{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T23:38:23Z","timestamp":1780443503871,"version":"3.54.1"},"reference-count":70,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Blood thinners (anticoagulants) remain the first line pharmacotherapy for the management of cardiovascular and thromboembolic disorders. The increased utilization of polypharmacy, likely driven by the greater burden of comorbidities, elevates the risk of potential drug\u2013drug interactions (pDDIs) and creates a significant challenge in anticoagulant management. The aim of the study was to assess the prescribing trend and impact of polypharmacy and pDDIs in patients receiving anticoagulant drug therapy in a public hospital providing secondary care. Methods: A cross-sectional observational study was undertaken between January\u2013June 2023. Data from electronic medical records of prescriptions for anticoagulants were collected, analyzed for prescribing patterns, and checked for pDDIs using Micromedex database 2.0\u00ae. Utilizing binary logistic regression, the relationship between polypharmacy and sociodemographic factors was assessed. Multivariate logistic regression analysis served to uncover determinants linked to pDDIs. Results: Of the total 130 patients, females were predominant (58.46%), with a higher prevalence among those aged 61\u201390 years. Atrial fibrillation emerged as the main clinical reason and apixaban (51.53%) ranked as the top prescribed anticoagulant in our cohort. Among the 766 pDDIs identified, the majority [401 (52.34%)] were categorized as moderate in severity. Polypharmacy was strongly linked to age (p = 0.001), the Charlson comorbidity index (CCI) (p = 0.040), and comorbidities (p = 0.005) in the binary logistic regression analysis. In the multivariable analysis, the number of medications remain a strong predictor of pDDIs (adjusted OR: 30.514, p = 0.001). Conclusions: Polypharmacy and pDDIs were exhibited in a significant segment of cohort receiving anticoagulant therapy, with strong correlations to age, CCI, comorbidities, and the number of medications. A multidimensional approach involving collaboration among healthcare providers assisted by clinical decision support systems can help optimize the management of polypharmacy, minimize the risks of pDDIs, and ultimately enhance health outcomes.<\/jats:p>","DOI":"10.3390\/jcm15020800","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T09:24:34Z","timestamp":1768901074000},"page":"800","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prescribing Practices, Polypharmacy, and Drug Interaction Risks in Anticoagulant Therapy: Insights from a Secondary Care Hospital"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5892-5909","authenticated-orcid":false,"given":"Javedh","family":"Shareef","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy & Pharmacology, RAK College of Pharmacy, RAK Medical & Health Sciences University, Ras Al Khaimah 11172, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9100-2508","authenticated-orcid":false,"given":"Sathvik Belagodu","family":"Sridhar","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy & Pharmacology, RAK College of Pharmacy, RAK Medical & Health Sciences University, Ras Al Khaimah 11172, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shadi Ahmed","family":"Hamouda","sequence":"additional","affiliation":[{"name":"Ibrahim Bin Hamad Obaidallah Hospital, Emirates Health Services, Ras Al Khaimah 11172, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahsan","family":"Ali","sequence":"additional","affiliation":[{"name":"Internal Medicine, Ibrahim Bin Hamad Obaidallah Hospital, Emirates Health Services, Ras Al Khaimah 11172, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajith Cherian","family":"Thomas","sequence":"additional","affiliation":[{"name":"Internal Medicine, Ibrahim Bin Hamad Obaidallah Hospital, Emirates Health Services, Ras Al Khaimah 11172, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,19]]},"reference":[{"key":"ref_1","unstructured":"Amaraneni, A., Chippa, V., Goldin, J., and Rettew, A.C. (2024, October 06). Anticoagulation Safety, StatPearls, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK519025\/."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e1425","DOI":"10.1002\/hsr2.1425","article-title":"Assessment of prescribing pattern and adverse drug reaction in patients receiving anticoagulant therapy: A prospective observational study","volume":"6","author":"Vijayakumar","year":"2023","journal-title":"Health Sci. Rep."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1007\/s12094-020-02506-4","article-title":"Cancer and Thrombosis Section of the Spanish Society of Medical Oncology (SEOM). Direct oral anticoagulants for the treatment and prevention of venous thromboembolism in patients with cancer: Current evidence","volume":"23","year":"2021","journal-title":"Clin. Transl. Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41397-024-00329-y","article-title":"Being precise with anticoagulation to reduce adverse drug reactions: Are we there yet?","volume":"24","author":"Cross","year":"2024","journal-title":"Pharmacogenomics J."},{"key":"ref_5","first-page":"e6947","article-title":"Non-Clinical Factors Associated with International Normalized Ratio Control in Patients on Warfarin Therapy: A Review Paper","volume":"7","author":"Ramasamy","year":"2020","journal-title":"Open Access Libr. J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s43162-023-00212-5","article-title":"An update on applications and limitations of direct oral anticoagulants","volume":"35","author":"Wei","year":"2023","journal-title":"Egypt. J. Intern. Med."},{"key":"ref_7","first-page":"k2505","article-title":"Risks and benefits of direct oral anticoagulants versus warfarin in a real-world setting: Cohort study in primary care","volume":"362","author":"Page","year":"2018","journal-title":"BMJ"},{"key":"ref_8","first-page":"e007956","article-title":"Drug Interactions Affecting Oral Anticoagulant Use","volume":"15","author":"Mar","year":"2022","journal-title":"Circ. Arrhythm. Electrophysiol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Aggarwal, P., Woolford, S.J., and Patel, H.P. (2020). Multi-Morbidity and Polypharmacy in Older People: Challenges and Opportunities for Clinical Practice. Geriatrics, 5.","DOI":"10.20944\/preprints202009.0030.v1"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Ye, L., Yang-Huang, J., Franse, C.B., Rukavina, T., Vasiljev, V., Mattace-Raso, F., Verma, A., Borr\u00e1s, T.A., Rentoumis, T., and Raat, H. (2022). Factors associated with polypharmacy and the high risk of medication-related problems among older community-dwelling adults in European countries: A longitudinal study. BMC Geriatr., 22.","DOI":"10.1186\/s12877-022-03536-z"},{"key":"ref_11","unstructured":"(2025, January 24). The Dangers of Polypharmacy and the Case for Deprescribing in Older Adults. Research Highlights, Available online: https:\/\/www.nia.nih.gov\/news\/dangers-polypharmacy-and-case-deprescribing-older-adults."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1007\/s40520-022-02165-1","article-title":"Prevalence and impact of polypharmacy in older patients with type 2 diabetes","volume":"34","author":"Remelli","year":"2022","journal-title":"Aging Clin. Exp. Res."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Hammar, T., Hamqvist, S., Zetterholm, M., Jokela, P., and Ferati, M. (2021). Current Knowledge about Providing Drug-Drug Interaction Services for Patients-A Scoping Review. Pharmacy, 9.","DOI":"10.3390\/pharmacy9020069"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"375","DOI":"10.4330\/wjc.v15.i8.375","article-title":"Proton pump inhibitors and gastroprotection in patients treated with antithrombotic drugs: A cardiologic point of view","volume":"15","author":"Abrignani","year":"2023","journal-title":"World J. Cardiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1111\/jphp.12983","article-title":"Effects of medicines used to treat gastrointestinal diseases on the pharmacokinetics of coadministered drugs: A PEARRL Review","volume":"71","author":"Litou","year":"2019","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/s41392-023-01619-w","article-title":"Drug-microbiota interactions: An emerging priority for precision medicine","volume":"8","author":"Zhao","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.2147\/DDDT.S149069","article-title":"The cytochrome P450 isoenzyme and some new opportunities for the prediction of negative drug interaction in vivo","volume":"12","author":"Sychev","year":"2018","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"368504211070183","DOI":"10.1177\/00368504211070183","article-title":"Prevalence of polypharmacy and risk of potential drug-drug interactions among hospitalized patients with emphasis on the pharmacokinetics","volume":"105","author":"Georgiev","year":"2022","journal-title":"Sci. Prog."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s41999-021-00479-3","article-title":"Polypharmacy in older adults: A narrative review of definitions, epidemiology and consequences","volume":"12","author":"Pazan","year":"2021","journal-title":"Eur. Geriatr. Med."},{"key":"ref_20","unstructured":"(2023, June 15). IBM Micromedex\u00ae Drug Interactions. IBM Corporation; Greenwood Village, CO, USA. Version 2.0. Available online: https:\/\/www.micromedexsolutions.com."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1016\/j.dsx.2020.10.022","article-title":"CCI and a composite of poor outcomes in COVID-19 patients: A systematic review and meta-analysis","volume":"14","author":"Kuswardhani","year":"2020","journal-title":"Diabetes Metab. Syndr."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.thromres.2020.07.054","article-title":"The increased risk of bleeding due to drug-drug interactions in patients administered direct oral anticoagulants","volume":"195","author":"Lee","year":"2020","journal-title":"Thromb. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1177\/2042098617719815","article-title":"Potential drug-drug interactions with direct oral anticoagulants in elderly hospitalized patients","volume":"8","author":"Forbes","year":"2017","journal-title":"Ther. Adv. Drug Saf."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"509","DOI":"10.2147\/CIA.S358633","article-title":"Medication Appropriateness, Polypharmacy, and Drug-Drug Interactions in Ambulatory Elderly Patients with Cardiovascular Diseases at Tikur Anbessa Specialized Hospital, Ethiopia","volume":"17","author":"Adem","year":"2022","journal-title":"Clin. Interv. Aging"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.glohj.2023.02.002","article-title":"The role of drug utilization evaluation in medical sciences","volume":"7","author":"Gangwar","year":"2023","journal-title":"Glob. Health J."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e081628","DOI":"10.1136\/bmjopen-2023-081628","article-title":"Disparities in the real-world prescription pattern of oral anticoagulants for US Medicare beneficiaries: A geospatial analysis","volume":"14","author":"Zou","year":"2024","journal-title":"BMJ Open."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1111\/bcp.15582","article-title":"Trends in oral anticoagulant use in patients with atrial fibrillation in Belgium from 2013 to 2019: A nationwide cohort study","volume":"89","author":"Grymonprez","year":"2023","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"87","DOI":"10.2147\/IJGM.S129235","article-title":"Utilization and prescribing patterns of direct oral anticoagulants","volume":"10","author":"Whitworth","year":"2017","journal-title":"Int. J. Gen. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1111\/bcp.14464","article-title":"Patterns and factors influencing oral anticoagulant prescription in people with atrial fibrillation and dementia: Results from UK primary care","volume":"87","author":"Mongkhon","year":"2021","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1002\/joa3.12607","article-title":"Effectiveness and safety of non-vitamin K antagonist oral anticoagulants in patients with non-valvular atrial fibrillation: A nationwide, population-based study in Korea","volume":"37","author":"Han","year":"2021","journal-title":"J. Arrhythm."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/jcpt.13538","article-title":"A drug utilization study of oral anticoagulants in five representative cities of China between 2015 and 2019","volume":"47","author":"Gong","year":"2022","journal-title":"J. Clin. Pharm. Ther."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Mezhal, F., Oulhaj, A., Abdulle, A., AlJunaibi, A., Alnaeemi, A., Ahmad, A., Leinberger-Jabari, A., Al Dhaheri, A.S., AlZaabi, E., and Al-Maskari, F. (2023). High prevalence of cardiometabolic risk factors amongst young adults in the United Arab Emirates: The UAE Healthy Future Study. BMC Cardiovasc. Disord., 23.","DOI":"10.1186\/s12872-023-03165-3"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"BJGPO.2022.0179","DOI":"10.3399\/BJGPO.2022.0179","article-title":"Pattern of oral anticoagulant prescribing for atrial fibrillation in general practice: An observational study in The Netherlands","volume":"7","author":"Kager","year":"2023","journal-title":"BJGP Open."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e007129","DOI":"10.1161\/JAHA.117.007129","article-title":"Temporal Trends in the Use and Comparative Effectiveness of Direct Oral Anticoagulant Agents Versus Warfarin for Nonvalvular Atrial Fibrillation: A Canadian Population-Based Study","volume":"6","author":"Yu","year":"2017","journal-title":"J. Am. Heart Assoc."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/s41572-022-00376-4","article-title":"Multimorbidity","volume":"8","author":"Skou","year":"2022","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1111\/jth.14467","article-title":"Evaluating utilization patterns of oral anticoagulants in routine care","volume":"17","author":"Gopalakrishnan","year":"2019","journal-title":"J. Thromb. Haemost."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e026863","DOI":"10.1161\/JAHA.122.026863","article-title":"Prescribing Trends of Oral Anticoagulants in US Patients With Cirrhosis and Nonvalvular Atrial Fibrillation","volume":"12","author":"Simon","year":"2023","journal-title":"J. Am. Heart Assoc."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1007\/s11239-021-02416-4","article-title":"Prescribing trends of oral anticoagulants in England over the last decade: A focus on new and old drugs and adverse events reporting","volume":"52","author":"Afzal","year":"2021","journal-title":"J. Thromb. Thrombolysis."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Mitchell, A., Snowball, J., Welsh, T.J., Watson, M.C., and McGrogan, A. (2021). Prescribing of direct oral anticoagulants and warfarin to older people with atrial fibrillation in UK general practice: A cohort study. BMC Med., 19.","DOI":"10.1186\/s12916-021-02067-5"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.1007\/s12325-022-02151-z","article-title":"Drug Utilization Pattern of Oral Anticoagulants in Patients with Atrial Fibrillation: A Nationwide Population-Based Study in Korea","volume":"39","author":"Lee","year":"2022","journal-title":"Adv. Ther."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e2137288","DOI":"10.1001\/jamanetworkopen.2021.37288","article-title":"Clinician Trends in Prescribing Direct Oral Anticoagulants for US Medicare Beneficiaries","volume":"4","author":"Wheelock","year":"2021","journal-title":"JAMA Netw. Open."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"10742484221142220","DOI":"10.1177\/10742484221142220","article-title":"Prescribing Patterns of Direct-Acting Oral Anticoagulants in Patients With Atrial Fibrillation and Chronic Kidney Disease: A Retrospective Cohort Analysis","volume":"27","author":"Reyes","year":"2022","journal-title":"J. Cardiovasc. Pharmacol. Ther."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s12471-021-01612-4","article-title":"Prescription patterns of direct oral anticoagulants and concomitant use of interacting medications in the Netherlands","volume":"29","author":"Harskamp","year":"2021","journal-title":"Neth. Heart J."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.2147\/DDDT.S203112","article-title":"Dabigatran must be used carefully: Literature review and recommendations for management of adverse events","volume":"13","author":"Lin","year":"2019","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e786","DOI":"10.1002\/hsr2.786","article-title":"Drug-related problems among hospitalized hypertensive and heart failure patients and physician acceptance of pharmacists\u2019 interventions at a teaching hospital in Ghana","volume":"5","author":"Harrison","year":"2022","journal-title":"Health Sci. Rep."},{"key":"ref_46","unstructured":"National Guideline Centre (UK) (2025, November 28). Anticoagulant Therapy for Stroke Prevention in People with Atrial Fibrillation: Atrial Fibrillation: Diagnosis and Management: Evidence Review G1, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK571345\/."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Rieckert, A., Trampisch, U.S., Klaa\u00dfen-Mielke, R., Drewelow, E., Esmail, A., Johansson, T., Keller, S., Kunnamo, I., L\u00f6ffler, C., and M\u00e4kinen, J. (2018). Polypharmacy in older patients with chronic diseases: A cross-sectional analysis of factors associated with excessive polypharmacy. BMC Fam. Pract., 19.","DOI":"10.1186\/s12875-018-0795-5"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Wang, Y., Li, X., Jia, D., Lin, B., Fu, B., Qi, B., and Zhang, Z. (2021). Exploring polypharmacy burden among elderly patients with chronic diseases in Chinese community: A cross-sectional study. BMC Geriatr., 21.","DOI":"10.1186\/s12877-021-02247-1"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Kardas, P., Lichwierowicz, A., Urba\u0144ski, F., Chudzy\u0144ska, E., Czech, M., and Kardas, G. (2021). Prevalence of Chronic Polypharmacy in Community-Dwelling Elderly People in Poland: Analysis of National Real-World Database Helps to Identify High Risk Group. Front. Pharmacol., 12.","DOI":"10.3389\/fphar.2021.739740"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Alhumaidi, R.M., Bamagous, G.A., Alsanosi, S.M., Alqashqari, H.S., Qadhi, R.S., Alhindi, Y.Z., Ayoub, N., and Falemban, A.H. (2023). Risk of Polypharmacy and Its Outcome in Terms of Drug Interaction in an Elderly Population: A Retrospective Cross-Sectional Study. J. Clin. Med., 12.","DOI":"10.3390\/jcm12123960"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Wang, H., Shi, H., Wang, N., Wang, Y., Zhang, L., Zhao, Y., and Xie, J. (2022). Prevalence of potential drug-drug interactions in the cardiothoracic intensive care unit patients in a Chinese tertiary care teaching hospital. BMC Pharmacol. Toxicol., 23.","DOI":"10.1186\/s40360-022-00582-6"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Eneh, P.C., Hullsiek, K.H., Kiiza, D., Rhein, J., Meya, D.B., Boulware, D.R., and Nicol, M.R. (2020). Prevalence and nature of potential drug-drug interactions among hospitalized HIV patients presenting with suspected meningitis in Uganda. BMC Infect. Dis., 20.","DOI":"10.1186\/s12879-020-05296-w"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jsps.2019.11.009","article-title":"The prevalence and severity of potential drug-drug interactions among adult polypharmacy patients at outpatient clinics in Jordan","volume":"28","author":"Nusair","year":"2020","journal-title":"Saudi Pharm. J."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s40261-020-00982-8","article-title":"Concomitant Use of Direct Oral Anticoagulants and Antiepileptic Drugs: A Prospective Cohort Study in Patients with Atrial Fibrillation","volume":"41","author":"Giustozzi","year":"2021","journal-title":"Clin. Drug Investig."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Wannawichate, T., and Limpawattana, P. (2023). Potential Drug-Drug Interactions and Related Factors among Geriatric Outpatients of a Tertiary Care Hospital. Geriatrics, 8.","DOI":"10.3390\/geriatrics8060111"},{"key":"ref_56","first-page":"1","article-title":"Survey on Polypharmacy and Drug-Drug Interactions Among Elderly People with Cardiovascular Diseases at Yekatit 12 Hospital, Addis Ababa, Ethiopia","volume":"9","author":"Assefa","year":"2020","journal-title":"Integr. Pharm. Res. Pract."},{"key":"ref_57","first-page":"262","article-title":"Prevalence of Warfarin Drug Interaction and Warfarin Education Practice in Outpatient Setups of University Teaching Hospital: A Retrospective Chart Review and an Observational Study","volume":"9","author":"Tadesse","year":"2018","journal-title":"J. Basic. Clin. Pharma"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s40261-024-01369-9","article-title":"Drug-Drug Interactions and Their Association with Adverse Health Outcomes in the Older Community-Dwelling Population: A Prospective Cohort Study","volume":"44","author":"Hughes","year":"2024","journal-title":"Clin. Drug Investig."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1080\/07853890.2020.1799241","article-title":"Impact of multimorbidity and polypharmacy on the management of patients with atrial fibrillation: Insights from the BALKAN-AF survey","volume":"53","author":"Simovic","year":"2021","journal-title":"Ann. Med."},{"key":"ref_60","first-page":"100056","article-title":"Potential drug interactions in adults living in the Brazilian Amazon: A population-based case-control study, 2019","volume":"3","author":"Biase","year":"2021","journal-title":"Explor. Res. Clin. Soc. Pharm."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"625","DOI":"10.23736\/S2724-5683.24.06546-3","article-title":"Italian Registry in the Setting of Atrial Fibrillation Ablation with Rivaroxaban\u2014IRIS","volume":"72","author":"Lavalle","year":"2024","journal-title":"Minerva Cardiol. Angiol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1002\/clc.23196","article-title":"Anticoagulation in chronic kidney disease: From guidelines to clinical practice","volume":"42","author":"Aursulesei","year":"2019","journal-title":"Clin. Cardiol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"93","DOI":"10.4103\/ajm.ajm_228_20","article-title":"Patient characteristics, adherence and costs of oral anticoagulation therapy in non-valvular atrial fibrillation using the Dubai Real-World Claims Database","volume":"11","author":"Ghorab","year":"2021","journal-title":"Avicenna J. Med."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1111\/jce.16598","article-title":"The Atrial Fibrillation Registry (The FLOW-AF Registry): Insights From the United Arab Emirates-Patient Characteristics, Treatment, and One-Year Outcomes","volume":"36","author":"AlMuti","year":"2025","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"33","DOI":"10.2174\/1874220301906010033","article-title":"Profiling Clinical Characteristics and Treatment Patterns Among Non-Valvular Atrial Fibrillation Patients: A Real-World Analysis in Dubai, United Arab Emirates","volume":"6","author":"Bazargani","year":"2019","journal-title":"Open Med. J."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s40246-022-00417-9","article-title":"Pharmacogenomics implementation in cardiovascular disease in a highly diverse population: Initial findings and lessons learned from a pilot study in United Arab Emirates","volume":"16","author":"Khasawneh","year":"2022","journal-title":"Hum. Genom."},{"key":"ref_67","first-page":"2741","article-title":"Assessment of knowledge and counseling practice of warfarin among pharmacists in UAE: A cross-sectional study","volume":"20","author":"Alkherat","year":"2022","journal-title":"Pharm. Pract."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.15537\/smj.2015.11.12154","article-title":"Clinical utility of dabigatran in United Arab Emirates. A pharmacovigilance study","volume":"36","author":"Shehab","year":"2015","journal-title":"Saudi Med. J."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Ayash, B., Malaeb, D., Hallit, S., and Hosseini, H. (2024). Assessing adherence to treatment guidelines and complications among atrial fibrillation patients in the United Arab Emirates. Front. Cardiovasc. Med., 11.","DOI":"10.3389\/fcvm.2024.1359922"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s13098-021-00758-w","article-title":"The interrelationship and accumulation of cardiometabolic risk factors amongst young adults in the United Arab Emirates: The UAE Healthy Future Study","volume":"13","author":"Mezhal","year":"2021","journal-title":"Diabetol. Metab. Syndr."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/2\/800\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T09:48:32Z","timestamp":1768902512000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/2\/800"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,19]]},"references-count":70,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,1]]}},"alternative-id":["jcm15020800"],"URL":"https:\/\/doi.org\/10.3390\/jcm15020800","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,19]]}}}