{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:09:01Z","timestamp":1766707741793,"version":"3.48.0"},"reference-count":18,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T00:00:00Z","timestamp":1766620800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Extramammary Paget\u2019s disease (EMPD) is a rare cutaneous adenocarcinoma typically arising on apocrine gland-rich skin. This suprapubic location is exceptionally rare. Its nonspecific erythematous plaques often mimic benign inflammatory or infectious dermatoses, delaying diagnosis. We report an 80-year-old male who presented with a chronic suprapubic plaque. Videodermoscopy and line-field confocal optical coherence tomography (LC-OCT) highlighted irregular vascular patterns and pagetoid cells, raising suspicion for EMPD and guiding a biopsy. Histopathology confirmed carcinoma in situ, and immunostains (CK7 positive, CK20 negative) supported a primary cutaneous origin. Comprehensive screening ruled out associated malignancies; however, guidelines note that colon, rectal, prostate, and bladder cancers are the most frequent synchronous tumors and suggest considering tailored internal malignancy screening. Wide local excision achieved clear margins; after one year, there is no recurrence. The literature indicates that recurrence remains frequent after surgery and may not correlate with margin width, necessitating careful long-term surveillance. For patients unfit for surgery, alternative therapies include radiotherapy, topical imiquimod, and photodynamic therapy, though photodynamic therapy appears palliative rather than curative. Non-invasive imaging modalities, such as LC-OCT, provide high-resolution \u201cvirtual histology,\u201d enhancing early diagnosis and reducing the need for repeated biopsies. Early recognition, appropriate staging, and multidisciplinary management are crucial for improving outcomes.<\/jats:p>","DOI":"10.3390\/jcm15010160","type":"journal-article","created":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T23:52:27Z","timestamp":1766706747000},"page":"160","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Extramammary Paget\u2019s Disease of the Suprapubic Region in a Male: A Novel Diagnostic Imaging Approach and Literature Review"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3775-8021","authenticated-orcid":false,"given":"Piotr","family":"Sobolewski","sequence":"first","affiliation":[{"name":"Dermatology Clinic, National Medical Institute of the Ministry of Interior and Administration, 02-507 Warsaw, Poland"},{"name":"Chair and Clinic of Dermatology and Pediatric Dermatology, Centre of Postgraduate Medical Education, 02-507 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1048-2774","authenticated-orcid":false,"given":"Mateusz","family":"Koper","sequence":"additional","affiliation":[{"name":"Dermatology Clinic, National Medical Institute of the Ministry of Interior and Administration, 02-507 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7204-4278","authenticated-orcid":false,"given":"Malgorzata","family":"Kolos","sequence":"additional","affiliation":[{"name":"Pathomorphological Center, National Institute of Medicine of the Ministry of Interior and Administration, 02-507 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3502-3339","authenticated-orcid":false,"given":"Irena","family":"Walecka","sequence":"additional","affiliation":[{"name":"Dermatology Clinic, National Medical Institute of the Ministry of Interior and Administration, 02-507 Warsaw, Poland"},{"name":"Chair and Clinic of Dermatology and Pediatric Dermatology, Centre of Postgraduate Medical Education, 02-507 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1590\/abd1806-4841.20153189","article-title":"Mammary and extramammary Paget\u2019s disease","volume":"90","author":"Lopes","year":"2015","journal-title":"An. 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(2021). The Outcome of Chemotherapy for Metastatic Extramammary Paget\u2019s Disease. J. Clin. Med., 10.","DOI":"10.3390\/jcm10040739"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"6647","DOI":"10.18632\/oncotarget.27272","article-title":"Sequential somatic mutations upon secondary anti-HER2 treatment resistance in metastatic ERBB2(S310F) mutated extramammary Paget\u2019s disease","volume":"10","author":"Nordmann","year":"2019","journal-title":"Oncotarget"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1159\/000514345","article-title":"Treatment of Metastatic Extramammary Paget Disease with Combination Ipilimumab and Nivolumab: A Case Report","volume":"14","author":"Guercio","year":"2021","journal-title":"Case Rep. Oncol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Diet, G., Lenoir, C., Fontaine, M., Boussingault, L., Orte Cano, C., Mtimet, L., Li\u00e9nard, D., Sanak, D., Moulart, F., and Bernardi, D. (2024). 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Diagnostics, 14.","DOI":"10.20944\/preprints202407.0743.v1"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/1\/160\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:08:05Z","timestamp":1766707685000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/1\/160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,25]]},"references-count":18,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1]]}},"alternative-id":["jcm15010160"],"URL":"https:\/\/doi.org\/10.3390\/jcm15010160","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,25]]}}}