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1024-0924","authenticated-orcid":false,"given":"Antonio Jose","family":"Conde-Moreno","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Consorcio Hospital Provincial de Castellon, 12002 Castellon, Spain"},{"name":"Department of Radiation Oncology, University and Polytechnic Hospital La Fe, 46026 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0309-6282","authenticated-orcid":false,"given":"Barbara","family":"Segedin","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, Institute of Oncology Ljubljana, 1000 Ljubljana, Slovenia"},{"name":"Department of Radiotherapy, Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4799-2978","authenticated-orcid":false,"given":"Blaz","family":"Groselj","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, Institute of Oncology Ljubljana, 1000 Ljubljana, Slovenia"},{"name":"Department of Radiotherapy, Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0130-878X","authenticated-orcid":false,"given":"Raquel","family":"Ci\u00e9rvide Jurio","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University Hospital HM Sanchinarro, 28050 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4077-0507","authenticated-orcid":false,"given":"Fernando","family":"L\u00f3pez Campos","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University Hospital Ram\u00f3n y Cajal, 28034 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8073-5781","authenticated-orcid":false,"given":"Charlotte","family":"Kristiansen","sequence":"additional","affiliation":[{"name":"Department of Oncology, Vejle Hospital, University Hospital of Southern Denmark, 7100 Vejle, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristopher","family":"Dennis","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, The Ottawa Hospital and the University of Ottawa, Ottawa, ON K1Y 4E9, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon","family":"Cacicedo","sequence":"additional","affiliation":[{"name":"Radiation Oncology Department, Hospital Universitario Cruces, 48903 Barakaldo, Spain"},{"name":"Radiation Oncology Department, Biobizkaia Health Research Institute, 48903 Barakaldo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S1470-2045(05)70022-X","article-title":"Malignant spinal cord compression","volume":"6","author":"Prasad","year":"2005","journal-title":"Lancet 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