{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:45:08Z","timestamp":1777383908537,"version":"3.51.4"},"reference-count":27,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Acute mesenteric ischemia (AMI) is a time-dependent condition associated with exceptionally high in-hospital mortality, particularly among elderly and comorbid patients. Early identification of patients at high risk of death remains challenging and has important implications for clinical decision-making. The objective of this study was to derive and internally validate a prognostic score for in-hospital mortality of patients with AMI. Materials and Methods: We conducted a multicenter, observational, retrospective cohort study including patients with AMI from 10 participating hospitals. A descriptive and analytical approach was performed. A Classification and Regression Tree (CART) model was used to determine cut-off points for continuous variables and assess their association with mortality. Based on these thresholds, a univariate analysis was performed, and variables with statistical significance (p &lt; 0.05) were incorporated into a multivariate logistic regression model. A score\u2014the RADIAL score\u2014was then derived from the beta coefficients. The discriminative ability of the score was evaluated using the receiver operating characteristic (ROC) curve. Results: A total of 693 patients were studied. Thee mean age was 81 years (IQR 73\u201386) and 54.2% were women. A history of cardiovascular disease was present in 75.3% of participants. Overall mortality was 62.4%. Most patients (74%) were managed conservatively. Significant variables in the bivariate analysis included hypotension, age &gt; 65 years, pH &lt; 7.3, creatinine &gt; 1.7 mg\/dL, and absence of rectal bleeding. These variables were incorporated into the multivariate model. The resulting score showed an area under the ROC curve of 0.78 (95% CI: 0.74\u20130.82). Conclusions: The RADIAL score demonstrated robust predictive performance and allowed the identification of three mortality-risk groups: 30\u201340% (low), 50\u201360% (intermediate), and 80% (high). This tool may support clinical decision-making in the management of patients with AMI.<\/jats:p>","DOI":"10.3390\/jcm15031106","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T14:35:46Z","timestamp":1769783746000},"page":"1106","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Predicting In-Hospital Mortality in Acute Mesenteric Ischemia: The RADIAL Score"],"prefix":"10.3390","volume":"15","author":[{"given":"Luis","family":"Castilla-Guerra","sequence":"first","affiliation":[{"name":"Vascular Risk Unit, Internal Medicine Department, Hospital University Virgen Macarena, 41009 Seville, Spain"},{"name":"Department of Medicine, University of Seville, 41009 Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Luque-Linero","sequence":"additional","affiliation":[{"name":"Vascular Risk Unit, Internal Medicine Department, Hospital University Virgen Macarena, 41009 Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria del Carmen","family":"Fernandez-Moreno","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Seville, 41009 Seville, Spain"},{"name":"Neurology Department, Virgen de Valme Hospital, 41014 Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bel\u00e9n","family":"Guti\u00e9rrez-Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Seville, 41009 Seville, Spain"},{"name":"Clinical Unit of Infectious Diseases and Microbiology, Hospital University Virgen Macarena, 41009 Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Fuentes-Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Reina Sof\u00eda University Hospital, 14004 C\u00f3rdoba, Spain"},{"name":"Faculty of Medicine, University of Medicine of C\u00f3rdoba, 14071 C\u00f3rdoba, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Adoraci\u00f3n","family":"Mart\u00edn-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Nephrology Department, Poniente University Hospital, 04700 El Ejido, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Dolores","family":"Mart\u00ednez-Esteban","sequence":"additional","affiliation":[{"name":"Nephrology Department, Regional University Hospital, 29010 M\u00e1laga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda del Pilar","family":"Segura-Torres","sequence":"additional","affiliation":[{"name":"Nephrology Department, University Hospital of Jaen, 23007 Ja\u00e9n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9333-076X","authenticated-orcid":false,"given":"Maria Dolores","family":"L\u00f3pez-Carmona","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Regional University Hospital, 29007 M\u00e1laga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1843-0431","authenticated-orcid":false,"given":"Patricia","family":"Rubio-Mar\u00edn","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital Universitario de Jerez, 11407 Jerez de la Frontera, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,30]]},"reference":[{"key":"ref_1","first-page":"417","article-title":"Mesenteric Ischemia","volume":"37","author":"Audu","year":"2023","journal-title":"Clin. 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