{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T19:15:48Z","timestamp":1777662948542,"version":"3.51.4"},"reference-count":122,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Hyperbaric oxygen therapy (HBOT) is considered a potential adjunctive modality to enhance tissue regeneration in oral and maxillofacial surgery. By increasing tissue oxygen availability, HBOT may support bone and soft-tissue repair under hypoxic and chronically inflamed conditions. Aim: This narrative review evaluates current experimental and clinical evidence regarding HBOT in high-risk dental indications, including osteoradionecrosis (ORN), medication-related osteonecrosis of the jaw (MRONJ), chronic osteomyelitis, poorly healing postoperative wounds, and procedures in patients with systemic comorbidities. Methods: A structured search of PubMed, Web of Science, and the Cochrane Library identified 123 relevant English-language publications (from 1 January 2000\u2013September 2025) addressing HBOT mechanisms and clinical applications in oral and maxillofacial surgery, including clinical trials, observational studies, preclinical models, and systematic reviews. Results: Available evidence suggests that HBOT may improve healing outcomes and reduce complication rates in early-stage ORN and MRONJ when used as an adjunct to surgery and systemic therapy. However, findings in implantology\u2014particularly in irradiated or diabetic patients\u2014and in periodontal therapy remain limited, heterogeneous, and methodologically inconsistent. Conclusions: HBOT may be considered in selected clinical scenarios, particularly where healing is impaired by hypoxia or systemic disease. Nevertheless, current evidence remains insufficient to support routine use. Standardized, high-quality studies with clearly defined endpoints and uniform therapeutic protocols are needed to determine its clinical effectiveness and optimal indications.<\/jats:p>","DOI":"10.3390\/jcm15020605","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T10:25:23Z","timestamp":1768213523000},"page":"605","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["HBOT as a Potential Adjunctive Therapy for Wound Healing in Dental Surgery\u2014A Narrative Review"],"prefix":"10.3390","volume":"15","author":[{"given":"Beata","family":"Wi\u015bniewska","sequence":"first","affiliation":[{"name":"Department of Oral Surgery, Periodontology and Oral Mucosa Diseases, Poznan University of Medical Sciences, 10 Fredry Street, 61-701 Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosma","family":"Piekarski","sequence":"additional","affiliation":[{"name":"Arbor Vitae Society of Ethics in Medicine, 103 Marymoncka Street, 01-813 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Spycha\u0142a","sequence":"additional","affiliation":[{"name":"Arbor Vitae Society of Ethics in Medicine, 103 Marymoncka Street, 01-813 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9520-2670","authenticated-orcid":false,"given":"Ewelina","family":"Golusi\u0144ska-Kardach","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery, Periodontology and Oral Mucosa Diseases, Poznan University of Medical Sciences, 10 Fredry Street, 61-701 Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2398-9571","authenticated-orcid":false,"given":"Bart\u0142omiej","family":"Perek","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, 61-701 Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marzena Liliana","family":"Wyganowska","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery, Periodontology and Oral Mucosa Diseases, Poznan University of Medical Sciences, 10 Fredry Street, 61-701 Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"200223","DOI":"10.1098\/rsob.200223","article-title":"Wound healing: Cellular mechanisms and pathological outcomes","volume":"10","author":"Wilkinson","year":"2020","journal-title":"Open Biol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"265sr266","DOI":"10.1126\/scitranslmed.3009337","article-title":"Wound repair and regeneration: Mechanisms, signaling, and translation","volume":"6","author":"Eming","year":"2014","journal-title":"Sci. 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