{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T05:24:13Z","timestamp":1770960253511,"version":"3.50.1"},"reference-count":30,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Introduction: Toxic Epidermal Necrolysis (TEN) and Steven\u2013Johnson Syndrome (SJS) are rare yet dangerous dermatological emergencies presenting as necrosis of the skin and mucous membranes due to an immune reaction which may be associated with the use of pharmaceuticals\u2014predominantly non-steroidal anti-inflammatory drugs (NSAIDs), antibiotics, and antiretroviral drugs. During the postpartum period, women are administered numerous pharmaceuticals, including NSAIDs, analgesics, and antibiotics, due to pain and their susceptibility to infections, exposing them to potential adverse effects including allergies and immune reactions. Case Report and Review: The case reported here is a rare description of a patient in the early postpartum phase who presented with epidermal necrolysis whilst remaining hospitalized after a cesarean delivery. The multidisciplinary approach, early diagnosis, and treatment ensured the patient\u2019s full recovery. Intravenous immunoglobulin treatment resulted in a rapid therapeutic effect. This literature review offers an insight into the epidemiology, diagnostic process, and treatment of this infrequent dermatological syndrome during the postpartum period. Results: Antibiotic treatment is a common culprit of TEN in this population; hence, clinicians should remain vigilant during antibiotic administration. Differential diagnosis with toxic shock syndrome is crucial, as TEN and SJS symptoms may mimic sepsis, which is a more common diagnosis in the postpartum period. Conclusions: The condition of the skin during the postpartum period should be closely monitored, as some systemic diseases may manifest abruptly as profound, postpartum hormonal changes affect the immunological response. Upon the discovery of suspicious skin lesions concomitant with systemic symptoms, an immediate multidisciplinary approach involving obstetricians and dermatologists is key to a rapid diagnosis and treatment to avoid maternal mortality.<\/jats:p>","DOI":"10.3390\/jcm15010017","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T14:27:16Z","timestamp":1766154436000},"page":"17","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Toxic Epidermal Necrolysis and Steven\u2013Johnson Syndrome During the Postpartum Period: A Literature Review with a Rare Case Presentation"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2473-3172","authenticated-orcid":false,"given":"Natalia Katarzyna","family":"Mazur-Ejankowska","sequence":"first","affiliation":[{"name":"Department of Gynecology, Obstetrics and Neonatology, Medical University of Gdansk, 80-210 Gdansk, Poland"},{"name":"Clinic of Obstetrics and Gynecology, Gynecological Oncology and Endocrine Gynecology, University Clinical Centre, 80-952 Gdansk, Poland"},{"name":"First Doctoral School, Medical University of Gdansk, 80-210 Gdansk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maciej","family":"Ejankowski","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Obstetrics and Neonatology, Medical University of Gdansk, 80-210 Gdansk, Poland"},{"name":"Clinic of Obstetrics and Gynecology, Gynecological Oncology and Endocrine Gynecology, University Clinical Centre, 80-952 Gdansk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5311-3450","authenticated-orcid":false,"given":"Magdalena Emilia","family":"Grzybowska","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Obstetrics and Neonatology, Medical University of Gdansk, 80-210 Gdansk, Poland"},{"name":"Clinic of Obstetrics and Gynecology, Gynecological Oncology and Endocrine Gynecology, University Clinical Centre, 80-952 Gdansk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2711-0579","authenticated-orcid":false,"given":"Jakub","family":"\u017b\u00f3\u0142kiewicz","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology, Medical University of Gdansk, 80-210 Gdansk, Poland"},{"name":"Clinic of Dermatology, Venereology and Allergology, University Clinical Centre, 80-952 Gdansk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewa","family":"Gostkowska","sequence":"additional","affiliation":[{"name":"Gynecological and Obstetrical Practice, 80-244 Gdansk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4018-6706","authenticated-orcid":false,"given":"Wioletta","family":"Bara\u0144ska-Rybak","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology, Medical University of Gdansk, 80-210 Gdansk, Poland"},{"name":"Clinic of Dermatology, Venereology and Allergology, University Clinical Centre, 80-952 Gdansk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4510-9558","authenticated-orcid":false,"given":"Dariusz Grzegorz","family":"Wydra","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Obstetrics and Neonatology, Medical University of Gdansk, 80-210 Gdansk, Poland"},{"name":"Clinic of Obstetrics and Gynecology, Gynecological Oncology and Endocrine Gynecology, University Clinical Centre, 80-952 Gdansk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1186\/s40001-025-02664-7","article-title":"Recent developments in the research of Stevens-Johnson syndrome and toxic epidermal necrolysis: Pathogenesis, diagnosis and treatment","volume":"30","author":"Yao","year":"2025","journal-title":"Eur. 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