{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:37:02Z","timestamp":1770251822247,"version":"3.49.0"},"reference-count":32,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Inflammatory bowel disease (IBD) has widely been associated with various extraintestinal complications, including kidney disease. The literature suggests that IBD patients are at increased risk of developing chronic kidney disease (CKD). This study aims to assess the relationship between IBD and CKD, and to identify risk factors associated with CKD in patients with IBD. Methods: Data for hospitalized patients with IBD was obtained from The National Inpatient Sample (NIS) database from 2016 to 2020. Baseline risk factors were identified using ICD-10 codes. Patients were stratified into two groups: Crohn\u2019s Disease (CD) and Ulcerative Colitis (UC). Primary outcomes were prevalence and risk factors of CKD. Secondary outcomes were mortality and length of hospital stay (LOS). Univariate and multivariate analyses were conducted using SPSS v. 30. Results: We identified 230,766 patients with IBD: 144,847 (63%) had CD and 85,919 (37%) had UC. After 1:1 matching, 148,498 patients were included: 74,249 with CD and 74,249 with UC. In this study group, the prevalence of CKD in patients with CD and patients with UC was the same (7.2%). CD patients with CKD had lower in-hospital mortality rates and lower in-hospital length of stay compared to UC patients with CKD. Conclusions: While the prevalence of CKD is similar amongst CD and UC patients, the risk factors and outcomes such as mortality and length of hospitalization differ significantly. This study emphasizes the need for tailored approaches and closer monitoring for the risk of developing CKD in IBD patients and especially patients with UC.<\/jats:p>","DOI":"10.3390\/jcm15031157","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T12:00:47Z","timestamp":1770033647000},"page":"1157","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the Link Between Inflammatory Bowel Disease and Chronic Kidney Disease: A Nationwide Database Study"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2346-8733","authenticated-orcid":false,"given":"Chloe","family":"Lahoud","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Staten Island University Hospital, Northwell Health, New York, NY 10305, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9000-3534","authenticated-orcid":false,"given":"Ali","family":"Sohail","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Staten Island University Hospital, Northwell Health, New York, NY 10305, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3551-4066","authenticated-orcid":false,"given":"Toni","family":"Habib","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Staten Island University Hospital, Northwell Health, New York, NY 10305, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3158-4120","authenticated-orcid":false,"given":"Omar","family":"Abureesh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Staten Island University Hospital, Northwell Health, New York, NY 10305, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chapman","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Staten Island University Hospital, Northwell Health, New York, NY 10305, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne","family":"El Sayegh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Staten Island University Hospital, Northwell Health, New York, NY 10305, USA"},{"name":"Department of Nephrology, Staten Island University Hospital, Northwell Health, New York, NY 10305, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliane","family":"Deeb","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Staten Island University Hospital, Northwell Health, New York, NY 10305, USA"},{"name":"Department of Gastroenterology and Hepatology, Staten Island University Hospital, Northwell Health, New York, NY 10305, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4798","DOI":"10.3748\/wjg.v24.i42.4798","article-title":"Increased end-stage renal disease risk in patients with inflammatory bowel disease: A nationwide population-based study","volume":"24","author":"Park","year":"2018","journal-title":"World J. Gastroenterol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1016\/j.cgh.2019.10.043","article-title":"Inflammatory Bowel Diseases Are Associated with an Increased Risk for Chronic Kidney Disease, Which Decreases with Age","volume":"18","author":"Vajravelu","year":"2020","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.amepre.2023.08.008","article-title":"Inflammatory Bowel Disease with Chronic Kidney Disease and Acute Kidney Injury","volume":"65","author":"Liu","year":"2023","journal-title":"Am. J. Prev. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1056\/NEJMra2002697","article-title":"Pathophysiology of Inflammatory Bowel Diseases","volume":"383","author":"Chang","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nri3661","article-title":"Cytokines in inflammatory bowel disease","volume":"14","author":"Neurath","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1097\/MIB.0000000000000392","article-title":"Extraintestinal Manifestations of Inflammatory Bowel Disease","volume":"21","author":"Vavricka","year":"2015","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1093\/ecco-jcc\/jjv213","article-title":"The First European Evidence-based Consensus on Extra-intestinal Manifestations in Inflammatory Bowel Disease","volume":"10","author":"Harbord","year":"2016","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1093\/ecco-jcc\/jjv138","article-title":"Renal Involvement in Inflammatory Bowel Diseases","volume":"10","author":"Corica","year":"2016","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1093\/ibd\/izac140","article-title":"Renal and Urological Disorders Associated with Inflammatory Bowel Disease","volume":"29","author":"Kumar","year":"2023","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.pop.2008.01.005","article-title":"Nephrolithiasis","volume":"35","author":"Worcester","year":"2008","journal-title":"Prim. Care"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"265","DOI":"10.2215\/CJN.04660513","article-title":"The histopathologic spectrum of kidney biopsies in patients with inflammatory bowel disease","volume":"9","author":"Ambruzs","year":"2014","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Liang, Z., Hu, X., Lin, R., Tang, Z., Ye, Z., Mao, R., Chen, W., and Zhou, Y. (2023). Identification of shared gene signatures and molecular mechanisms between chronic kidney disease and ulcerative colitis. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1078310"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group (2024). KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney Int., 105, S117\u2013S314.","DOI":"10.1016\/j.kint.2023.10.018"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Hill, N.R., Fatoba, S.T., Oke, J.L., Hirst, J.A., O\u2019Callaghan, C.A., Lasserson, D.S., and Hobbs, F.D.R. (2016). Global Prevalence of Chronic Kidney Disease\u2014A Systematic Review and Meta-Analysis. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0158765"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1038\/ki.2015.230","article-title":"A systematic analysis of worldwide population-based data on the global burden of chronic kidney disease in 2010","volume":"88","author":"Mills","year":"2015","journal-title":"Kidney Int."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.kisu.2021.11.003","article-title":"Epidemiology of chronic kidney disease: An update 2022","volume":"12","author":"Kovesdy","year":"2022","journal-title":"Kidney Int. Suppl."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2180373","DOI":"10.1155\/2018\/2180373","article-title":"Inflammation-Related Mechanisms in Chronic Kidney Disease Prediction, Progression, and Outcome","volume":"2018","author":"Mihai","year":"2018","journal-title":"J. Immunol. Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1093\/ecco-jcc\/jjae049","article-title":"Chronic Kidney Disease in Inflammatory Bowel Disease: A Systematic Review and Meta-analysis","volume":"18","author":"Zadora","year":"2024","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Lian, X., Wang, Y., Wang, S., Peng, X., Wang, Y., Huang, Y., and Chen, W. (2023). Does inflammatory bowel disease promote kidney diseases: A mendelian randomization study with populations of European ancestry. BMC Med. Genom., 16.","DOI":"10.1186\/s12920-023-01644-2"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1016\/j.cgh.2024.05.010","article-title":"Risk of Kidney Failure in Patients with Inflammatory Bowel Disease Undergoing Colectomy: A Nationwide Cohort Study","volume":"22","author":"Yang","year":"2024","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/s41581-019-0172-1","article-title":"Intestinal microbiome and fitness in kidney disease","volume":"15","author":"Meijers","year":"2019","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1007\/s11255-019-02291-2","article-title":"The gut microbiota and its relationship with chronic kidney disease","volume":"51","author":"Plata","year":"2019","journal-title":"Int. Urol. Nephrol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/ecco-jcc\/jjv219","article-title":"Clinical Features and HLA Association of 5-Aminosalicylate (5-ASA)-induced Nephrotoxicity in Inflammatory Bowel Disease","volume":"10","author":"Heap","year":"2016","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1038\/ajg.2015.233","article-title":"Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE): Determining Therapeutic Goals for Treat-to-Target","volume":"110","author":"Sandborn","year":"2015","journal-title":"Am. J. Gastroenterol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.dld.2021.11.008","article-title":"Kidney function monitoring in inflammatory bowel disease: The MONITORED consensus","volume":"54","author":"Guillo","year":"2022","journal-title":"Dig. Liver Dis."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1016\/j.cgh.2020.10.040","article-title":"Link Between Inflammatory Bowel Disease and Risk of Chronic Kidney Disease","volume":"19","author":"Wang","year":"2021","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1016\/j.cgh.2020.11.031","article-title":"Reply","volume":"19","author":"Vajravelu","year":"2021","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"17562848211023399","DOI":"10.1177\/17562848211023399","article-title":"The elderly IBD patient in the modern era: Changing paradigms in risk stratification and therapeutic management","volume":"14","author":"Hong","year":"2021","journal-title":"Ther. Adv. Gastroenterol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1681\/ASN.2013010113","article-title":"APOL1 Variants Associate with Increased Risk of CKD among African Americans","volume":"24","author":"Foster","year":"2013","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1053\/j.gastro.2020.08.064","article-title":"Effects of Race and Ethnicity on Diagnosis and Management of Inflammatory Bowel Diseases","volume":"160","author":"Barnes","year":"2021","journal-title":"Gastroenterology"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1093\/ecco-jcc\/jjz117","article-title":"Systemic Molecular Mediators of Inflammation Differentiate Between Crohn\u2019s Disease and Ulcerative Colitis, Implicating Threshold Levels of IL-10 and Relative Ratios of Pro-inflammatory Cytokines in Therapy","volume":"14","author":"Kiernan","year":"2020","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Han, X., Xu, Z., Chang, Y., Li, H., Hu, S., Chang, S., Liu, Y., Yu, C., Tang, T., and Li, Y. (2024). Concurrent chronic kidney disease in patients with inflammatory bowel disease, a systematic review and meta-analysis. Front. Med., 11.","DOI":"10.3389\/fmed.2024.1485087"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/3\/1157\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T12:21:24Z","timestamp":1770034884000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/3\/1157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,2]]},"references-count":32,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,2]]}},"alternative-id":["jcm15031157"],"URL":"https:\/\/doi.org\/10.3390\/jcm15031157","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,2]]}}}