{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:51:04Z","timestamp":1787028664514,"version":"build-2736575974"},"reference-count":14,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T00:00:00Z","timestamp":1769212800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Pachydermoperiostosis, also known as primary hypertrophic osteoarthropathy or Touraine\u2013Solente\u2013Gol\u00e9 syndrome, is a rare genetic disorder that represents a small fraction of hypertrophic osteoarthropathy cases. It typically begins during adolescence, affects males more frequently and follows either an autosomal dominant or recessive inheritance pattern. The disease is characterized by the triad of pachydermia, periostosis and digital clubbing, often accompanied by hyperhidrosis, seborrhea, cutis verticis gyrata and joint effusions. Although articular involvement is usually non-erosive, the disorder may mimic inflammatory arthritis and lead to diagnostic delays. Recognition of the major and minor diagnostic criteria is crucial to distinguish PDP from secondary forms related to pulmonary, cardiac or neoplastic disease.<\/jats:p>","DOI":"10.3390\/jcm15030956","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T09:21:40Z","timestamp":1769505700000},"page":"956","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["From Juvenile Idiopathic Arthritis to Pachydermoperiostosis: A Journey to an Unexpected Rare Diagnosis"],"prefix":"10.3390","volume":"15","author":[{"given":"Marilena","family":"Stoian","sequence":"first","affiliation":[{"name":"Internal Medicine and Rheumatology Department, Dr I. Cantacuzino Hospital, Carol Davila University of Medicine and Pharmacy, 020475 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Maria","family":"Dumitrescu","sequence":"additional","affiliation":[{"name":"Dclinic, 013738 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Ciofu","sequence":"additional","affiliation":[{"name":"Internal Medicine and Rheumatology Department, Dr I. Cantacuzino Hospital, Carol Davila University of Medicine and Pharmacy, 020475 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogdan","family":"Gavrila","sequence":"additional","affiliation":[{"name":"Internal Medicine and Rheumatology Department, Dr I. Cantacuzino Hospital, Carol Davila University of Medicine and Pharmacy, 020475 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Lu, Q., Xu, Y., Zhang, Z., Li, S., and Zhang, Z. (2023). Primary hypertrophic osteoarthropathy: Genetics, clinical features and management. Front. Endocrinol., 14.","DOI":"10.3389\/fendo.2023.1235040"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"ziaf026","DOI":"10.1093\/jbmrpl\/ziaf026","article-title":"Primary hypertrophic osteoarthropathy: Phenotypic variability and penetrance rate in heterozygotes for SLCO2A1 variants","volume":"9","author":"Arcanjo","year":"2025","journal-title":"JBMR Plus"},{"key":"ref_3","unstructured":"Chakraborty, R.K., and Sharma, S. (2026, January 20). Secondary Hypertrophic Osteoarthropathy, StatPearls [Internet], Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK513342."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1002\/jbmr.4310","article-title":"Monoallelic mutations in SLCO2A1 cause autosomal dominant primary hypertrophic osteoarthropathy","volume":"36","author":"Xu","year":"2021","journal-title":"J. Bone Miner. Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1002\/ccr3.1971","article-title":"Complete primary pachydermoperiostosis: A case report and review of the literature","volume":"7","author":"Salah","year":"2019","journal-title":"Clin. Case Rep."},{"key":"ref_6","first-page":"e92731","article-title":"Pachydermoperiostosis associated with a rare SLCO2A1 mutation: A case report and literature review","volume":"17","author":"Mohammad","year":"2025","journal-title":"Cureus"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Li, J., Jia, S., Guo, J., Xie, W., Ma, Y., Gao, X., and Gao, M. (2025). Primary hypertrophic osteoarthropathy caused by HPGD variants: A case report and literature review. BMC Pediatr., 25.","DOI":"10.1186\/s12887-025-05590-z"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1111\/j.1399-0004.2005.00533.x","article-title":"Pachydermoperiostosis: An update","volume":"68","author":"Castori","year":"2005","journal-title":"Clin. Genet."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"280","DOI":"10.5114\/ceji.2022.120171","article-title":"Primary hypertrophic osteoarthropathy\u2013A rare cause of pain and arthritis in children. Description of 5 cases","volume":"47","author":"Gazda","year":"2022","journal-title":"Cent. Eur. J. Immunol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"98","DOI":"10.3390\/rheumato3010008","article-title":"Pachydermoperiostosis Mimicking Inflammatory Arthritis: Case Description and Narrative Review","volume":"3","author":"Kamruzzaman","year":"2023","journal-title":"Rheumato"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jcot.2014.02.003","article-title":"Pachydermoperiostosis\u2014A case report of complete form and literature review","volume":"5","author":"Supradeeptha","year":"2014","journal-title":"J. Clin. Orthop. Trauma"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e8865","DOI":"10.1097\/MD.0000000000008865","article-title":"Successful treatment of pachydermoperiostosis with etoricoxib, aescin and arthroscopic synovectomy: Two case reports","volume":"96","author":"Zhang","year":"2017","journal-title":"Medicine"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1186\/s13023-025-03722-3","article-title":"Distinct clinical features of three subtypes in 533 patients with primary hypertrophic osteoarthropathy","volume":"20","author":"Cai","year":"2025","journal-title":"Orphanet J. Rare Dis."},{"key":"ref_14","first-page":"67","article-title":"The medical and surgical treatment of finger clubbing and hypertrophic osteoarthropathy. A blind study with colchicine and a surgical approach to finger clubbing reduction","volume":"10","author":"Ceruso","year":"1992","journal-title":"Clin. Exp. Rheumatol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/3\/956\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T09:38:07Z","timestamp":1769506687000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/3\/956"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,24]]},"references-count":14,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,2]]}},"alternative-id":["jcm15030956"],"URL":"https:\/\/doi.org\/10.3390\/jcm15030956","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,24]]}}}