{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T18:13:37Z","timestamp":1781028817755,"version":"3.54.1"},"reference-count":17,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T00:00:00Z","timestamp":1766534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Mucormycosis is a rapidly progressive invasive fungal infection that commonly involves the sinonasal region and skull base in patients with systemic comorbidities, yet robust ENT data from middle-income settings are scarce. Methods: We performed a single-center retrospective review of all patients with histopathologically confirmed mucormycosis treated in the Otorhinolaryngology Department of Dicle University between 2010 and 2023, covering a 14-year period. Eligible patients had paranasal sinus computed tomography at presentation and received surgical and\/or systemic antifungal therapy. Demographic data, comorbidities, disease subtype, radiological extent, treatment modality and survival were extracted from records. Survival was estimated using Kaplan\u2013Meier analysis, and group differences were tested with chi-square statistics (p \u2264 0.05). Results: Fifty-two patients met the inclusion criteria (mean age 56.5 \u00b1 15.2 years; 57.7% male); 73.1% had at least one systemic comorbidity, most frequently diabetes mellitus (65.4%) and hematological malignancy (19.2%). Disease was sinonasal in 42.3%, rhino-orbital in 28.8% and rhino-orbito-cerebral in 28.8%. Baseline CT showed intracranial extension in 26.9%. Overall survival was 59.6% and differed markedly by subtype, highest in isolated sinonasal disease (81.8%) and lowest in rhino-orbito-cerebral disease (26.7%). Intracranial extension was associated with higher mortality (71.4% vs. 28.9%). Combined surgical debridement plus systemic antifungal therapy, used in 84.6% of patients, yielded lower mortality than antifungal therapy alone (31.8% vs. 87.5%). Conclusions: In this ENT cohort, prognosis was mainly determined by anatomical extent and treatment strategy. Our findings suggest that timely combined surgical and antifungal management, when feasible and in appropriately selected patients, is associated with improved survival outcomes.<\/jats:p>","DOI":"10.3390\/jcm15010127","type":"journal-article","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T11:22:14Z","timestamp":1766575334000},"page":"127","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Impact of Anatomical Extent and Combined Surgical\u2013Medical Therapy on Survival in Sinonasal and Rhino-Orbito-Cerebral Mucormycosis: A 14-Year Retrospective ENT Cohort"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8676-6175","authenticated-orcid":false,"given":"G\u00fcnay","family":"Kozan","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery Clinic, Dicle University Faculty of Medicine, 21010 Diyarbakir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6276-8355","authenticated-orcid":false,"given":"Serkan","family":"Dedeo\u011flu","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, University of Health Sciences Gazi Yasargil Training and Research Hospital, 21100 Diyarbak\u0131r, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2421-4842","authenticated-orcid":false,"given":"Muhammed","family":"Ayral","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery Clinic, Dicle University Faculty of Medicine, 21010 Diyarbakir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Akda\u011f","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery Clinic, Dicle University Faculty of Medicine, 21010 Diyarbakir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/1469-0691.12566","article-title":"Mucormycosis\u2014From the pathogens to the disease","volume":"20","author":"Binder","year":"2014","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1067\/mhn.2002.126587","article-title":"Rhino-orbital and rhino-orbito-cerebral mucormycosis","volume":"127","author":"Talmi","year":"2002","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1007\/s12070-019-01774-z","article-title":"Rhino-Orbital-Cerebral Mucormycosis: Battle with the Deadly Enemy","volume":"72","author":"Gupta","year":"2020","journal-title":"Indian J. Otolaryngol. Head Neck Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1093\/cid\/cir866","article-title":"Epidemiology and Clinical Manifestations of Mucormycosis","volume":"54","author":"Petrikkos","year":"2012","journal-title":"Clin. Infect. Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1470-9465.2004.00843.x","article-title":"Mucormycosis and entomophthoramycosis: A review of the clinical manifestations, diagnosis and treatment","volume":"10","author":"Prabhu","year":"2004","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"161","DOI":"10.22207\/JPAM.13.1.16","article-title":"Mucormycosis: A Brief Review","volume":"13","author":"Ramalingam","year":"2019","journal-title":"J. Pure Appl. Microbiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3492","DOI":"10.1007\/s12070-021-02978-y","article-title":"Rhino-Orbito-Cerebral Mucormycosis During the Second Wave of Covid-19: The Indian Scenario","volume":"74","author":"Bhardwaj","year":"2022","journal-title":"Indian J. Otolaryngol. Head Neck Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"ofae043","DOI":"10.1093\/ofid\/ofae043","article-title":"Epidemiology, Clinical Manifestations, and Outcome of Mucormycosis in Solid Organ Transplant Recipients: A Systematic Review of Reported Cases","volume":"11","author":"Palomba","year":"2024","journal-title":"Open Forum Infect. Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e405","DOI":"10.1016\/S1473-3099(19)30312-3","article-title":"Global guideline for the diagnosis and management of mucormycosis: An initiative of the European Confederation of Medical Mycology in cooperation with the Mycoses Study Group Education and Research Consortium","volume":"19","author":"Cornely","year":"2019","journal-title":"Lancet Infect. Dis."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Kyvernitakis, A., Torres, H.A., Jiang, Y., Chamilos, G., Lewis, R.E., and Kontoyiannis, D.P. (2016). Initial use of combination treatment does not impact survival of 106 patients with haematologic malignancies and mucormycosis: A propensity score analysis. Clin. Microbiol. Infect., 22.","DOI":"10.1016\/j.cmi.2016.03.029"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/1721727X1401200101","article-title":"Rhino-Orbital-Cerebral Mycosis and Cavernous Thrombosis","volume":"12","author":"Li","year":"2014","journal-title":"Eur. J. Inflamm."},{"key":"ref_12","first-page":"619","article-title":"Rhino-orbito-cerebral mucormycosis","volume":"75","author":"Raymundo","year":"2009","journal-title":"Braz. J. Otorhinolaryngol. (Engl. Ed.)"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.cmi.2018.07.011","article-title":"The epidemiology and clinical manifestations of mucormycosis: A systematic review and meta-analysis of case reports","volume":"25","author":"Jeong","year":"2019","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"356","DOI":"10.3341\/kjo.2022.0037","article-title":"Rhino-orbito-cerebral Mucormycosis: Etiopathology, Clinical Features, Outcome, and the Factors Associated with Outcome","volume":"36","author":"Deb","year":"2022","journal-title":"Korean J. Ophthalmol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"295","DOI":"10.5606\/kbbihtisas.2015.45649","article-title":"Rino-orbito-serebral mukormikozis: Literat\u00fcr e\u015fli\u011finde iki olgu sunumu","volume":"25","author":"Kara","year":"2015","journal-title":"Turk. J. Ear Nose Throat"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"867","DOI":"10.18203\/issn.2454-5929.ijohns20211583","article-title":"Case Series A case series of invasive mucormycosis in patients with COVID-19 infection","volume":"7","author":"Mishra","year":"2021","journal-title":"Int. J. Otorhinolaryngol. Head Neck Surg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.idc.2021.03.009","article-title":"Mucormycosis","volume":"35","author":"Steinbrink","year":"2021","journal-title":"Infect. Dis. Clin. N. Am."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/1\/127\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T11:42:09Z","timestamp":1766576529000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/1\/127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,24]]},"references-count":17,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1]]}},"alternative-id":["jcm15010127"],"URL":"https:\/\/doi.org\/10.3390\/jcm15010127","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,24]]}}}