{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T02:35:20Z","timestamp":1783996520256,"version":"3.55.0"},"reference-count":28,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Blood Flow Restriction training has been suggested as a method to enhance strength and neuromuscular adaptations at low exercise intensities. Early reports indicate potential effects on pain perception, myofascial stiffness, and flexibility; however, the evidence remains inconsistent. Method: Twenty-two healthy adults participated in a randomized, within-participant, contralateral-controlled design, performing 5 min of treadmill walking (4\u20135 km\/h) with and without blood flow restriction at 70% arterial occlusion pressure. Pressure pain threshold, hip range of motion, and hamstring stiffness were measured before and after the intervention. Adverse effects were recorded. Results: Changes in pain threshold, range of motion, and myofascial stiffness were similar between conditions. The pressure pain threshold decreased slightly in both conditions, regardless of BFR, while range of motion and stiffness remained unchanged. Mild, short-lasting sensations (cuff pressure, erythema, tingling) were reported, with no adverse events. Conclusions: A single short session of low-intensity BFR walking did not change pain sensitivity, flexibility, or myofascial stiffness in healthy adults. The protocol was well tolerated. Repeated or longer interventions may be needed to see measurable effects.<\/jats:p>","DOI":"10.3390\/jcm15031052","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T15:04:46Z","timestamp":1769612686000},"page":"1052","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Acute Effects of Low-Intensity Blood-Flow-Restricted Walking on Pain Sensitivity, Joint Range of Motion, and Myofascial Stiffness in Healthy Adults"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1225-0475","authenticated-orcid":false,"given":"Robert","family":"Schleip","sequence":"first","affiliation":[{"name":"Department for Medical Professions, Diploma University of Applied Sciences, 37242 Bad Sooden-Allendorf, Germany"},{"name":"Department of Conservative and Rehabilitative Orthopedics, TUM School of Medicine & Health, Technical University of Munich, 80809 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliane","family":"Herzer Santana","sequence":"additional","affiliation":[{"name":"Department for Medical Professions, Diploma University of Applied Sciences, 37242 Bad Sooden-Allendorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2101-3156","authenticated-orcid":false,"given":"Christoph","family":"Egner","sequence":"additional","affiliation":[{"name":"Department for Medical Professions, Diploma University of Applied Sciences, 37242 Bad Sooden-Allendorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8757-2551","authenticated-orcid":false,"given":"Andreas","family":"Brandl","sequence":"additional","affiliation":[{"name":"Department for Medical Professions, Diploma University of Applied Sciences, 37242 Bad Sooden-Allendorf, Germany"},{"name":"Department of Conservative and Rehabilitative Orthopedics, TUM School of Medicine & Health, Technical University of Munich, 80809 Munich, Germany"},{"name":"Triagon Academy, MRS 1331 Marsa, Malta"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2460-5197","authenticated-orcid":false,"given":"Lea","family":"Overmann","sequence":"additional","affiliation":[{"name":"Private Clinic Overmann, 59229 Ahlen, Germany"},{"name":"Fascia Research Project, 80799 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Patterson, S.D., Hughes, L., Warmington, S., Burr, J., Scott, B.R., and Owens, J. (2019). Blood Flow Restriction Exercise: Considerations of Methodology, Application, and Safety. Front. Physiol., 10.","DOI":"10.3389\/fphys.2019.00533"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e4697","DOI":"10.7717\/peerj.4697","article-title":"Influence and reliability of lower-limb arterial occlusion pressure at different body positions","volume":"6","author":"Hughes","year":"2018","journal-title":"PeerJ"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1007\/s00421-011-2167-x","article-title":"Low intensity blood flow restriction training: A meta-analysis","volume":"112","author":"Loenneke","year":"2012","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s40279-014-0264-9","article-title":"A review on the mechanisms of blood-flow restriction resistance training-induced muscle hypertrophy","volume":"45","author":"Pearson","year":"2015","journal-title":"Sports Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1519\/JSC.0000000000004397","article-title":"Effect of increased pressure pain threshold on resistance exercise performance with blood flow restriction","volume":"37","author":"Kataoka","year":"2023","journal-title":"J. Strength Cond. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1152\/japplphysiol.00768.2019","article-title":"The effect of blood flow restriction exercise on exercise-induced hypoalgesia and endogenous opioid and endocannabinoid mechanisms of pain modulation","volume":"128","author":"Hughes","year":"2020","journal-title":"J. Appl. Physiol."},{"key":"ref_7","first-page":"34","article-title":"Effects of low-intensity walk training with restricted leg blood flow on muscle strength and aerobic capacity in older adults","volume":"33","author":"Abe","year":"2010","journal-title":"J. Geriatr. Phys. Ther."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3806\/ijktr.7.1","article-title":"Key considerations when conducting KAATSU training","volume":"7","author":"Nakajima","year":"2011","journal-title":"Int. J. KAATSU Train. Res."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Nascimento, D.C., Rolnick, N., Neto, I.V.S., Severin, R., and Beal, F.L.R. (2022). A useful blood flow restriction training risk stratification for exercise and rehabilitation. Front. Physiol., 13.","DOI":"10.3389\/fphys.2022.808622"},{"key":"ref_10","first-page":"3","article-title":"Safety considerations with blood flow restricted resistance training","volume":"6","author":"Kacin","year":"2016","journal-title":"Ann. Kinesiol."},{"key":"ref_11","unstructured":"Urbaniak, G.C., and Plous, S. (2026, January 03). Research Randomizer (Version 4.0). Available online: https:\/\/www.randomizer.org\/."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1038\/s41598-023-27742-w","article-title":"Assessing reliability and validity of different stiffness measurement tools on a multi-layered phantom tissue model","volume":"13","author":"Bartsch","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Koch, V., and Wilke, J. (2022). Reliability of a new indentometer device for measuring myofascial tissue stiffness. J. Clin. Med., 11.","DOI":"10.3390\/jcm11175194"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.26603\/001c.90865","article-title":"Reliability of the EasyAngle\u00ae for assessing hip range of motion in healthy children","volume":"19","author":"Duffy","year":"2024","journal-title":"Int. J. Sports Phys. Ther."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Luedtke, K., Schoettker-K\u00f6niger, T., Hall, T., Reimer, C., Grassold, M., and Hasselhoff-Styhler, P. (2020). Concurrent validity and reliability of a digital goniometer in the cervical flexion-rotation test. BMC Musculoskelet. Disord., 21.","DOI":"10.1186\/s12891-020-03525-6"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1519\/JSC.0000000000003628","article-title":"Determining the arterial occlusion pressure for blood flow restriction: Pulse oximeter as a new method compared with a handheld Doppler","volume":"36","author":"Pessoa","year":"2022","journal-title":"J. Strength Cond. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1123\/ijspp.2019-0043","article-title":"Blood-flow-restriction training: Validity of pulse oximetry to assess arterial occlusion pressure","volume":"14","author":"Zeng","year":"2019","journal-title":"Int. J. Sports Physiol. Perform."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Das, A., and Paton, B. (2022). Is there a minimum effective dose for vascular occlusion during blood flow restriction training?. Front. Physiol., 13.","DOI":"10.3389\/fphys.2022.838115"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s00421-017-3770-2","article-title":"Body position influences arterial occlusion pressure: Implications for the standardization of pressure during blood flow restricted exercise","volume":"118","author":"Sieljacks","year":"2018","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Franz, A., Ji, S., Bittersohl, B., Zilkens, C., and Behringer, M. (2022). Impact of a six-week prehabilitation with blood-flow restriction training in knee arthroplasty patients. Front. Physiol., 13.","DOI":"10.3389\/fphys.2022.881484"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Karanasios, S., Lignos, I., Kouvaras, K., Moutzouri, M., and Gioftsos, G. (2023). Low-Intensity Blood Flow Restriction Exercises Modulate Pain Sensitivity in Healthy Adults: A Systematic Review. Healthcare, 11.","DOI":"10.3390\/healthcare11050726"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1152\/japplphysiol.00543.2021","article-title":"Aerobic exercise with blood flow restriction causes local and systemic hypoalgesia and increases circulating opioid and endocannabinoid levels","volume":"131","author":"Hughes","year":"2021","journal-title":"J. Appl. Physiol."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Zheng, K., Chen, C., Yang, S., and Wang, X. (2021). Aerobic exercise attenuates pain sensitivity: An event-related potential study. Front. Neurosci., 15.","DOI":"10.3389\/fnins.2021.735470"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.physio.2023.12.002","article-title":"Effectiveness of myofascial release for adults with chronic neck pain: A meta-analysis","volume":"123","author":"Overmann","year":"2024","journal-title":"Physiotherapy"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"465","DOI":"10.52082\/jssm.2023.465","article-title":"Acute and long-term effects of static stretching on muscle-tendon stiffness: A systematic review","volume":"22","author":"Takeuchi","year":"2023","journal-title":"J. Sports Sci. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s40279-014-0288-1","article-title":"Exercise with blood flow restriction: An updated evidence-based approach for enhanced muscular development","volume":"45","author":"Scott","year":"2015","journal-title":"Sports Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"H132","DOI":"10.1152\/ajpheart.00820.2015","article-title":"Letter to the editor: Applying the blood flow restriction pressure: The elephant in the room","volume":"310","author":"Jessee","year":"2016","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3806\/ijktr.6.1","article-title":"Effects of low-intensity KAATSU resistance training on muscle size and endurance capacity in ischemic heart disease","volume":"6","author":"Nakajima","year":"2010","journal-title":"Int. J. KAATSU Train. 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