{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:19:48Z","timestamp":1790619588176,"version":"4.1.0"},"reference-count":20,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: In internal medicine, the management of type 2 diabetes mellitus (T2DM) is challenged by multimorbidity and polypharmacy. The fixed-dose combination of sitagliptin and extended-release metformin (SITA\/MET ER) is a valuable option for frail and comorbid patients. Methods: This multicenter, retrospective, observational study involved five Italian Internal Medicine units. Consecutive patients with T2DM who initiated SITA\/MET ER were included. Demographic, clinical, and laboratory data were collected at baseline (T0) and at follow-up (T1, 3\u20134 months). The primary endpoint was change in HbA1c; secondary endpoints included fasting plasma glucose (FPG), treatment adherence, adverse events, and modifications in concomitant antidiabetic therapies. Results: A total of 292 patients (mean age 70.8 \u00b1 10.6 years; 43% female) were analyzed. At baseline, mean HbA1c was 7.4 \u00b1 1.0% and FPG 150.2 \u00b1 42.5 mg\/dL, with significant reductions observed at follow-up (HbA1c 7.0 \u00b1 0.8%, FPG 136.8 \u00b1 29.6 mg\/dL; both p &lt; 0.05). SITA\/MET ER was predominantly prescribed to patients with a complex clinical profile, as reflected by the high prevalence of microvascular (37%) and macrovascular (42%) complications. The use of sulfonylureas decreased from 11% to 3% (p &lt; 0.001), while SGLT2 inhibitor and insulin use remained stable. Treatment adherence to SITA\/MET ER was excellent, with full compliance reported and no adverse events recorded. Conclusions: In this real-world internal medicine study, SITA\/MET ER improved glycemic control and was well tolerated among patients with complex clinical profiles. These findings support the role of SITA\/MET ER as a flexible and practical therapeutic choice in this setting.<\/jats:p>","DOI":"10.3390\/jcm15030927","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T09:21:40Z","timestamp":1769505700000},"page":"927","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Patterns and Clinical Outcomes of Sitagliptin\/Metformin Extended-Release in Internal Medicine: A Real-World Multicenter Italian Study"],"prefix":"10.3390","volume":"15","author":[{"given":"Mariarosaria","family":"De Luca","sequence":"first","affiliation":[{"name":"Department of Translational Medical Sciences, University of Naples \u201cFederico II\u201d, Via Pansini n.5, 80127 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Arcopinto","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences, University of Naples \u201cFederico II\u201d, Via Pansini n.5, 80127 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6036-927X","authenticated-orcid":false,"given":"Giosiana","family":"Bosco","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy"},{"name":"Department of Medicine and Surgery, \u201cKore\u201d University of Enna, 94100 Enna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1980-5728","authenticated-orcid":false,"given":"Sebastiano","family":"Cicco","sequence":"additional","affiliation":[{"name":"Unit of Internal Medicine \u201cGuido Baccelli\u201d and Arterial Hypertension \u201cAnna Maria Pirrelli\u201d, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari Aldo Moro, University Hospital Policlinico Di Bari, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2746-8104","authenticated-orcid":false,"given":"Francesco","family":"Di Giacomo Barbagallo","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy"},{"name":"Department of Medicine and Surgery, \u201cKore\u201d University of Enna, 94100 Enna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Giacinti","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Perugia, 06123 Terni, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7832-357X","authenticated-orcid":false,"given":"Marialuisa Sveva","family":"Marozzi","sequence":"additional","affiliation":[{"name":"Unit of Internal Medicine \u201cGuido Baccelli\u201d and Arterial Hypertension \u201cAnna Maria Pirrelli\u201d, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari Aldo Moro, University Hospital Policlinico Di Bari, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maristella Salvatora","family":"Masala","sequence":"additional","affiliation":[{"name":"Metabolic Diseases and Diabetology, Health District of Sassari, 07100 Sassari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Pinna","sequence":"additional","affiliation":[{"name":"Metabolic Diseases and Diabetology, Health District of Sassari, 07100 Sassari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0180-859X","authenticated-orcid":false,"given":"Giacomo","family":"Pucci","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Perugia, 06123 Terni, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Salzano","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences, University of Naples \u201cFederico II\u201d, Via Pansini n.5, 80127 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7023-3649","authenticated-orcid":false,"given":"Roberto","family":"Scicali","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto Maria","family":"Marra","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences, University of Naples \u201cFederico II\u201d, Via Pansini n.5, 80127 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Cittadini","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences, University of Naples \u201cFederico II\u201d, Via Pansini n.5, 80127 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00125-021-05585-2","article-title":"Interpreting global trends in type 2 diabetes complications and mortality","volume":"65","author":"Ali","year":"2022","journal-title":"Diabetologia"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s11892-024-01545-3","article-title":"Review Article\u2014Diabetes Technology in the Hospital: An Update","volume":"24","author":"Visser","year":"2024","journal-title":"Curr. 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