{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T19:53:56Z","timestamp":1769802836342,"version":"3.49.0"},"reference-count":39,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Research, Innovation and Digitalization through the National Recovery and Resilience Plan (PNRR) of Romania, Pillar III","award":["8 (I8)\u2014contract CF 68"],"award-info":[{"award-number":["8 (I8)\u2014contract CF 68"]}]},{"name":"Ministry of Research, Innovation and Digitalization","award":["23020101"],"award-info":[{"award-number":["23020101"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Patients undergoing chronic hemodialysis are at increased risk of severe COVID-19 outcomes. This study aimed to evaluate the clinical characteristics and prognostic factors associated with mortality in hemodialysis patients infected with SARS-CoV-2. Methods: We conducted a retrospective study including 130 chronic hemodialysis patients diagnosed with COVID-19 and admitted to a nephrology unit between March 2020 and April 2021. Demographic data, comorbidities, clinical manifestations, hospitalization duration, and outcomes were analyzed using univariate and multivariate statistical methods. Results: The cohort was predominantly male (64.6%), with a mean age of 64.0 \u00b1 13.9 years. The mean hospitalization duration was 13.6 \u00b1 9.7 days. Cardiovascular disease, chronic respiratory disease, dyspnea at presentation, and hospital-origin admission were significantly associated with mortality. While diabetes mellitus and hypertension were highly prevalent, they did not independently predict mortality after adjustment. Overall mortality was 34.6%, particularly among older patients with multiple comorbidities. Conclusions: COVID-19 infection is associated with substantial morbidity and mortality among patients on chronic hemodialysis. Early identification of high-risk patients based on clinical presentation and comorbidity profile may support timely intervention and improved outcomes in this vulnerable population.<\/jats:p>","DOI":"10.3390\/jcm15031067","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T10:08:57Z","timestamp":1769681337000},"page":"1067","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Manifestations and Mortality Predictors of COVID-19 in Patients Undergoing Chronic Hemodialysis: A Retrospective Cohort Study from Romania"],"prefix":"10.3390","volume":"15","author":[{"given":"Oana","family":"Nicolescu","sequence":"first","affiliation":[{"name":"Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8886-970X","authenticated-orcid":false,"given":"Mihaela Magdalena","family":"Mitache","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University Titu Maiorescu Bucharest, Gheorghe Petra\u0219cu 67A, 031592 Bucharest, Romania"},{"name":"Public Health Directorate, Avrig 72-74, District 2, 021578 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrei","family":"Mitache","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University Titu Maiorescu Bucharest, Gheorghe Petra\u0219cu 67A, 031592 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8968-504X","authenticated-orcid":false,"given":"Adelina-Gabriela","family":"Niculescu","sequence":"additional","affiliation":[{"name":"Research Institute of the University of Bucharest\u2014ICUB, University of Bucharest, \u0218oseaua Panduri 90, District 5, 050663 Bucharest, Romania"},{"name":"Department of Science and Engineering of Oxide Materials and Nanomaterials, National University of Science and Technology POLITEHNICA Bucharest, Splaiul Independen\u021bei 313, District 6, 060042 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4693-2105","authenticated-orcid":false,"given":"Dragos","family":"Garofil","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Dr. Carol Davila Clinical Hospital of Nephrology, Calea Grivi\u021bei 4, 010731 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor Dan Eugen","family":"Strambu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Dr. Carol Davila Clinical Hospital of Nephrology, Calea Grivi\u021bei 4, 010731 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Cochior","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University Titu Maiorescu Bucharest, Gheorghe Petra\u0219cu 67A, 031592 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Rusu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University Titu Maiorescu Bucharest, Gheorghe Petra\u0219cu 67A, 031592 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1362-6427","authenticated-orcid":false,"given":"Cosmin","family":"Moldovan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University Titu Maiorescu Bucharest, Gheorghe Petra\u0219cu 67A, 031592 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sorin","family":"Tudorache","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University Titu Maiorescu Bucharest, Gheorghe Petra\u0219cu 67A, 031592 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioana Ruxandra","family":"Poiana","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Spinu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Department of Urology, Central Military Hospital, Calea Plevnei 134, 010825 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice Elena","family":"Munteanu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University Titu Maiorescu Bucharest, Gheorghe Petra\u0219cu 67A, 031592 Bucharest, Romania"},{"name":"Army Cardiovascular Disease Center, Central Military Emergency University, Calea Plevnei 134, 010825 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marian","family":"Necula","sequence":"additional","affiliation":[{"name":"National Institute of Research and Development for Biological Sciences, 296 Splaiul Independentei, District 6, 060031 Bucharest, Romania"},{"name":"Faculty of Administration and Business, University of Bucharest, 030018 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2409-0966","authenticated-orcid":false,"given":"Corneliu Ovidiu","family":"Vrancianu","sequence":"additional","affiliation":[{"name":"Research Institute of the University of Bucharest\u2014ICUB, University of Bucharest, \u0218oseaua Panduri 90, District 5, 050663 Bucharest, Romania"},{"name":"National Institute of Research and Development for Biological Sciences, 296 Splaiul Independentei, District 6, 060031 Bucharest, Romania"},{"name":"Doctoral School, \u201cCarol Davila\u201d University of Medicine and Pharmacy, Eroii Sanitari 8, District 5, 050474 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4807-9470","authenticated-orcid":false,"given":"Ana Maria Alexandra","family":"St\u0103nescu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Academy of Romanian Scientists AOSR, Ilfov Street 3, District 5, 030167 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"628","DOI":"10.3390\/hearts5040048","article-title":"COVID-19 Pathophysiology: Inflammation to Cardiac Injury","volume":"5","author":"Fouda","year":"2024","journal-title":"Hearts"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"107582","DOI":"10.5527\/wjn.v14.i3.107582","article-title":"Kidney involvement and anemia in COVID-19 infection","volume":"14","author":"Gembillo","year":"2025","journal-title":"World J. 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