{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T17:37:26Z","timestamp":1788025046469,"version":"build-2784847793"},"reference-count":38,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Oral lichen planus (OLP) is a chronic inflammatory autoimmune disease. Certain clinical forms of the disease may cause significant discomfort and negatively impact patients\u2019 quality of life. The first-line treatment is topical corticosteroids. The purpose of this narrative review is to evaluate the influence of corticosteroid injections in the treatment of OLP. Methods: A search of the literature was conducted in October 2025 using the following databases: PubMed, Web of Science, Scopus, and Cochrane. Results: Fifteen studies were evaluated. Injections with triamcinolone acetonide at a concentration of 10\u201340 mg\/mL at weekly intervals demonstrated efficacy in reducing pain and healing OLP lesions in these studies. They showed minor adverse effects. Conclusions: Noting the limitations of this narrative review, intralesional corticosteroid injections are an effective and safe method of treating OLP. They should be considered in patients with symptomatic OLP.<\/jats:p>","DOI":"10.3390\/jcm15020561","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T08:20:37Z","timestamp":1768206037000},"page":"561","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Intralesional Corticosteroid Injections in the Treatment of Oral Lichen Planus\u2014A Narrative Review"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8708-8538","authenticated-orcid":false,"given":"Weronika","family":"Miazga-Rychlik","sequence":"first","affiliation":[{"name":"Department of Periodontology and Oral Mucosa Diseases, Medical University of Warsaw, 6 Binieckiego St., 02-097 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilia","family":"Milczarek","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Oral Mucosa Diseases, Medical University of Warsaw, 6 Binieckiego St., 02-097 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Kowalski","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Oral Mucosa Diseases, Medical University of Warsaw, 6 Binieckiego St., 02-097 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7368-574X","authenticated-orcid":false,"given":"Aniela","family":"Brodzikowska","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry, Medical University of Warsaw, 6 Binieckiego St., 02-097 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3918-4332","authenticated-orcid":false,"given":"Bart\u0142omiej","family":"G\u00f3rski","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Oral Mucosa Diseases, Medical University of Warsaw, 6 Binieckiego St., 02-097 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1111\/odi.13323","article-title":"Worldwide prevalence of oral lichen planus: A systematic review and meta-analysis","volume":"27","author":"Warnakulasuriya","year":"2021","journal-title":"Oral Dis."},{"key":"ref_2","first-page":"e938","article-title":"Oral Lichen Planus and Its Relationship with Systemic Diseases: A Review of Evidence","volume":"10","year":"2018","journal-title":"J. Clin. Exp. Dent."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.clindermatol.2016.02.023","article-title":"Oral Lichen Planus","volume":"34","author":"Olson","year":"2016","journal-title":"Clin. Dermatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s00403-016-1667-2","article-title":"Oral Lichen Planus: A Literature Review and Update","volume":"308","author":"Alrashdan","year":"2016","journal-title":"Arch. Dermatol. Res."},{"key":"ref_5","first-page":"661","article-title":"Rate of Malignant Transformation of Oral Lichen Planus: A Systematic Review","volume":"24","author":"Giuliani","year":"2018","journal-title":"Oral Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1111\/jdv.16464","article-title":"European S1 Guidelines on the Management of Lichen Planus: A Cooperation of the European Dermatology Forum with the European Academy of Dermatology and Venereology","volume":"34","author":"Ioannides","year":"2020","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"377","DOI":"10.2334\/josnusd.50.377","article-title":"Steroids in the Treatment of Lichen Planus: A Review","volume":"50","author":"Thongprasom","year":"2008","journal-title":"J. Oral Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/j.1600-0714.2006.00441.x","article-title":"Short term clinical evaluation of intralesional triamcinolone acetonide injection for ulcerative oral lichen planus","volume":"35","author":"Xia","year":"2006","journal-title":"J. Oral Pathol. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/j.1600-0714.2009.00796.x","article-title":"The Efficacy of Topical Intralesional BCG PSN Injection in the Treatment of Erosive Oral Lichen Planus: A Randomized Controlled Trial","volume":"38","author":"Xiong","year":"2009","journal-title":"J. Oral Pathol. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4103\/ejdv.ejdv_12_17","article-title":"Bacillus Calmette Gu\u00e9rin polysaccharide nucleic acid extract versus triamcinolone acetonide intralesional injection in the treatment of oral lichen planus: A comparative study","volume":"38","author":"Metwalli","year":"2018","journal-title":"Egypt. J. Dermatol. Venereol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1177\/0194599812473237","article-title":"Intralesional injection versus mouth rinse of triamcinolone acetonide in oral lichen planus: A randomized controlled study","volume":"148","author":"Lee","year":"2013","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.oooo.2013.07.023","article-title":"Efficacy of intralesional betamethasone for erosive oral lichen planus and evaluation of recurrence: A randomized, controlled trial","volume":"116","author":"Liu","year":"2013","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.jobcr.2020.09.008","article-title":"Comparative Evaluation of Effectiveness of Autologous Platelet Rich Plasma and Intralesional Corticosteroids in the Management of Erosive Oral Lichen Planus\u2014A Clinical Study","volume":"10","author":"Ahuja","year":"2020","journal-title":"J. Oral Biol. Craniofac. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1111\/jocd.15622","article-title":"Intralesional Injection of Platelet Rich Plasma Versus Steroid in the Treatment of Oral Lichen Planus","volume":"22","author":"ElGhareeb","year":"2023","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3747","DOI":"10.1007\/s00784-020-03702-w","article-title":"Efficacy of Platelet Rich Fibrin Compared with Triamcinolone Acetonide as Injective Therapy in the Treatment of Symptomatic Oral Lichen Planus: A Pilot Study","volume":"25","author":"Bennardo","year":"2021","journal-title":"Clin. Oral Investig."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1111\/odi.14261","article-title":"Efficacy of Injectable Platelet Rich Fibrin in the Treatment of Symptomatic Oral Lichen Planus","volume":"29","author":"Hamadah","year":"2023","journal-title":"Oral Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1016\/j.ijom.2021.02.028","article-title":"Decreased recurrence of symptoms in oral lichen planus with intralesional injection of hyaluronic acid and triamcinolone","volume":"50","author":"Atyabi","year":"2021","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Zhao, W., Lin, D., Deng, S., Wang, S., Guo, Y., Yang, J., Shi, X., and Zhou, H. (2022). Synergistic Efficacy of Plaque Control with Intralesional Triamcinolone Acetonide Injection on Erosive Non Gingival Oral Lichen Planus: A Randomized Controlled Clinical Trial. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph192113787"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.jfma.2012.01.014","article-title":"Prompt healing of erosive oral lichen planus lesion after combined corticosteroid treatment with locally injected triamcinolone acetonide plus oral prednisolone","volume":"112","author":"Kuo","year":"2013","journal-title":"J. Formos. Med. Assoc."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"205","DOI":"10.21053\/ceo.2017.01319","article-title":"Factors Affecting the Result of Intralesional Corticosteroid Injection in Patients with Oral Lichen Planus","volume":"11","author":"Lee","year":"2018","journal-title":"Clin. Exp. Otorhinolaryngol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"236","DOI":"10.4103\/ccd.ccd_899_20","article-title":"Clinical Evaluation of Efficacy of Triamcinolone Acetonide with Tacrolimus in the Management of Oral Lichen Planus: A Pilot Prospective Observational Study","volume":"13","author":"Walia","year":"2022","journal-title":"Contemp. Clin. Dent."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e13015","DOI":"10.1111\/dth.13015","article-title":"Corticosteroid Injection in Treatment of Persistent Oral Lichen Planus: Three Cases","volume":"32","author":"Kurt","year":"2019","journal-title":"Dermatol. Ther."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s40257-023-00814-3","article-title":"Oral Lichen Planus: An Update on Diagnosis and Management","volume":"25","author":"Louisy","year":"2024","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.4103\/jpbs.JPBS_91_17","article-title":"Systemic and Topical Steroids in the Management of Oral Mucosal Lesions","volume":"9","author":"Kiran","year":"2017","journal-title":"J. Pharm. Bioallied Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4103\/srmjrds.srmjrds_138_22","article-title":"Applications of corticosteroids in oral diseases\u2014A narrative review","volume":"14","author":"Lohokare","year":"2023","journal-title":"SRM J. Res. Dent. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/j.1365-2753.2008.01028.x","article-title":"Professional Attitudes toward Oral Lichen Planus: Need for National and International Guidelines","volume":"15","year":"2009","journal-title":"J. Eval. Clin. Pract."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1177\/154405910508400401","article-title":"Vesiculo-Erosive Oral Mucosal Disease\u2014Management with Topical Corticosteroids: (1) Fundamental Principles and Specific Agents Available","volume":"84","author":"Scully","year":"2005","journal-title":"J. Dent. Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1111\/odi.12634","article-title":"Interventions for the Management of Oral Lichen Planus: A Review of the Conventional and Novel Therapies","volume":"23","author":"Gupta","year":"2017","journal-title":"Oral Dis."},{"key":"ref_29","unstructured":"Gabros, S., Nessel, T.A., and Zito, P.M. (2025, December 27). Topical Corticosteroids, StatPearls, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK532940\/."},{"key":"ref_30","first-page":"e827","article-title":"The use of topical corticoids in oral pathology","volume":"15","year":"2010","journal-title":"Med. Oral Patol. Oral Cir. Bucal"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1034\/j.1600-0714.2003.00173.x","article-title":"Systemic and Topical Corticosteroid Treatment of Oral Lichen Planus: A Comparative Study","volume":"32","author":"Carbone","year":"2003","journal-title":"J. Oral Pathol. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"S40","DOI":"10.1111\/j.1834-7819.2005.tb00385.x","article-title":"Topical corticosteroids in dental practice","volume":"50","author":"Savage","year":"2005","journal-title":"Austral. Dent. J."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.3892\/etm.2020.9328","article-title":"Treatment Trends in Oral Lichen Planus and Oral Lichenoid Lesions (Review)","volume":"20","author":"Rotaru","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e12761","DOI":"10.1111\/eos.12761","article-title":"Corticosteroid delivery using oral mucosa equivalents for the treatment of inflammatory mucosal diseases","volume":"129","author":"Said","year":"2021","journal-title":"Eur. J. Oral Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.oooo.2019.07.024","article-title":"Intralesional Triamcinolone Acetonide Therapy for Inflammatory Oral Ulcers","volume":"128","author":"Fantozzi","year":"2019","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.jaad.2007.11.022","article-title":"Betamethasone Oral Mini-Pulse Therapy Compared with Topical Triamcinolone Acetonide (0.1%) Paste in Oral Lichen Planus: A Randomized Comparative Study","volume":"58","author":"Malhotra","year":"2008","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"3136","DOI":"10.1111\/odi.14447","article-title":"Disease severity scoring systems in mucosal lichen planus: A systematic review","volume":"29","author":"Unnikrishnan","year":"2022","journal-title":"Oral Dis."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Gan, W. (2025). Impact of Sample Size and Its Estimation in Medical Research. AJPM Focus, in press.","DOI":"10.1016\/j.focus.2025.100451"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/2\/561\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T06:34:22Z","timestamp":1768458862000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/2\/561"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,9]]},"references-count":38,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,1]]}},"alternative-id":["jcm15020561"],"URL":"https:\/\/doi.org\/10.3390\/jcm15020561","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,9]]}}}