{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:04:19Z","timestamp":1791259459055,"version":"4.1.0"},"reference-count":21,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Heart failure (HF) remains a major cause of hospitalizations in the United States (US). Respiratory syncytial virus (RSV) has been associated with HF exacerbations. We compared in-hospital outcomes and healthcare utilization among US HF hospitalizations with and without RSV. Methods: Using the Nationwide Readmissions Database (2016\u20132022), we propensity-matched HF hospitalizations with a secondary diagnosis of RSV (HF-RSV) 1:1 to those without RSV (HF-noRSV). Multivariable logistic and Poisson regression models were used to assess associations between RSV and outcomes. The primary outcome was in-hospital mortality; secondary outcomes included adverse events, length of stay (LOS), hospitalization costs, and 30-day readmissions. Results: Among 11,158,836 HF hospitalizations, 32,419 (0.29%) had RSV. Compared with matched HF-noRSV hospitalizations, HF-RSV was associated with higher odds of in-hospital mortality (adjusted odds ratio [aOR] 1.12; 95% CI 1.04\u20131.20), septic shock (aOR 1.40; 95% CI 1.29\u20131.52), acute respiratory failure (aOR 3.43; 95% CI 3.32\u20133.55), and noninvasive mechanical ventilation (aOR 2.15; 95% CI 2.04\u20132.26). HF-RSV had lower odds of cardiogenic shock (aOR 0.82; 95% CI 0.73\u20130.92), ventricular tachycardia\/fibrillation (aOR 0.73; 95% CI 0.68\u20130.78), ischemic stroke (aOR 0.31; 95% CI 0.27\u20130.36), transient ischemic attack (aOR 0.33; 95% CI 0.25\u20130.44), and 30-day readmissions (aOR 0.54; 95% CI 0.46\u20130.56). HF-RSV hospitalizations had higher costs (adjusted coefficient 0.02; 95% CI 0.01\u20130.02) and longer LOS (adjusted coefficient 0.14; 95% CI 0.13\u20130.14). Conclusions: Among US HF hospitalizations, RSV was associated with higher mortality and respiratory-related complications and increased healthcare resource utilization.<\/jats:p>","DOI":"10.3390\/jcm15030990","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T09:21:40Z","timestamp":1769505700000},"page":"990","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of Heart Failure Hospitalizations with and Without Respiratory Syncytial Virus: A Nationwide Administrative Data Analysis"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6330-5042","authenticated-orcid":false,"given":"Nikita","family":"Patil","sequence":"first","affiliation":[{"name":"Hospitalist Department, Cape Fear Valley Health, Fayetteville, NC 28304, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3606-6370","authenticated-orcid":false,"given":"Shubhadarshini","family":"Pawar","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Smidt Heart Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshmi","family":"Menon","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7548-2894","authenticated-orcid":false,"given":"Prasad","family":"Jogu","sequence":"additional","affiliation":[{"name":"Hospitalist Department, Sutter Roseville Medical Center, Roseville, CA 95661, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5507-9712","authenticated-orcid":false,"given":"Sagar","family":"Bathija","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Lowell General Hospital, Tufts Medicine, Lowell, MA 01854, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahita","family":"Bellamkonda","sequence":"additional","affiliation":[{"name":"Department of Hospital Medicine, Oklahoma University Health Science Center, Oklahoma City, OK 73104, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2670-5298","authenticated-orcid":false,"given":"Muskan","family":"Joshi","sequence":"additional","affiliation":[{"name":"International Faculty of Medicine, Tbilisi State Medical University, Tbilisi 0186, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swathi","family":"Nimmala","sequence":"additional","affiliation":[{"name":"Hospitalist Department, Cape Fear Valley Health, Fayetteville, NC 28304, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun R.","family":"Sridhar","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Pulse Heart Institute, Multicare Health System, Tacoma, WA 98402, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"ofac300","DOI":"10.1093\/ofid\/ofac300","article-title":"Rates of Medically Attended RSV Among US Adults: A Systematic Review and Meta-analysis","volume":"9","author":"McLaughlin","year":"2022","journal-title":"Open Forum Infect. 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