{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:06:19Z","timestamp":1765544779131,"version":"3.48.0"},"reference-count":30,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Kanagawa Dental University Project Research Grants","award":["2023_04"],"award-info":[{"award-number":["2023_04"]}]},{"name":"Kanagawa Dental University Project Research Grants","award":["2024_04"],"award-info":[{"award-number":["2024_04"]}]},{"name":"Kanagawa Dental University Project Research Grants","award":["2025_02"],"award-info":[{"award-number":["2025_02"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Periodontal disease may progress despite supportive periodontal therapy (SPT), and conventional clinical parameters exhibit limited predictive value. This study evaluated the prognostic utility of measuring the oral fluid lactate dehydrogenase (LD) activity using a chairside test strip to predict disease progression during SPT. Methods: A cohort of 92 patients (33 males and 59 females; median age, 68 years) undergoing SPT at a university clinic in 2023 were followed up for approximately one year. Oral fluid LD activity was measured using a test strip, and clinical periodontal parameters were assessed at baseline and follow-up. Periodontitis progression was defined as \u22654 sites showing a 2 mm increase in the probing pocket depth, which reached \u22654 mm. Receiver operating characteristic analyses and stepwise logistic regression were used to evaluate the predictive performance of oral fluid LD activity and develop a multivariate model. Results: Seventeen patients (18.5%) developed progressive periodontitis. Progressive cases demonstrated significantly higher baseline LD activity and periodontal parameters. The optimal cutoff value for LD activity was 3.5, yielding a sensitivity, specificity, and negative predictive value of 1.00, 0.53, and 1.00, respectively. Logistic regression identified oral fluid LD and medications as independent predictors, with the multivariate model achieving an area under the curve of 0.785. Conclusions: Oral fluid LD activity measured using the test strip provided prognostic information for periodontitis progression during SPT. Incorporating LD with information obtained from medical interviews did not markedly enhance the predictive accuracy. This rapid and noninvasive method may facilitate risk-based patient management and personalized supportive care.<\/jats:p>","DOI":"10.3390\/jcm14248810","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T12:52:31Z","timestamp":1765543951000},"page":"8810","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prediction of Periodontal Disease Progression During Supportive Periodontal Therapy Using an Oral Fluid Lactate Dehydrogenase Activity-Based Test Strip"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5147-3711","authenticated-orcid":false,"given":"Tatsuo","family":"Yamamoto","sequence":"first","affiliation":[{"name":"Department of Preventive Dentistry and Dental Public Health, Kanagawa Dental University, 82 Inaoka-Cho, Yokosuka 238-8580, Kanagawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satsuki","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Advanced Periodontology, Yokohama Clinic, Kanagawa Dental University, 3-31-6 Tsuruya-Cho, Yokohama 221-0835, Kanagawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohei","family":"Kamata","sequence":"additional","affiliation":[{"name":"Department of Advanced Periodontology, Yokohama Clinic, Kanagawa Dental University, 3-31-6 Tsuruya-Cho, Yokohama 221-0835, Kanagawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahisa","family":"Hirata","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Kanagawa Dental University, 82 Inaoka-Cho, Yokosuka 238-8580, Kanagawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichiro","family":"Nanashima","sequence":"additional","affiliation":[{"name":"Department of Preventive Dentistry and Dental Public Health, Kanagawa Dental University, 82 Inaoka-Cho, Yokosuka 238-8580, Kanagawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichiro","family":"Irie","sequence":"additional","affiliation":[{"name":"Department of Oral Health, Medical and Dental Sciences, Graduate School of Biomedical Sciences, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Nagasaki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4301-2426","authenticated-orcid":false,"given":"Motohiro","family":"Komaki","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Kanagawa Dental University, 82 Inaoka-Cho, Yokosuka 238-8580, Kanagawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,12]]},"reference":[{"key":"ref_1","unstructured":"GBD 2021 Oral Disorders Collaborators (2025). 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