{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:50:39Z","timestamp":1781585439711,"version":"3.54.5"},"reference-count":21,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Kidney transplantation remains the most effective treatment for patients with end-stage kidney disease, increasing both survival and quality of life. There are concerns regarding the long-term outcomes of donors in developing countries, as kidney transplants are predominantly performed from living donors. This study was conducted to evaluate the long-term clinical outcomes of living kidney donors, with a particular focus on kidney and cardiovascular health. Methods: We retrospectively reviewed the records of 232 individuals who underwent donor nephrectomy between January 2011 and November 2022. Cardiovascular events, mortality, chronic kidney disease, hypertension, and newly onset diabetes were assessed. Estimated glomerular filtration rate (eGFR) values were employed to monitor kidney function over time. Results: Living kidney donors were monitored for a median of 6 years (IQR: 4\u20139 years). During the follow-up period, 18.9% of donors experienced a decline in eGFR to below 60 mL\/min\/1.73 m2; however, none progressed to end-stage kidney disease. Of the cohort, 20 (8.6%) had newly onset proteinuria and none had proteinuria before transplantation. Although there were no recorded deaths from cardiovascular causes, 4.3% of donors experienced major adverse cardiac events. 12.3% of donors had newly diagnosed hypertension following transplantation, and 20.2% of donors had hypertension overall. Lower baseline eGFR, treated as a continuous variable in the logistic regression model, was independently associated with a higher likelihood of post-donation eGFR &lt; 60 mL\/min\/1.73 m2 (OR: 0.91; 95% CI: 0.88\u20130.94; p &lt; 0.001). Post donation proteinuria (OR: 6.61; 95% CI: 1.98\u201322.07, p: 0.002) was also identified as independent risk factors for decline in eGFR to below 60 mL\/min\/1.73 m2. Diabetes mellitus was found to be a significant predictor of newly onset hypertension. Conclusions: A considerable percentage of the donors experienced gradual deterioration in kidney function, even though none of them developed kidney failure necessitating dialysis. The prevalence of obesity and chronic kidney disease was higher post-donation compared to the general population, indicating the need for structured long-term monitoring.<\/jats:p>","DOI":"10.3390\/jcm14248908","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T08:32:27Z","timestamp":1765960347000},"page":"8908","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Long-Term Outcomes of Living Kidney Donors in a Developing Country: A Single-Center Study"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3583-7539","authenticated-orcid":false,"given":"Alparslan","family":"G\u00fcne\u015f","sequence":"first","affiliation":[{"name":"Department of Nephrology, Faculty of Medicine, Ankara University, 0600 Ankara, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7529-3010","authenticated-orcid":false,"given":"Gizem","family":"Kumru","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Faculty of Medicine, Ankara University, 0600 Ankara, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0855-6607","authenticated-orcid":false,"given":"Ebru","family":"Dumlup\u0131nar","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Faculty of Medicine, Ankara University, 0600 Ankara, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2831-2682","authenticated-orcid":false,"given":"\u015eule","family":"\u015eeng\u00fcl","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Faculty of Medicine, Ankara University, 0600 Ankara, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3250-8998","authenticated-orcid":false,"given":"Kenan","family":"Keven","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Faculty of Medicine, Ankara University, 0600 Ankara, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,17]]},"reference":[{"key":"ref_1","unstructured":"(2025, July 22). Transplantation GOoDa. GODT. Available online: https:\/\/www.transplant-observatory.org\/summary\/."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1056\/NEJMoa0804883","article-title":"Long-Term Consequences of Kidney Donation","volume":"360","author":"Ibrahim","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/ndt\/gfr669","article-title":"Outcome of the living kidney donor","volume":"27","author":"Delanaye","year":"2012","journal-title":"Nephrol. Dial. Transpl."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"sfae244","DOI":"10.1093\/ckj\/sfae244","article-title":"Hypertension in living kidney donors: Understanding the real risk","volume":"17","author":"Kumru","year":"2024","journal-title":"Clin. Kidney J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.2215\/CJN.04020419","article-title":"Self-Reported Incident Hypertension and Long-Term Kidney Function in Living Kidney Donors Compared with Healthy Nondonors","volume":"14","author":"Holscher","year":"2019","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"276","DOI":"10.7326\/M17-1235","article-title":"Mid- and Long-Term Health Risks in Living Kidney Donors: A Systematic Review and Meta-analysis","volume":"168","author":"Ramond","year":"2018","journal-title":"Ann. Intern. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1681\/ASN.2016020154","article-title":"The Substantial Loss of Nephrons in Healthy Human Kidneys with Aging","volume":"28","author":"Denic","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Oruc, A., Pekin, D., Kahraman, C.S., Ortac, H., Gullulu, E., Gul, C.B., Y\u0131ld\u0131z, A., Ersoy, A., Yavuz, M., and Gullulu, M. (2025). Evaluation of Risk Factors for Kidney Function Decline and Chronic Kidney Disease in Living Kidney Donors. J. Clin. Med., 14.","DOI":"10.3390\/jcm14113873"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1093\/ndt\/gfq656","article-title":"A population-based survey of Chronic REnal Disease in Turkey--the CREDIT study","volume":"26","author":"Arinsoy","year":"2011","journal-title":"Nephrol. Dial. Transpl."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/ki.2013.460","article-title":"Long-term risks for kidney donors","volume":"86","author":"Hallan","year":"2014","journal-title":"Kidney Int."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1001\/jama.2013.285141","article-title":"Risk of end-stage renal disease following live kidney donation","volume":"311","author":"Muzaale","year":"2014","journal-title":"JAMA"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1016\/j.mayocp.2022.06.013","article-title":"Long-term Medical Outcomes of Living Kidney Donors","volume":"97","author":"Matas","year":"2022","journal-title":"Mayo Clin. Proc."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e1203","DOI":"10.1136\/bmj.e1203","article-title":"Cardiovascular disease in kidney donors: Matched cohort study","volume":"344","author":"Garg","year":"2012","journal-title":"BMJ"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1053\/j.ajkd.2019.09.015","article-title":"Long-term Mortality Risks Among Living Kidney Donors in Korea","volume":"75","author":"Kim","year":"2020","journal-title":"Am. J. Kidney Dis."},{"key":"ref_15","first-page":"8","article-title":"Prevalence of Coronary Mortality and Morbidity in the Turkish Adult Risk Factor Study: 10-year Follow-up Suggests Coronary \u201cEpidemic\u201d","volume":"29","author":"Onat","year":"2001","journal-title":"Turk Kardiyol. Dern. Ars."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s10654-013-9771-5","article-title":"Twelve-year trends in the prevalence and risk factors of diabetes and prediabetes in Turkish adults","volume":"28","author":"Satman","year":"2013","journal-title":"Eur. J. Epidemiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1053\/j.ajkd.2015.01.019","article-title":"A prospective controlled study of living kidney donors: Three-year follow-up","volume":"66","author":"Kasiske","year":"2015","journal-title":"Am. J. Kidney Dis."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"185","DOI":"10.7326\/0003-4819-145-3-200608010-00006","article-title":"Meta-analysis: Risk for hypertension in living kidney donors","volume":"145","author":"Boudville","year":"2006","journal-title":"Ann. Intern. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1097\/TP.0b013e31817ba9e3","article-title":"Cardiovascular disease and hypertension risk in living kidney donors: An analysis of health administrative data in Ontario, Canada","volume":"86","author":"Garg","year":"2008","journal-title":"Transplantation"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1111\/ajt.14671","article-title":"Causes and timing of end-stage renal disease after living kidney donation","volume":"18","author":"Matas","year":"2018","journal-title":"Am. J. Transplant."},{"key":"ref_21","unstructured":"(2025, July 22). Available online: https:\/\/data.tuik.gov.tr\/Bulten\/Index?p=Turkiye-Saglik-Arastirmasi-2022-49747."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/24\/8908\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T08:58:10Z","timestamp":1765961890000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/24\/8908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,17]]},"references-count":21,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["jcm14248908"],"URL":"https:\/\/doi.org\/10.3390\/jcm14248908","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,17]]}}}