{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:21:38Z","timestamp":1783556498915,"version":"3.55.0"},"reference-count":62,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Acute coronary syndrome (ACS) continues to be a major contributor to morbidity and mortality worldwide. While percutaneous coronary interventions (PCIs) have significantly evolved, coronary artery bypass grafting (CABG) has retained a role in emergency revascularization. Nevertheless, ongoing debate persists about how to select candidates for surgery, when to operate, and which surgical techniques offer the greatest safety and efficacy. Methods: A comprehensive literature search was conducted, yielding 2302 records, of which 25 studies met predefined screening criteria and were included for detailed analysis. Given that timing remains one of the most controversial issues in the management of ACS, our primary aim was to determine the optimal timing for CABG in this patient population. Additionally, we examined how preoperative antiplatelet therapy and the presence of cardiogenic shock influence clinical outcomes, and what revascularization strategy may be most appropriate for these patients. Results: Of the 2302 initially identified studies, 25 were selected for a detailed analysis, supplemented by 28 additional key references. Among the included studies, 17 focused primarily on the effects of surgical timing and 8 on comparisons between the outcomes of CABG and PCI. The analysis comprised 15 database or multicentre retrospective cohort studies, 8 single-centre retrospective studies, and 2 prospective investigations. Conclusion and limitations: Although the topic of non-elective coronary surgery has been with us for several decades, a number of inherent biases hinder thorough statistical investigation in this complex population. Although a number of contradictory findings hinder drawing simple conclusions, being reluctant to perform early surgery solely based on poorer unfiltered outcomes might miss a point.<\/jats:p>","DOI":"10.3390\/jcm15020560","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T08:20:37Z","timestamp":1768206037000},"page":"560","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Comprehensive Review of Acute Coronary Syndrome and Bypass Surgery: Recent Advances, Timing, and Indicative Considerations"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5835-638X","authenticated-orcid":false,"given":"L\u0151rinc","family":"Holczer","sequence":"first","affiliation":[{"name":"Heart Institute, Medical School, University of P\u00e9cs, 7624 Pecs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1820-5560","authenticated-orcid":false,"given":"L\u00e1szl\u00f3","family":"Hejjel","sequence":"additional","affiliation":[{"name":"Heart Institute, Medical School, University of P\u00e9cs, 7624 Pecs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2162-6155","authenticated-orcid":false,"given":"Istv\u00e1n","family":"Szokodi","sequence":"additional","affiliation":[{"name":"Heart Institute, Medical School, University of P\u00e9cs, 7624 Pecs, Hungary"},{"name":"Szent\u00e1gothai Research Center, University of P\u00e9cs, 7624 Pecs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5911-2774","authenticated-orcid":false,"given":"Attila","family":"K\u00f3nyi","sequence":"additional","affiliation":[{"name":"Heart Institute, Medical School, University of P\u00e9cs, 7624 Pecs, Hungary"},{"name":"Szent\u00e1gothai Research Center, University of P\u00e9cs, 7624 Pecs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e618","DOI":"10.1161\/CIR.0000000000000617","article-title":"Fourth universal definition of myocardial infarction","volume":"138","author":"Thygesen","year":"2018","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e139","DOI":"10.1016\/j.jacc.2014.09.017","article-title":"2014 AHA\/ACC Guideline for the Management of Patients with Non-ST-Elevation Acute Coronary Syndromes: A report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines","volume":"64","author":"Amsterdam","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1136\/hrt.2005.084830","article-title":"Intervention in acute coronary syndromes: Do patients undergo intervention on the basis of their risk characteristics? The Global Registry of Acute Coronary Events (GRACE)","volume":"93","author":"Fox","year":"2007","journal-title":"Heart"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S0140-6736(17)31490-3","article-title":"Optimal timing of an invasive strategy in patients with non-ST-elevation acute coronary syndrome: A meta-analysis of randomised trials","volume":"390","author":"Jobs","year":"2017","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.1016\/j.jacc.2021.09.006","article-title":"2021 ACC\/AHA\/SCAI Guideline for Coronary Artery Revascularization: A Report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"79","author":"Lawton","year":"2022","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"I414","DOI":"10.1161\/CIRCULATIONAHA.105.000661","article-title":"Outcome of patients with low ejection fraction undergoing coronary artery bypass grafting: Renal function and mortality after 3.8 years","volume":"114","author":"Hillis","year":"2006","journal-title":"Circulation"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1001\/jamainternmed.2024.7694","article-title":"Heterogeneity of Primary Outcomes in Large Atherosclerotic Cardiovascular Disease Trials Published in Prominent Medical Journals","volume":"185","author":"Shepshelovich","year":"2025","journal-title":"JAMA Intern. Med."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Lang, Q., Qin, C., and Meng, W. (2022). Appropriate Timing of Coronary Artery Bypass Graft Surgery for Acute Myocardial Infarction Patients: A Meta-Analysis. Front. Cardiovasc. Med., 9.","DOI":"10.3389\/fcvm.2022.794925"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.athoracsur.2015.10.051","article-title":"Clinical Characteristics and Outcomes of Patients With Myocardial Infarction and Cardiogenic Shock Undergoing Coronary Artery Bypass Surgery: Data from the Society of Thoracic Surgeons National Database","volume":"101","author":"Acharya","year":"2016","journal-title":"Ann. Thorac. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.ejcts.2005.12.021","article-title":"Influence of time elapsed between myocardial infarction and coronary artery bypass grafting surgery on operative mortality","volume":"29","author":"Voisine","year":"2006","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.jtcvs.2007.10.042","article-title":"Optimal timing of coronary artery bypass after acute myocardial infarction: A review of California discharge data","volume":"135","author":"Weiss","year":"2008","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/S0003-4975(01)02425-0","article-title":"Optimal Timing of Revascularization: Transmural Versus Nontransmural Acute Myocardial Infarction","volume":"71","author":"Lee","year":"2001","journal-title":"Ann. Thorac. Surg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1067\/mtc.2003.75","article-title":"Appropriate timing of surgical intervention after transmural acute myocardial infarction","volume":"125","author":"Lee","year":"2003","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e24325","DOI":"10.1002\/clc.24325","article-title":"Optimal Revascularization Timing of Coronary Artery Bypass Grafting in Acute Myocardial Infarction","volume":"47","author":"Kim","year":"2024","journal-title":"Clin. Cardiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s13019-020-01134-x","article-title":"Delay in coronary artery bypass grafting for STEMI patients improves hospital morbidity and mortality","volume":"15","author":"Lemaire","year":"2020","journal-title":"J. Cardiothorac. Surg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.ijcard.2022.04.067","article-title":"Implications of elevated troponin on time-to-surgery in non-ST elevation myocardial infarction (NIHR Health Informatics Collaborative: TROP-CABG study)","volume":"1","author":"Benedetto","year":"2022","journal-title":"Int. J. Cardiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"I448","DOI":"10.1161\/CIRCULATIONAHA.105.001057","article-title":"Prognostic value of preoperative cardiac troponin I in patients undergoing emergency coronary artery bypass surgery with non-ST-elevation or ST-elevation acute coronary syndromes","volume":"114","author":"Thielmann","year":"2006","journal-title":"Circulation"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"4444","DOI":"10.21037\/jtd.2019.11.08","article-title":"Early surgical myocardial revascularization in non-ST-segment elevation acute coronary syndrome","volume":"11","author":"Rojas","year":"2019","journal-title":"J. Thorac. Dis."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e021182","DOI":"10.1161\/JAHA.121.021182","article-title":"Coronary Artery Bypass Graft Surgery in Patients With Acute Coronary Syndromes After Primary Percutaneous Coronary Intervention: A Current Report from the North-Rhine Westphalia Surgical Myocardial Infarction Registry","volume":"10","author":"Thielmann","year":"2021","journal-title":"J. Am. Heart Assoc."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.jcin.2010.01.012","article-title":"Timing of in-hospital coronary artery bypass graft surgery for non-ST-segment elevation myocardial infarction patients results from the National Cardiovascular Data Registry ACTION Registry-GWTG (Acute Coronary Treatment and Intervention Outcomes Network Registry-Get with the Guidelines)","volume":"3","author":"Parikh","year":"2010","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1161\/CIRCULATIONAHA.119.040631","article-title":"Assessment and Treatment of Patients with Type 2 Myocardial Infarction and Acute Non-Ischemic Myocardial Injury","volume":"140","author":"DeFilippis","year":"2019","journal-title":"Circulation"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1007\/s11886-020-01386-y","article-title":"Re-evaluating the Role of CABG in Acute Coronary Syndromes","volume":"22","author":"Farmer","year":"2020","journal-title":"Curr. Cardiol. Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S0140-6736(18)30423-9","article-title":"Mortality after coronary artery bypass grafting versus percutaneous coronary intervention with stenting for coronary artery disease: A pooled analysis of individual patient data","volume":"391","author":"Head","year":"2018","journal-title":"Lancet"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1093\/eurheartj\/ehae700","article-title":"Percutaneous vs. surgical revascularization of non-ST-segment elevation myocardial infarction with multivessel disease: The SWEDEHEART registry","volume":"46","author":"Omerovic","year":"2025","journal-title":"Eur. Heart J."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ijcard.2020.01.040","article-title":"Temporal trends of patients with acute coronary syndrome and multi-vessel coronary artery disease-from the ACSIS registry","volume":"304","author":"Shiyovich","year":"2020","journal-title":"Int. J. Cardiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1056\/NEJMoa1211585","article-title":"Strategies for multivessel revascularization in patients with diabetes","volume":"367","author":"Farkouh","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1016\/j.hlc.2024.02.014","article-title":"Impact of Diabetes in Patients With Acute Myocardial Infarction Undergoing Coronary Artery Bypass Surgery Within 48 Hours","volume":"33","author":"Huenges","year":"2024","journal-title":"Heart Lung Circ."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/eurheartj\/ehy394","article-title":"2018 ESC\/EACTS Guidelines on myocardial revascularization","volume":"40","author":"Neumann","year":"2018","journal-title":"Eur. Heart J."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Peker, T., and Boyraz, B. (2023). Short-Term Prognostic Value of the Culprit-SYNTAX Score in Patients with Acute Myocardial Infarction. J. Cardiovasc. Dev. Dis., 10.","DOI":"10.3390\/jcdd10070270"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1093\/ejcts\/ezs043","article-title":"EuroSCORE II","volume":"41","author":"Nashef","year":"2012","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1016\/j.amjcard.2016.08.024","article-title":"Meta-Analysis Comparing Established Risk Prediction Models (EuroSCORE II, STS Score, and ACEF Score) for Perioperative Mortality During Cardiac Surgery","volume":"118","author":"Sullivan","year":"2016","journal-title":"Am. J. Cardiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.athoracsur.2016.01.105","article-title":"Comparison of EuroSCORE II, Original EuroSCORE, and The Society of Thoracic Surgeons Risk Score in Cardiac Surgery Patients","volume":"102","author":"Ad","year":"2016","journal-title":"Ann. Thorac. Surg."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1093\/ejcts\/ezu045","article-title":"EuroSCORE II with SYNTAX score to assess risks of coronary artery bypass grafting outcomes","volume":"47","author":"Fukui","year":"2015","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"ref_34","first-page":"219","article-title":"The SYNTAX Score: An angiographic tool grading the complexity of coronary artery disease","volume":"1","author":"Sianos","year":"2005","journal-title":"EuroIntervention"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1056\/NEJMoa0804626","article-title":"Percutaneous Coronary Intervention versus Coronary-Artery Bypass Grafting for Severe Coronary Artery Disease","volume":"360","author":"Serruys","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S0140-6736(15)60213-6","article-title":"Clinical evidence for oral antiplatelet therapy in acute coronary syndromes","volume":"386","author":"Wiviott","year":"2015","journal-title":"Lancet"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1161\/CIRCULATIONAHA.107.728147","article-title":"Clinical characteristics and in-hospital outcomes of patients with cardiogenic shock undergoing coronary artery bypass surgery: Insights from the Society of Thoracic Surgeons National Cardiac Database","volume":"117","author":"Mehta","year":"2008","journal-title":"Circulation"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"210","DOI":"10.21037\/acs-2021-ami-19","article-title":"Effects of concomitant coronary artery bypass grafting on early and late mortality in the treatment of post-infarction mechanical complications: A systematic review and meta-analysis","volume":"11","author":"Ronco","year":"2022","journal-title":"Ann. Cardiothorac. Surg."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1016\/j.jacc.2020.07.064","article-title":"Surgeons\u2019 Coronary Bypass Practice Patterns in the United States","volume":"76","author":"Gaudino","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1093\/icvts\/ivx276","article-title":"Mortality and morbidity of patients on the waiting list for coronary artery bypass graft surgery","volume":"26","author":"Tura","year":"2018","journal-title":"Interact. Cardiovasc. Thorac. Surg."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1016\/j.athoracsur.2021.05.057","article-title":"Timing of Coronary Artery Bypass Grafting in Acute Coronary Syndrome: A National Analysis","volume":"113","author":"Hadaya","year":"2022","journal-title":"Ann Thorac Surg."},{"key":"ref_42","first-page":"012049","article-title":"Early Clinical Outcomes of Surgical Myocardial Revascularization for Acute Coronary Syndromes Complicated by Cardiogenic Shock: A Report From the North-Rhine-Westphalia Surgical Myocardial Infarction Registry","volume":"119","author":"Liakopoulos","year":"2019","journal-title":"JAHA"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.xjon.2024.05.008","article-title":"Timing of coronary artery bypass grafting after myocardial infarction influences late survival","volume":"20","author":"Patlolla","year":"2024","journal-title":"JTCVS Open"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1016\/j.jcin.2019.04.039","article-title":"Temporal Trends and Outcomes of Mechanical Complications in Patients with Acute Myocardial Infarction","volume":"12","author":"Elbadawi","year":"2019","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.carrev.2018.03.017","article-title":"Common themes in patients requiring urgent cardiothoracic surgery after percutaneous coronary interventions: Case series and review of the literature","volume":"19","author":"Ezad","year":"2018","journal-title":"Cardiovasc. Revasc. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1111\/jocs.14539","article-title":"Revascularization following non-ST elevation myocardial infarction in multivessel coronary disease","volume":"35","author":"Huckaby","year":"2020","journal-title":"J. Card. Surg."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.athoracsur.2023.05.032","article-title":"Contemporary Coronary Artery Bypass Grafting versus Multivessel Percutaneous Coronary Intervention","volume":"116","author":"Mehaffey","year":"2023","journal-title":"Ann. Thorac. Surg."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Paparella, D., Scrascia, G., Paramythiotis, A., Guida, P., Magari, V., Malvindi, P.G., Favale, S., and Tupputi Schinosa, L.L. (2010). Preoperative Cardiac Troponin I to Assess Midterm Risks of Coronary Bypass Grafting Operations in Patients With Recent Myocardial Infarction. Ann. Thorac. Surg., 89, 696\u2013703.","DOI":"10.1016\/j.athoracsur.2009.11.072"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1093\/eurheartj\/ehz425","article-title":"2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes: The Task Force for the diagnosis and management of chronic coronary syndromes of the European Society of Cardiology (ESC)","volume":"41","author":"Knuuti","year":"2019","journal-title":"Eur. Heart J."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1056\/NEJMe1902214","article-title":"Refining Antithrombotic Therapy for Atrial Fibrillation and Acute Coronary Syndromes or PCI","volume":"380","author":"Mehta","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.athoracsur.2003.05.007","article-title":"Mortality on the waiting list for coronary artery bypass grafting: Incidence and risk factors","volume":"77","author":"Rexius","year":"2004","journal-title":"Ann. Thorac. Surg."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1093\/icvts\/ivt128","article-title":"Does early coronary artery bypass surgery improve survival in non-ST acute myocardial infarction?","volume":"17","author":"Dayan","year":"2013","journal-title":"Interact. Cardiovasc. Thorac. Surg."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"120","DOI":"10.2459\/JCM.0000000000000621","article-title":"Early myocardial surgical revascularization after ST-segment elevation myocardial infarction in multivessel coronary disease: Bridge therapy is the solution?","volume":"19","author":"Polito","year":"2018","journal-title":"J. Cardiovasc. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1001\/jamasurg.2024.7066","article-title":"Early vs delayed bypass surgery in patients with acute coronary syndrome receiving ticagrelor: The RAPID CABG randomized open-label noninferiority trial","volume":"160","author":"So","year":"2025","journal-title":"JAMA Surg."},{"key":"ref_55","first-page":"100122","article-title":"Cangrelor in STEMI as a bridge to CABG-a mini-case series","volume":"13","author":"Shrestha","year":"2022","journal-title":"Am. Heart J. Plus"},{"key":"ref_56","first-page":"CD007398","article-title":"Intra-aortic balloon pump counterpulsation (IABP) for myocardial infarction complicated by cardiogenic shock","volume":"2015","author":"Unverzagt","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1016\/j.jacc.2018.07.074","article-title":"Cardiac Shock Care Centers: JACC Review Topic of the Week","volume":"72","author":"Rab","year":"2018","journal-title":"JACC"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"ezae355","DOI":"10.1093\/ejcts\/ezae355","article-title":"2024 EACTS Guidelines on perioperative medication in adult cardiac surgery","volume":"67","author":"Jeppsson","year":"2024","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1001\/jamacardio.2020.6814","article-title":"Assessing the Risks of Bleeding vs Thrombotic Events in Patients at High Bleeding Risk After Coronary Stent Implantation: The ARC-High Bleeding Risk Trade-off Model","volume":"6","author":"Urban","year":"2021","journal-title":"JAMA Cardiol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1016\/j.athoracsur.2016.03.090","article-title":"Predicting Likelihood for Coronary Artery Bypass Grafting After Non-ST-Elevation Myocardial Infarction: Finding the Best Prediction Model","volume":"102","author":"Shafiq","year":"2016","journal-title":"Ann. Thorac. Surg."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jjcc.2024.08.002","article-title":"Optimal management of high bleeding risk patients undergoing percutaneous coronary interventions: Where do we stand?","volume":"85","author":"Dimitriadis","year":"2025","journal-title":"J. Cardiol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0735-1097(21)01504-7","article-title":"Systematic review of bias in non-randomized studies on the optimal timing of coronary artery bypass grafting following acute coronary syndrome","volume":"77","author":"Weigel","year":"2021","journal-title":"J. Am. Coll. Cardiol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/2\/560\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T06:29:44Z","timestamp":1768458584000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/2\/560"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,9]]},"references-count":62,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,1]]}},"alternative-id":["jcm15020560"],"URL":"https:\/\/doi.org\/10.3390\/jcm15020560","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,9]]}}}