{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T06:06:21Z","timestamp":1769753181232,"version":"3.49.0"},"reference-count":100,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Superficial venous thrombosis (SVT) is an inflammatory and thrombotic disorder affecting superficial veins. While varicose veins (VVs) are the primary risk factor, SVT occurring in non-varicose veins (NVVs) is a critical clinical finding, often acting as a sentinel marker for severe systemic pathologies. Aims: This review aims at examining incidence, mechanisms, underlying causes, and clinical outcomes of SVT within the NVV population. Materials and Methods: We conducted a comprehensive narrative review of the existing medical literature. Results: SVT in NVVs is frequently associated with systemic conditions, including inherited or acquired thrombophilia, visceral or hematologic malignancies (notably Trousseau\u2019s syndrome), vasculitis (e.g., Beh\u00e7et\u2019s syndrome), and connective tissue disorders. Specific manifestations like migratory SVT or Mondor\u2019s disease provide crucial diagnostic clues. Notably, NVV-SVT carries a significantly higher risk of recurrence and venous thromboembolic events compared to VV-associated cases. Conclusions: A thorough diagnostic work-up is essential for patients with NVV-SVT to ensure early detection of underlying systemic diseases. Although current management does not differentiate between VV and NVV cases, the increased thromboembolic risk in the latter suggests a need for tailored therapeutic approaches. Further prospective studies are required to evaluate differentiated anticoagulant strategies regarding dosage and duration for this high-risk population.<\/jats:p>","DOI":"10.3390\/jcm15031082","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T14:52:36Z","timestamp":1769698356000},"page":"1082","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Superficial Venous Thrombosis in Non-Varicose Veins: A Narrative Review"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1196-9073","authenticated-orcid":false,"given":"Marco","family":"Mangiafico","sequence":"first","affiliation":[{"name":"Unit of Internal Medicine, Policlinico \u201cG. Rodolico-San Marco\u201d University Hospital, University of Catania, 95123 Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco Lorenzo","family":"Di Pino","sequence":"additional","affiliation":[{"name":"Unit of Internal Medicine, Policlinico \u201cG. Rodolico-San Marco\u201d University Hospital, University of Catania, 95123 Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3595-3461","authenticated-orcid":false,"given":"Luca","family":"Costanzo","sequence":"additional","affiliation":[{"name":"Unit of Angiology, Cardio-Thoraco-Vascular Department, Policlinico \u201cG. Rodolico-San Marco\u201d University Hospital, University of Catania, 95123 Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"h2039","DOI":"10.1136\/bmj.h2039","article-title":"Superficial Thrombophlebitis (Superficial Venous Thrombosis)","volume":"350","author":"Nasr","year":"2015","journal-title":"BMJ"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1002\/jum.15737","article-title":"Ultrasound Imaging of Superficial Venous Thrombosis in the Upper and Lower Extremities: Closing the Gap Between Clinical Management Guidelines and Ultrasound Practice Parameters","volume":"41","author":"Smith","year":"2022","journal-title":"J. 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