{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T22:17:24Z","timestamp":1768601844871,"version":"3.49.0"},"reference-count":173,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Univ of Iowa Department of Otolaryngology","award":["Schilling Resident Research Grant"],"award-info":[{"award-number":["Schilling Resident Research Grant"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Audiovestibular disorders arising from the inner ear (e.g., hearing loss, tinnitus, vertigo) are widely prevalent in the United States. Yet, medical treatments targeting the underlying pathology of these disorders remain scarce. The practice of repurposing FDA-approved drugs for new therapeutic indications has become increasingly common, offering a lower risk route to treatment development with fewer barriers to implementation, as safety profiles are already established. The renin\u2013angiotensin system (RAS) is well known for its role in blood pressure and fluid balance, and its overactivation induces acute and chronic inflammation and oxidative stress. This review discusses existing evidence and proposed otoprotective mechanisms of RAS inhibition, specifically using angiotensin II type 1 receptor blockers (ARBs), which support the repurposing of these medications as novel treatments to affect the inner ear pathologies that underlay hearing loss, tinnitus, and vertigo.<\/jats:p>","DOI":"10.3390\/jcm15020743","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T11:39:37Z","timestamp":1768563577000},"page":"743","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Repurposing Renin\u2013Angiotensin System Drugs for the Treatment of Audiovestibular Disorders"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0960-5065","authenticated-orcid":false,"given":"Grant","family":"Podhajsky","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Head & Neck Surgery, University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiran S.","family":"Marla","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head & Neck Surgery, University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alec P.","family":"Marticoff","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head & Neck Surgery, University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2858-1225","authenticated-orcid":false,"given":"Kenny","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head & Neck Surgery, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7559-2771","authenticated-orcid":false,"given":"Tanner","family":"Kempton","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head & Neck Surgery, University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sepehr","family":"Salehpour","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head & Neck Surgery, University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caden","family":"Duffy","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head & Neck Surgery, University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3394-7164","authenticated-orcid":false,"given":"Douglas M.","family":"Bennion","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head & Neck Surgery, University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1093\/gerona\/glr002","article-title":"Hearing loss prevalence and risk factors among older adults in the United States","volume":"66","author":"Lin","year":"2011","journal-title":"J. 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