{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:20:10Z","timestamp":1790882410466,"version":"4.1.0"},"reference-count":13,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Objectives: The HOSTILE score was developed to assess femoral access challenges in transcatheter valve therapy. Similar vascular issues arise in femoral cannulation for minimally invasive valve surgery, making CT-based planning essential. We adapted the score for surgical use (MOD-HOSTILE) and evaluated its association with neurological and adverse outcomes. Methods: In this single-center retrospective study, the MOD-HOSTILE score (0\u201311 points) was calculated for 364 patients undergoing minimally invasive heart valve surgery from 2019 to 2023. Patients were stratified into low (0\u20132), mild (&gt;2\u20135), and high (&gt;5\u201311) score categories. Outcomes included 30-day stroke, other neurological events, and perioperative complications. Results: High MOD-HOSTILE patients were significantly older (70 [64.7\u201373.0] vs. 61 [60.0\u201363.0] years; p &lt; 0.01) and had higher surgical risk (EuroSCORE II 1.79 [1.26\u20132.16] vs. 0.83 [0.75\u20130.94]; p &lt; 0.01). Neurological complications were more frequent in the high MOD-HOSTILE group, including stroke (8.7% vs. 0.9%; p = 0.02) and hemiplegia (13.0% vs. 0.9%; p &lt; 0.01). Axillary cannulated patients had higher MOD-HOSTILE scores than femoral cannulated patients. Stroke risk was highest in patients with high MOD-HOSTILE score undergoing axillary cannulation (high vs. low MOD-HOSTILE, 18.2% vs. 0%; p = 0.04). Thirty-day mortality was comparable between groups (p = 0.09). MOD-HOSTILE predicted stroke with an AUC of 0.78 (95% CI 0.73\u20130.82) and OR 1.4 per point (95% CI 1.1\u20132.0). Conclusions: The MOD-HOSTILE score identifies vascular and neurological risk in minimally invasive valve surgery, with scores \u22655 indicating elevated risk of stroke and delirium. Patients with high scores may benefit from alternative surgical strategies.<\/jats:p>","DOI":"10.3390\/jcm15020843","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T14:57:58Z","timestamp":1768921078000},"page":"843","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Risk Assessment in Cannulation for Minimally Invasive Heart Valve Surgery: The Modified HOSTILE Score"],"prefix":"10.3390","volume":"15","author":[{"given":"Jacqueline","family":"Kruse","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery, University Hospital Bonn, 53127 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Silaschi","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, University Hospital Bonn, 53127 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Celik","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, University Hospital Bonn, 53127 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9763-7304","authenticated-orcid":false,"given":"Marwan","family":"Hamiko","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, University Hospital Bonn, 53127 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eissa","family":"Alaj","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, University Hospital Bonn, 53127 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossien","family":"Alirezaei","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, University Hospital Bonn, 53127 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6836-8536","authenticated-orcid":false,"given":"Atsushi","family":"Sugiura","sequence":"additional","affiliation":[{"name":"Department of Medicine II, Heart Center Bonn, University Hospital Bonn, 53127 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enzo","family":"L\u00fcsebrink","sequence":"additional","affiliation":[{"name":"Department of Medicine II, Heart Center Bonn, University Hospital Bonn, 53127 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Zimmer","sequence":"additional","affiliation":[{"name":"Department of Medicine II, Heart Center Bonn, University Hospital Bonn, 53127 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhad","family":"Bakhtiary","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, University Hospital Bonn, 53127 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.jcin.2022.12.009","article-title":"Vascular access in patients with peripheral arterial disease undergoing TAVR: The Hostile registry","volume":"16","author":"Palmerini","year":"2023","journal-title":"J. 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Res."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/2\/843\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T16:30:57Z","timestamp":1769445057000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/2\/843"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,20]]},"references-count":13,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,1]]}},"alternative-id":["jcm15020843"],"URL":"https:\/\/doi.org\/10.3390\/jcm15020843","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,20]]}}}