{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T23:17:33Z","timestamp":1787872653492,"version":"build-2784847793"},"reference-count":47,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Nailfold videocapillaroscopy (NVC) is a non-invasive method for visualizing systemic micro-circulation, primarily used in rheumatology. Many ocular diseases (e.g., glaucoma, diabetic retinopathy (DR), and central serous chorioretinopathy (CSC)) involve microvascular disturbances. Since microangiopathies are often systemic, NVC findings may reflect ocular pathology. This narrative review aimed to summarize current evidence linking NVC alterations with retinal, choroidal, and optic nerve diseases. Methods: A literature search of PubMed, Scopus, and Web of Science (2000\u20132025) was conducted using the keywords \u201cnailfold videocapillaroscopy,\u201d \u201cocular diseases,\u201d \u201cretinopathy,\u201d and \u201cglaucoma\u201d. Results: Most available studies were cross-sectional and exploratory. In glaucoma, NVC abnormalities suggesting systemic hypoperfusion (reduced capillary density, avascular areas, tortuosity, and microhemorrhages) were frequently reported. CSC was associated with capillary dilation patterns (megacapillaries and aneurysmal dilations), supporting a congestive rather than ischemic microvascular profile. In DR, NVC abnormalities (reduced density and neoangiogenesis) correlated with DR severity. Associations were also found for AMD and idiopathic macular telangiectasia type 2 (MacTel2, also known as IMT). However, only a limited number of prospective studies assessed diagnostic performance, and data on sensitivity, specificity, or ROC-based validation remain scarce. Conclusions: Current evidence suggests that NVC reflects systemic microvascular alterations associated with several ocular diseases. While NVC shows potential as an adjunctive tool for risk assessment and phenotyping, its diagnostic validity has not yet been established. Limitations include the predominantly observational nature of the studies, heterogeneity of methodologies, and the lack of standardized diagnostic thresholds. Prospective trials integrating NVC with ocular imaging modalities, such as OCT angiography, are needed to determine its clinical utility.<\/jats:p>","DOI":"10.3390\/jcm15030931","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T09:21:40Z","timestamp":1769505700000},"page":"931","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Role of Nailfold Videocapillaroscopy (NVC) in Evaluating Ocular Diseases: Insights into Retinal, Choroidal, and Optic Nerve Pathologies"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7607-7843","authenticated-orcid":false,"given":"Ma\u0142gorzata","family":"Latalska","sequence":"first","affiliation":[{"name":"Department of General and Pediatric Ophthalmology, Medical University of Lublin, 20-079 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0466-1343","authenticated-orcid":false,"given":"Magdalena","family":"W\u00f3jciak","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Medical University of Lublin, Chod\u017aki 4a, 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Skalska-Kami\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Medical University of Lublin, Chod\u017aki 4a, 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4413-3748","authenticated-orcid":false,"given":"S\u0142awomir","family":"Dresler","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Medical University of Lublin, Chod\u017aki 4a, 20-093 Lublin, Poland"},{"name":"Department of Plant Physiology and Biophysics, Institute of Biological Sciences, Faculty of Biology and Biotechnology, Maria Curie-Sk\u0142odowska University, 19 Akademicka St., 20-033 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.berh.2008.09.001","article-title":"Capillaroscopy","volume":"22","author":"Cutolo","year":"2008","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Komai, M., Takeno, D., Fujii, C., Nakano, J., Ohsaki, Y., and Shirakawa, H. (2024). Nailfold Capillaroscopy: A Comprehensive Review on Its Usefulness in Both Clinical Diagnosis and Improving Unhealthy Dietary Lifestyles. Nutrients, 16.","DOI":"10.20944\/preprints202404.0078.v1"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"102458","DOI":"10.1016\/j.autrev.2020.102458","article-title":"Standardisation of Nailfold Capillaroscopy for the Assessment of Patients with Raynaud\u2019s Phenomenon and Systemic Sclerosis","volume":"19","author":"Smith","year":"2020","journal-title":"Autoimmun. Rev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"6","DOI":"10.2152\/jmi.68.6","article-title":"Nailfold Capillaroscopy: A Comprehensive Review on Common Findings and Clinical Usefulness in Non-Rheumatic Disease","volume":"68","author":"Mansueto","year":"2021","journal-title":"J. Med. Investig."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1097\/HJH.0000000000003873","article-title":"Nailfold Videocapillaroscopy as a Non-Invasive Tool for the Assessment of Peripheral Microangiopathy in Cardiovascular Diseases","volume":"43","author":"Baroutidou","year":"2025","journal-title":"J. Hypertens."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"104036","DOI":"10.1016\/j.mvr.2020.104036","article-title":"Nailfold Capillaroscopy in Common Non-Rheumatic Conditions: A Systematic Review and Applications for Clinical Practice","volume":"131","author":"Ciaffi","year":"2020","journal-title":"Microvasc. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1097\/IJG.0000000000001678","article-title":"Association of Nailfold Capillary Abnormalities with Primary Open-Angle Glaucoma and Glaucomatous Visual Field Loss","volume":"30","author":"Goh","year":"2021","journal-title":"J. Glaucoma"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1111\/jdi.13444","article-title":"Association of Crossing Capillaries in the Finger Nailfold with Diabetic Retinopathy in Type 2 Diabetes Mellitus","volume":"12","author":"Shikama","year":"2021","journal-title":"J. Diabetes Investig."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1007\/s11845-019-02109-1","article-title":"Is Age-Related Macular Degeneration a Local Manifestation of Systemic Disorder? Changes in Nailfold Capillaries at Age-Related Macular Degeneration","volume":"189","author":"Ayan","year":"2020","journal-title":"Ir. J. Med. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Abbas, Q., Jeong, W., and Lee, S.W. (2025). Explainable AI in Clinical Decision Support Systems: A Meta-Analysis of Methods, Applications, and Usability Challenges. Healthcare, 13.","DOI":"10.3390\/healthcare13172154"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Xu, F., Li, Z., Yang, X., Gao, Y., Li, Z., Li, G., Wang, S., Ning, X., and Li, J. (2023). Assessment of Choroidal Structural Changes in Patients with Pre- and Early-Stage Clinical Diabetic Retinopathy Using Wide-Field SS-OCTA. Front. Endocrinol., 13.","DOI":"10.3389\/fendo.2022.1036625"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Paczwa, K., Rerych, M., Romanowska-Pr\u00f3chnicka, K., R\u00f3\u017cycki, R., and Go\u0142\u0119biewska, J. (2024). Ocular Manifestation in Systemic Sclerosis\u2014A Literature Review. Life, 14.","DOI":"10.3390\/life14050627"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"198","DOI":"10.4078\/jrd.2024.0124","article-title":"The Correlation between Retinal Microvascular Changes by Optical Coherence Tomography Angiography and Nailfold Capillaroscopic Findings in Patients with Systemic Sclerosis","volume":"32","author":"Elsayed","year":"2025","journal-title":"J. Rheum. Dis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"100973","DOI":"10.1016\/j.preteyeres.2021.100973","article-title":"Venous Overload Choroidopathy: A Hypothetical Framework for Central Serous Chorioretinopathy and Allied Disorders","volume":"86","author":"Spaide","year":"2022","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"7021","DOI":"10.1167\/iovs.15-17860","article-title":"Nailfold Capillary Abnormalities in Primary Open-Angle Glaucoma: A Multisite Study","volume":"56","author":"Pasquale","year":"2015","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1080\/02713683.2018.1438632","article-title":"Results of Nailfold Capillaroscopy in Patients with Normal-Tension Glaucoma","volume":"43","author":"Krasowska","year":"2018","journal-title":"Curr. Eye Res."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Takahashi, N., Kiyota, N., Kunikata, H., Yamazaki, M., Nishimura, T., Shiga, Y., Aoyagi, H., Shidomi, M., Tsuda, T., and Ohtsuka, T. (2023). Vasoreactivity of the Optic Nerve Head, Nailfold, and Facial Skin in Response to Cold Provocation in Normal-Tension Glaucoma Patients. BMC Ophthalmol., 23.","DOI":"10.1186\/s12886-023-03059-0"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1136\/bjophthalmol-2018-311846","article-title":"Resting Nailfold Capillary Blood Flow in Primary Open-Angle Glaucoma","volume":"103","author":"Cousins","year":"2019","journal-title":"Br. J. Ophthalmol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.mvr.2013.07.001","article-title":"Nailfold Capillary Patterns in Healthy Subjects: A Real Issue in Capillaroscopy","volume":"90","author":"Ingegnoli","year":"2013","journal-title":"Microvasc. Res."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Tian, J., Xie, Y., Li, M., Oatts, J., Han, Y., Yang, Y., Shi, Y., Sun, Y., Sang, J., and Cao, K. (2020). The Relationship Between Nailfold Microcirculation and Retinal Microcirculation in Healthy Subjects. Front. Physiol., 11.","DOI":"10.3389\/fphys.2020.00880"},{"key":"ref_21","first-page":"410","article-title":"[Nailfold capillaroscopy. Comparison of 100 subjects over 65 years of age and of 100 young adults]","volume":"15","author":"Piette","year":"1990","journal-title":"J. Mal. Vasc."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/eye.2016.312","article-title":"Nailfold Capillary Morphology in Exfoliation Syndrome","volume":"31","author":"Cousins","year":"2017","journal-title":"Eye"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"\u0141ukasik, U., Bartosi\u0144ska, J., Kosior-Jarecka, E., Wr\u00f3bel-Dudzi\u0144ska, D., Krasowska, D., and \u017barnowski, T. (2023). Results of Nailfold Videocapillaroscopy in Patients with Pseudoexfoliative Glaucoma. Life, 13.","DOI":"10.3390\/life13040967"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1167\/tvst.10.7.13","article-title":"Paired Optic Nerve Microvasculature and Nailfold Capillary Measurements in Primary Open-Angle Glaucoma","volume":"10","author":"Shoji","year":"2021","journal-title":"Trans. Vis. Sci. Tech."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1001\/jamaophthalmol.2019.0434","article-title":"Nailfold Capillaroscopy of Resting Peripheral Blood Flow in Exfoliation Glaucoma and Primary Open-Angle Glaucoma","volume":"137","author":"Philip","year":"2019","journal-title":"JAMA Ophthalmol."},{"key":"ref_26","first-page":"251","article-title":"Is There an Association between Glaucoma and Capillaroscopy in Patients with Systemic Sclerosis?","volume":"38","author":"Gomes","year":"2017","journal-title":"Int. Ophthalmol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"382","DOI":"10.4103\/idoj.IDOJ_264_19","article-title":"Nailfold Capillaroscopy and Retinal Findings in Patients with Systemic Sclerosis: Is There an Association?","volume":"11","author":"Jakhar","year":"2020","journal-title":"Indian Dermatol. Online J."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1177\/2397198319833486","article-title":"Nailfold Capillaroscopy in Systemic Sclerosis\u2014State of the Art: The Evolving Knowledge about Capillaroscopic Abnormalities in Systemic Sclerosis","volume":"4","author":"Lambova","year":"2019","journal-title":"J. Scleroderma Relat. Disord."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Minopoulou, I., Theodorakopoulou, M., Boutou, A., Arvanitaki, A., Pitsiou, G., Doumas, M., Sarafidis, P., and Dimitroulas, T. (2021). Nailfold Capillaroscopy in Systemic Sclerosis Patients with and without Pulmonary Arterial Hypertension: A Systematic Review and Meta-Analysis. J. Clin. Med., 10.","DOI":"10.3390\/jcm10071528"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1007\/s00417-016-3322-1","article-title":"Evaluation of Nailfold Videocapillaroscopy in Central Serous Chorioretinopathy","volume":"254","author":"Erol","year":"2016","journal-title":"Graefes. Arch. Clin. Exp. Ophthalmol."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Latalska, M., Bartosi\u0144ska, J., Kosior-Jarecka, E., Krasowska, D., and Mackiewicz, J. (2020). Nailfold Videocapillaroscopy in Patients with Central Serous Chorioretinopathy and Its Relationship to Morphological and Functional Findings. J. Clin. Med., 9.","DOI":"10.3390\/jcm9123891"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Latalska, M., Bartosi\u0144ska, J., Dresler, S., Toro, M.D., Krasowska, D., and Rejdak, R. (2023). Comparison of Nailfold Videocapillaroscopy with Retinal and Choroidal Vascular Parameters in Patients with Central Serous Chorioretinopathy. J. Clin. Med., 12.","DOI":"10.3390\/jcm12144817"},{"key":"ref_33","first-page":"146","article-title":"The Evaluation of Nailfold Videocapillaroscopy Findings in Type 2 Diabetic Patients with and without Diabetic Retinopathy","volume":"6","author":"Bakirci","year":"2018","journal-title":"North. Clin. Istanb."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s43162-025-00436-7","article-title":"Utility of Nailfold Capillaroscopy in the Assessment of Microvascular Alterations in Diabetes Mellitus and Its Correlation with Diabetic Retinopathy: A Cross-Sectional Comparative Study","volume":"37","author":"Prakashey","year":"2025","journal-title":"Egypt. J. Intern. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"5075","DOI":"10.1007\/s10067-025-07720-5","article-title":"Non-Rheumatologic Indications of Nail Fold Capillaroscopy: Findings in Type 2 Diabetic Patients with or without Diabetic Retinopathy: A Cross-Sectional Study","volume":"44","author":"Elghany","year":"2025","journal-title":"Clin. Rheumatol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"7592402","DOI":"10.1155\/2016\/7592402","article-title":"Assessment of the Relationship between Diabetic Retinopathy and Nailfold Capillaries in Type 2 Diabetics with a Noninvasive Method: Nailfold Videocapillaroscopy","volume":"2016","author":"Uyar","year":"2016","journal-title":"J. Diabetes Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"27","DOI":"10.5114\/reum.2021.103436","article-title":"Prevalence of Retinal Changes in Patients with Systemic Sclerosis: The Association between Retinal Vascular Changes and Nailfold Capillaroscopic Findings","volume":"59","author":"Shenavandeh","year":"2021","journal-title":"Reumatologia"},{"key":"ref_38","first-page":"1742","article-title":"Can Nailfold Capillaroscopy Findings Be a Marker for Uveitis in Beh\u00e7et\u2019s Syndrome?","volume":"43","author":"Zontul","year":"2024","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"S148","DOI":"10.4103\/IJO.IJO_1731_23","article-title":"Proximal Nailfold Videocapillaroscopy Findings of Patients with Idiopathic Macular Telangiectasia Type 2","volume":"72","author":"Gedik","year":"2024","journal-title":"Indian J. Ophthalmol."},{"key":"ref_40","first-page":"824319","article-title":"Nailfold Capillary Hemorrhages: Microvascular Risk Factors for Primary Open-Angle Glaucoma","volume":"2020","author":"Pfahler","year":"2020","journal-title":"J. Ophthalmol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e882","DOI":"10.1111\/aos.14416","article-title":"Relationship between Nailfold Capillary Morphology and Retinal Thickness and Retinal Vessel Density in Primary Open-angle and Angle-closure Glaucoma","volume":"98","author":"Rong","year":"2020","journal-title":"Acta Ophthalmol."},{"key":"ref_42","first-page":"1","article-title":"Nail Folds Capillaries Abnormalities Associated with Type 2 Diabetes Mellitus Progression and Correlation with Diabetic Retinopathy","volume":"15","author":"Hafez","year":"2022","journal-title":"Clin. Med. Insights Endocrinol. Diabetes"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1080\/02713683.2018.1496265","article-title":"A Cross-Sectional Observational Study of Nailfold Capillary Morphology in Uveitis","volume":"43","author":"Chen","year":"2018","journal-title":"Curr. Eye Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s12969-023-00896-7","article-title":"Involvement of the Systemic Microcirculation in Pediatric Uveitis","volume":"21","author":"Kouwenberg","year":"2023","journal-title":"Pediatr. Rheumatol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"3855","DOI":"10.1007\/s10067-024-07183-0","article-title":"Nailfold Capillaroscopic Assessment in Pediatric Patients with Autoimmune Uveitis: A Case\u2013Control Study","volume":"43","author":"Abdelrahman","year":"2024","journal-title":"Clin. Rheumatol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"104822","DOI":"10.1016\/j.mvr.2025.104822","article-title":"Nailfold Capillary Morphology Changes in Patients with Retinal Vein Occlusion","volume":"160","author":"Zhang","year":"2025","journal-title":"Microvasc. Res."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Abbas, S.R., Seol, H., Abbas, Z., and Lee, S.W. (2025). Exploring the Role of Artificial Intelligence in Smart Healthcare: A Capability and Function-Oriented Review. 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