{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:51:04Z","timestamp":1787028664028,"version":"build-2736575974"},"reference-count":30,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: The bolus dose of norepinephrine (NE) for the treatment of spinal anesthesia-induced maternal hypotension remains unclear. The aim of this study was to compare the efficacy and safety of two different bolus doses of NE in the treatment of spinal anesthesia-induced maternal hypotension during cesarean section (CS). Methods: This study has a prospective, randomized and double-blinded design. A total of 150 patients with ASA physical status I and II who underwent CS included the study at a tertiary-care university hospital. Patients were randomly assigned to either the 6 \u00b5g NE bolus (Group 6 \u00b5g, n = 75) or 8 \u00b5g NE bolus (Group 8 \u00b5g, n = 75) group. The primary outcome of this study was to determine the success rate of treatment using a 6 or 8 \u00b5g NE bolus in cases of maternal hypotension. Secondary outcomes included comparing fetal umbilical blood gas values and APGAR scores in neonates born to mothers who received a NE bolus before delivery, determining the incidence of NE-induced reactive bradycardia and hypertension, and comparing the groups for intraoperative nausea and vomiting. Results: The 8 \u00b5g group showed fewer hypotensive episodes (245 vs. 174 episodes, p = 0.012) and required fewer norepinephrine boluses. Additionally, the success rate of hypotension treatment was higher in the 8 \u00b5g group (61.2% vs. 78.5%, p &lt; 0.001). There was no difference in APGAR scores between the groups of neonates born to women who received norepinephrine before delivery. However, in the group with 8 \u00b5g NE, slightly better results were obtained in blood gas samples, excluding the pH value. Nausea was more frequently observed in the 6 \u00b5g group (p = 0.046). Conclusions: We concluded that an 8 \u00b5g bolus administration of NE was more effective than a 6 \u00b5g bolus administration in treating maternal hypotension induced by spinal anesthesia, without any increase in the rate of side effects.<\/jats:p>","DOI":"10.3390\/jcm14248951","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T13:45:07Z","timestamp":1766065507000},"page":"8951","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of Two Different Norepinephrine Bolus Doses for Management of Spinal Anesthesia-Induced Maternal Hypotension in Cesarean Section: A Double-Blind Randomized Controlled Study"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7780-3202","authenticated-orcid":false,"given":"Levent","family":"\u00d6zdemir","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, Mersin University Faculty of Medicine, Mersin 33110, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2215-1518","authenticated-orcid":false,"given":"G\u00f6n\u00fcl Sar\u0131","family":"Pire","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, Dr. Behcet Uz Pediatric Diseases and Surgery Training and Research Hospital, \u0130zmir 35210, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7884-5842","authenticated-orcid":false,"given":"Asl\u0131nur","family":"Sag\u00fcn","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, Mersin University Faculty of Medicine, Mersin 33110, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8266-5203","authenticated-orcid":false,"given":"Mustafa","family":"Azizo\u011flu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, Mersin University Faculty of Medicine, Mersin 33110, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tu\u011fsan Egemen","family":"Bilgin","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, Mersin University Faculty of Medicine, Mersin 33110, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.mpaic.2025.01.012","article-title":"Spinal-induced hypotension at caesarean section","volume":"26","author":"Harrop","year":"2025","journal-title":"Anaesth. 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Australas."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/24\/8951\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T14:00:19Z","timestamp":1766066419000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/14\/24\/8951"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,18]]},"references-count":30,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["jcm14248951"],"URL":"https:\/\/doi.org\/10.3390\/jcm14248951","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,18]]}}}