{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:51:11Z","timestamp":1791489071062,"version":"4.3.4"},"reference-count":24,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Objective: In this study, we aimed to develop and internally validate a clinically applicable nomogram for predicting live birth following in vitro fertilization (IVF) using routinely available clinical and embryological parameters. Methods: This retrospective study was conducted at a single tertiary IVF center. Women undergoing IVF\/ICSI were included if their baseline demographic and clinical data were available, they had undergone at least one fresh or frozen\u2013thawed embryo transfer, and they had a known live birth outcome. Women with cycles without embryo transfer and those missing key outcome data were excluded from the analysis. As a result, a total of 2119 IVF\/ICSI treatment cycles resulting in embryo transfer were included in the analysis. To identify independent predictors of live birth, multivariable logistic regression analysis was performed. Results: Among the 2119 treatment cycles analyzed, 541 resulted in live birth (25.5%). Multivariable logistic regression with backward stepwise selection identified female age (OR: 0.959, p &lt; 0.001), high embryo quality (OR: 2.752, p &lt; 0.001), day of embryo transfer (day 5 vs. day 3, OR: 1.427, p = 0.001), and endometrial thickness on the day of transfer as independent predictors of live birth (OR: 1.086, p &lt; 0.001). These variables were incorporated into a nomogram (the Z\u00fcbeyde Hanim IVF Nomogram) to estimate individualized live birth probability. The model demonstrated acceptable discrimination, with a bootstrap-corrected area under the receiver operating characteristic curve (AUC) of 0.64 (95%CI: 0.61\u20130.66), and it showed satisfactory calibration across deciles of predicted risk. Conclusions: The Zubeyde Hanim IVF Nomogram provides an individualized and clinically practical tool for predicting live birth following IVF treatment. Based on routinely available parameters, this model may assist clinicians in patient counseling and treatment planning.<\/jats:p>","DOI":"10.3390\/jcm15031077","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T12:49:07Z","timestamp":1769690947000},"page":"1077","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Clinically Applicable Nomogram for Live Birth Prediction After IVF: The Zubeyde Hanim Model"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9440-4193","authenticated-orcid":false,"given":"P\u0131nar","family":"Kara\u00e7in","sequence":"first","affiliation":[{"name":"Department of Gynecology, Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara 06200, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9267-8702","authenticated-orcid":false,"given":"Runa","family":"\u00d6zel\u00e7i","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Etlik City Hospital, Ankara 06200, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5080-0650","authenticated-orcid":false,"given":"Enes","family":"Kumcu","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Etlik City Hospital, Ankara 06200, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilek","family":"Kaya Kaplano\u011flu","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Adana Y\u00fcre\u011fir State Hospital, Adana 01200, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serdar","family":"Dilbaz","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Etlik City Hospital, Ankara 06200, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1011-3848","authenticated-orcid":false,"given":"Yaprak","family":"\u00dcst\u00fcn","sequence":"additional","affiliation":[{"name":"Department of Gynecology, \u0130zmir City Hospital, \u0130zmir 35200, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.fertnstert.2018.06.039","article-title":"International Committee for Monitoring Assisted Reproductive Technology: World report on assisted reproductive technology, 2011","volume":"110","author":"Adamson","year":"2018","journal-title":"Fertil. Steril."},{"key":"ref_2","first-page":"1786","article-title":"The international glossary on infertility and fertility care, 2017","volume":"32","author":"Adamson","year":"2017","journal-title":"Hum. Reprod."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/humupd\/dms043","article-title":"The ageing ovary and uterus: New biological insights","volume":"19","author":"Nelson","year":"2013","journal-title":"Hum. Reprod. Update"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Zhu, H., Zhao, C., Xiao, P., and Zhang, S. (2021). Predicting the likelihood of live birth in assisted reproductive technology according to the number of oocytes retrieved and female age using a generalized additive model: A retrospective cohort analysis of 17,948 cycles. Front. Endocrinol., 12.","DOI":"10.3389\/fendo.2021.606231"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.fertnstert.2022.10.014","article-title":"Markers of ovarian reserve as predictors of future fertility","volume":"119","author":"Harris","year":"2023","journal-title":"Fertil. Steril."},{"key":"ref_6","first-page":"131","article-title":"Embryo morphology and live birth in the United States","volume":"3","author":"Awadalla","year":"2022","journal-title":"FS Rep."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Li, N., Guan, Y., Ren, B., Zhang, Y., Du, Y., Kong, H., Zhang, Y., and Lou, H. (2022). Effect of blastocyst morphology and developmental rate on euploidy and live birth rates in preimplantation genetic testing for aneuploidy cycles with single-embryo transfer. Front. Endocrinol., 13.","DOI":"10.3389\/fendo.2022.858042"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"(2011). Alpha Scientists in Reproductive Medicine and ESHRE Special Interest Group of Embryology. The Istanbul consensus workshop on embryo assessment: Proceedings of an expert meeting. Hum. Reprod., 26, 1270\u20131283.","DOI":"10.1093\/humrep\/der037"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"hoaa009","DOI":"10.1093\/hropen\/hoaa009","article-title":"ESHRE guideline: Ovarian stimulation for IVF\/ICSI","volume":"2020","author":"Stimulation","year":"2020","journal-title":"Hum. Reprod. Open"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"i5735","DOI":"10.1136\/bmj.i5735","article-title":"Predicting the chances of a live birth after one or more complete cycles of in vitro fertilisation: Population based study of linked cycle data from 113 873 women","volume":"355","author":"McLernon","year":"2016","journal-title":"BMJ"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1093\/humrep\/dey263","article-title":"Predicting the cumulative chance of live birth over multiple complete cycles of in vitro fertilization: An external validation study","volume":"33","author":"Leijdekkers","year":"2018","journal-title":"Hum. Reprod."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.fertnstert.2016.12.005","article-title":"Which factors are most predictive for live birth after in vitro fertilization and intracytoplasmic sperm injection (IVF\/ICSI) treatments? Analysis of 100 prospectively recorded variables in 8,400 IVF\/ICSI single-embryo transfers","volume":"107","author":"Vaegter","year":"2017","journal-title":"Fertil. Steril."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1093\/humrep\/dev336","article-title":"Cumulative live birth rates after one or more complete cycles of IVF: A population-based study of linked cycle data from 178 898 women","volume":"31","author":"McLernon","year":"2016","journal-title":"Hum. Reprod."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"l869","DOI":"10.1136\/bmj.l869","article-title":"Role of maternal age and pregnancy history in risk of miscarriage: Prospective register based study","volume":"364","author":"Magnus","year":"2019","journal-title":"BMJ"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1093\/humrep\/deu053","article-title":"Association between response to ovarian stimulation and miscarriage following IVF: An analysis of 124 351 IVF pregnancies","volume":"29","author":"Sunkara","year":"2014","journal-title":"Hum. Reprod."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1093\/humupd\/8.2.141","article-title":"The variability of female reproductive ageing","volume":"8","author":"Pearson","year":"2002","journal-title":"Hum. Reprod. Update"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.tem.2007.01.004","article-title":"Female reproductive ageing: Current knowledge and future trends","volume":"18","author":"Broekmans","year":"2007","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/S0015-0282(01)03243-5","article-title":"A prediction model for selecting patients undergoing in vitro fertilization for elective single embryo transfer","volume":"77","author":"Hunault","year":"2002","journal-title":"Fertil. Steril."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1093\/humrep\/14.9.2345","article-title":"Characterization of a top quality embryo, a step towards single-embryo transfer","volume":"14","author":"Mangelschots","year":"1999","journal-title":"Hum. Reprod."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s10815-006-9082-9","article-title":"Pregnancy prediction models and eSET criteria for IVF patients\u2013do we need more information?","volume":"24","author":"Ottosen","year":"2007","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_21","first-page":"CD002118","article-title":"Cleavage-stage versus blastocyst-stage embryo transfer in assisted reproductive technology","volume":"5","author":"Glujovsky","year":"2022","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"23","DOI":"10.4103\/0974-1208.51339","article-title":"Blastocyst stage transfer vs cleavage stage embryo transfer","volume":"2","author":"Mangalraj","year":"2009","journal-title":"J. Hum. Reprod. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/1477-7827-10-100","article-title":"The effect of endometrial thickness and pattern measured by ultrasonography on pregnancy outcomes during IVF-ET cycles","volume":"10","author":"Zhao","year":"2012","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1093\/humupd\/dmu011","article-title":"Endometrial thickness and pregnancy rates after IVF: A systematic review and meta-analysis","volume":"20","author":"Kasius","year":"2014","journal-title":"Hum. Reprod. 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