{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T06:01:16Z","timestamp":1793944876805,"version":"4.8.0"},"reference-count":41,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"French Ministry of Education, Research and Innovation","award":["Doctoral Fellowship"],"award-info":[{"award-number":["Doctoral Fellowship"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Recent preclinical studies suggest that acute exercise induces immune modulation, enhances tumor blood perfusion, and is associated with reduced tumor growth. Adding exercise to immunochemotherapy treatment (ICT) has been proposed as a strategy to increase treatment effectiveness. The ERICA trial (NCT04676009) aimed to assess the feasibility of acute aerobic exercise performed immediately before the administration of ICT in patients with metastatic non-small cell lung cancer (mNSCLC) and to explore hypothesis-generating outcomes related to physical fitness and patient-reported outcomes. Methods: Newly diagnosed mNSCLC patients were randomly assigned (2:1) to the exercise or control group. The exercise intervention included supervised acute exercise before each of four ICT cycles plus a 3-month home-based walking program with an activity tracker and step goals. The feasibility of the exercise protocol was assessed through adherence, acceptability, tolerability, and safety. Clinical, physical, and patient-reported outcomes were assessed at baseline and after 3 months. Results: Twenty-six patients (mean age 60.6 years; SD 10.65) participated, with an 87.5% acceptance rate. In the exercise group (n = 17), 80.9% of participants completed the acute exercise sessions, with a median interval of 38 min [IQR, 20\u201360] between exercise and ICT. No exercise-related adverse effects were reported. After 3 months, 60% of participants in the exercise group were classified as active and maintained their step goals. Self-reported measures suggest that maintaining physical fitness is favorable for reducing fatigue and insomnia, and therefore improving quality of life. Conclusions: Acute exercise performed immediately before each ICT administration in patients with mNSCLC appears feasible and safe.<\/jats:p>","DOI":"10.3390\/jcm15010334","type":"journal-article","created":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T11:11:46Z","timestamp":1767352306000},"page":"334","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Feasibility and Preliminary Efficacy of Aerobic Acute Exercise Prior to Immunotherapy and Chemotherapy Infusion in Patients with Metastatic Non-Small Cell Lung Cancer: A Randomized Controlled Trial"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0877-269X","authenticated-orcid":false,"given":"Manon","family":"Gouez","sequence":"first","affiliation":[{"name":"Department of Cancer Prevention and Environment, L\u00e9on B\u00e9rard Cancer Center, 69008 Lyon, France"},{"name":"Inter-University Laboratory of Human Movement Biology EA7424, University Claude Bernard Lyon 1, University of Lyon, 69622 Villeurbanne, France"},{"name":"1296 Unit Radiations: Defense, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), Health and Environnement, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7543-7050","authenticated-orcid":false,"given":"Olivia","family":"P\u00e9rol","sequence":"additional","affiliation":[{"name":"Department of Cancer Prevention and Environment, L\u00e9on B\u00e9rard Cancer Center, 69008 Lyon, France"},{"name":"1296 Unit Radiations: Defense, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), Health and Environnement, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2057-061X","authenticated-orcid":false,"given":"Vincent","family":"Pialoux","sequence":"additional","affiliation":[{"name":"Inter-University Laboratory of Human Movement Biology EA7424, University Claude Bernard Lyon 1, University of Lyon, 69622 Villeurbanne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5508-557X","authenticated-orcid":false,"given":"Virginie","family":"Avrillon","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, L\u00e9on B\u00e9rard Cancer Center, 69008 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Boussageon","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, L\u00e9on B\u00e9rard Cancer Center, 69008 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantal","family":"Decroisette","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, L\u00e9on B\u00e9rard Cancer Center, 69008 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1240-5390","authenticated-orcid":false,"given":"Lidia","family":"Delrieu","sequence":"additional","affiliation":[{"name":"Residual Tumor & Response to Treatment Laboratory, RT2Lab, Translational Research Department, INSERM, U932 Immunity and Cancer, Institut Curie, Paris, France"},{"name":"IRMES, Institute for Research in Biomedicine and Epidemiology of Sport, UPR7329, Universit\u00e9 Paris Cit\u00e9, Paris, France"},{"name":"INSEP, Institut National du Sport, de l\u2019Expertise et de la Performance, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7613-8354","authenticated-orcid":false,"given":"Houssein","family":"El Hajj","sequence":"additional","affiliation":[{"name":"Department of Cancer Prevention and Environment, L\u00e9on B\u00e9rard Cancer Center, 69008 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1309-5390","authenticated-orcid":false,"given":"Baptiste","family":"Fournier","sequence":"additional","affiliation":[{"name":"Department of Cancer Prevention and Environment, L\u00e9on B\u00e9rard Cancer Center, 69008 Lyon, France"},{"name":"1296 Unit Radiations: Defense, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), Health and Environnement, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1465-2814","authenticated-orcid":false,"given":"Romane","family":"Gille","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, L\u00e9on B\u00e9rard Cancer Center, 69008 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3850-8291","authenticated-orcid":false,"given":"Mathilde","family":"His","sequence":"additional","affiliation":[{"name":"Department of Cancer Prevention and Environment, L\u00e9on B\u00e9rard Cancer Center, 69008 Lyon, France"},{"name":"1296 Unit Radiations: Defense, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), Health and Environnement, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0895-1001","authenticated-orcid":false,"given":"B\u00e9n\u00e9dicte","family":"Mastroianni","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, L\u00e9on B\u00e9rard Cancer Center, 69008 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0552-2118","authenticated-orcid":false,"given":"Aur\u00e9lie","family":"Swalduz","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, L\u00e9on B\u00e9rard Cancer Center, 69008 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3296-423X","authenticated-orcid":false,"given":"Maurice","family":"P\u00e9rol","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, L\u00e9on B\u00e9rard Cancer Center, 69008 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3498-6499","authenticated-orcid":false,"given":"B\u00e9atrice","family":"Fervers","sequence":"additional","affiliation":[{"name":"Department of Cancer Prevention and Environment, L\u00e9on B\u00e9rard Cancer Center, 69008 Lyon, France"},{"name":"1296 Unit Radiations: 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