{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T20:02:26Z","timestamp":1789243346649,"version":"build-2803163510"},"reference-count":40,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Acute kidney injury (AKI) is a frequent and clinically relevant complication in cancer patients, with highly variable incidence. AKI increases morbidity and mortality, prolongs hospitalization, and may limit access to oncologic therapies. This study evaluated the incidence, risk factors, and outcomes of AKI in hospitalized cancer patients. Methods: We retrospectively analyzed patients admitted between 1 January 2016 and 31 December 2019. Individuals with cancer were identified and categorized into three groups: hematologic malignancies, solid cancers with metastases, and solid cancers without metastases. Demographic, clinical, and laboratory data were collected, and AKI was defined and staged according to KDIGO criteria, evaluating serum creatinine changes. Results: Among 56,390 hospitalized patients, 6723 (11.9%) had a cancer diagnosis. AKI incidence was significantly higher in cancer versus non-cancer patients (30.1% vs. 19.6%). Hematologic cancers showed the highest incidence (39.3%). Among hematologic patients, ICU admission, sepsis, and diabetes were strongly associated with AKI. In non-metastatic solid cancers, more conventional factors\u2014including female sex, older age, sepsis, and ICU admission\u2014were significant predictors. In contrast, in metastatic solid cancers, traditional AKI risk factors did not correlate with increased AKI occurrence. In cancer patients overall, AKI per se did not increase mortality risk; however, stage 3 AKI was associated with significantly higher mortality (HR 1.37, 95% CI 1.13\u20131.66, p &lt; 0.001). Conclusions: AKI is common in hospitalized cancer patients, with specific patterns and heterogeneous risk factors and impact on outcomes. Implementation of tailored preventive strategies and early recognition are necessary to mitigate progression and improve clinical trajectories.<\/jats:p>","DOI":"10.3390\/jcm15020690","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T08:26:36Z","timestamp":1768465596000},"page":"690","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Acute Kidney Injury in Hospitalized Cancer Patients: Single-Centre Real-Life Analysis of Incidence and Clinical Impact"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0834-5586","authenticated-orcid":false,"given":"Pasquale","family":"Esposito","sequence":"first","affiliation":[{"name":"Unit of Nephrology, Dialysis and Transplantation, IRCCS Azienda Ospedaliera Metropolitana (IRCCS AOM) San Martino, 16132 Genoa, Italy"},{"name":"Department of Internal Medicine and Medical Specialties (DIMI), University of Genova, Viale Benedetto XV, 16132 Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Cappadona","sequence":"additional","affiliation":[{"name":"Unit of Nephrology, Dialysis and Transplantation, IRCCS Azienda Ospedaliera Metropolitana (IRCCS AOM) San Martino, 16132 Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annarita","family":"Bottini","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Medical Specialties (DIMI), University of Genova, Viale Benedetto XV, 16132 Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1279-3178","authenticated-orcid":false,"given":"Elisa","family":"Russo","sequence":"additional","affiliation":[{"name":"Unit of Nephrology, Dialysis and Transplantation, IRCCS Azienda Ospedaliera Metropolitana (IRCCS AOM) San Martino, 16132 Genoa, Italy"},{"name":"Department of Internal Medicine and Medical Specialties (DIMI), University of Genova, Viale Benedetto XV, 16132 Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6432-2429","authenticated-orcid":false,"given":"Giacomo","family":"Garibotto","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Medical Specialties (DIMI), University of Genova, Viale Benedetto XV, 16132 Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4120-3555","authenticated-orcid":false,"given":"Vincenzo","family":"Cantaluppi","sequence":"additional","affiliation":[{"name":"Nephrology and Kidney Transplantation Unit, Department of Translational Medicine (DIMET), University of Piemonte Orientale (UPO), AOU Maggiore Della Carit\u00e0, 28100 Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4219-7043","authenticated-orcid":false,"given":"Francesca","family":"Viazzi","sequence":"additional","affiliation":[{"name":"Unit of Nephrology, Dialysis and Transplantation, IRCCS Azienda Ospedaliera Metropolitana (IRCCS AOM) San Martino, 16132 Genoa, Italy"},{"name":"Department of Internal Medicine and Medical Specialties (DIMI), University of Genova, Viale Benedetto XV, 16132 Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1159\/000540908","article-title":"Acute Kidney Disease in Oncology: A New Concept to Enhance the Understanding of the Impact of Kidney Injury in Patients with Cancer","volume":"49","author":"Floris","year":"2024","journal-title":"Kidney Blood Press. 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