{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T23:25:47Z","timestamp":1770161147496,"version":"3.49.0"},"reference-count":49,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Pain is a common and clinically important symptom in hemodialysis, yet its functional impact and determinants remain insufficiently characterized. This study examined factors associated with pain interference using the Pain Effects Scale (PES) in maintenance hemodialysis patients. Methods: In a cross-sectional study, 73 adults receiving thrice-weekly hemodialysis completed the PES, assessing the four-week impact of pain on mood, sleep, mobility, work, recreation, and enjoyment of life. Demographic, clinical, and dialysis-related variables\u2014including vascular access type, dialysis vintage, session duration, ultrafiltration volume, predialysis urea, Kt\/V, urea reduction ratio, comorbidities, and transplant history\u2014were extracted from medical records. Associations were evaluated using parametric and non-parametric tests. Results: PES scores indicated substantial pain interference. Older age was positively correlated with higher PES scores (r = 0.32, p = 0.006), and patients with ischemic heart disease had significantly higher PES values than those without (23.1 \u00b1 6.7 vs. 17.3 \u00b1 6.2; p = 0.012). Willingness to pursue transplantation showed a non-significant trend toward lower scores. Conclusions: Pain interference in hemodialysis appears largely independent of routine adequacy metrics and most comorbidities, with ischemic cardiovascular disease emerging as an exception. Findings underscore the need for a biopsychosocial approach integrating pain screening with assessment of mood, sleep, neuropathy, musculoskeletal factors, and ischemic symptoms.<\/jats:p>","DOI":"10.3390\/jcm15031184","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T10:03:29Z","timestamp":1770113009000},"page":"1184","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pain Interference in Maintenance Hemodialysis: A Single-Center Cross-Sectional Study Using the Pain Effects Scale (PES)"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8236-223X","authenticated-orcid":false,"given":"Leszek","family":"Su\u0142kowski","sequence":"first","affiliation":[{"name":"Department of General Surgery, Regional Specialist Hospital, Bialska 104\/118, 42-218 Cz\u0119stochowa, Poland"},{"name":"Faculty of Medicine, Jan Dlugosz University in Czestochowa, Waszyngtona 4\/8, 42-217 Cz\u0119stochowa, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrzej","family":"Matyja","sequence":"additional","affiliation":[{"name":"2nd Department of General Surgery, Medical College, Jagiellonian University, 30-688 Krak\u00f3w, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7068-9355","authenticated-orcid":false,"given":"Maciej","family":"Matyja","sequence":"additional","affiliation":[{"name":"2nd Department of General Surgery, Medical College, Jagiellonian University, 30-688 Krak\u00f3w, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1053\/j.ackd.2006.10.001","article-title":"The prevalence of symptoms in end-stage renal disease: A systematic review","volume":"14","author":"Murtagh","year":"2007","journal-title":"Adv. Chronic Kidney Dis."},{"key":"ref_2","first-page":"1131","article-title":"Prevalence and severity of pain in adult end-stage renal disease patients on chronic intermittent hemodialysis: A systematic review","volume":"10","author":"Brkovic","year":"2016","journal-title":"Patient Prefer. Adherence"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1681\/ASN.2005020157","article-title":"Prevalence, severity, and importance of physical and emotional symptoms in chronic hemodialysis patients","volume":"16","author":"Weisbord","year":"2005","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.jpainsymman.2005.05.013","article-title":"The impact of chronic pain on depression, sleep, and the desire to withdraw from dialysis in hemodialysis patients","volume":"30","author":"Davison","year":"2005","journal-title":"J. Pain Symptom Manag."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1038\/sj.ki.5000184","article-title":"Cross-sectional validity of a modified Edmonton symptom assessment system in dialysis patients: A simple assessment of symptom burden","volume":"69","author":"Davison","year":"2006","journal-title":"Kidney Int."},{"key":"ref_6","first-page":"E144","article-title":"Similar prevalence but different characteristics of pain in kidney transplant recipients and chronic hemodialysis patients","volume":"25","author":"Pietrasik","year":"2011","journal-title":"Clin. Transplant."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/sdi.12196","article-title":"Pain in chronic kidney disease: A scoping review","volume":"27","author":"Davison","year":"2014","journal-title":"Semin. Dial."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1046\/j.1523-1755.2003.00072.x","article-title":"Health-related quality of life as a predictor of mortality and hospitalization: The Dialysis Outcomes and Practice Patterns Study (DOPPS)","volume":"64","author":"Mapes","year":"2003","journal-title":"Kidney Int."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"341","DOI":"10.5414\/CNP60341","article-title":"Quality of life in patients treated with hemodialysis or peritoneal dialysis: What are the important determinants?","volume":"60","author":"Manns","year":"2003","journal-title":"Clin. Nephrol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"227","DOI":"10.37526\/1526-744X.2022.49.3.227","article-title":"Exploring the Evidence: Symptom Burden in Chronic Kidney Disease","volume":"49","author":"Rivera","year":"2022","journal-title":"Nephrol. Nurs. J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.2215\/CJN.00430109","article-title":"Symptom burden, depression, and quality of life in chronic and end-stage kidney disease","volume":"4","author":"Unruh","year":"2009","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"136","DOI":"10.2337\/dc16-2042","article-title":"Diabetic Neuropathy: A Position Statement by the American Diabetes Association","volume":"40","author":"Boulton","year":"2017","journal-title":"Diabetes Care"},{"key":"ref_13","first-page":"e6903","article-title":"Pain Assessment in Hemodialysis Patients","volume":"12","author":"Sadigova","year":"2020","journal-title":"Cureus"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1053\/j.ajkd.2014.06.024","article-title":"Patients\u2019 perspectives on hemodialysis vascular access: A systematic review of qualitative studies","volume":"64","author":"Casey","year":"2014","journal-title":"Am. J. Kidney Dis."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.2215\/CJN.02730312","article-title":"A randomized trial comparing buttonhole with rope ladder needling in conventional hemodialysis patients","volume":"7","author":"MacRae","year":"2012","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.kint.2016.10.033","article-title":"Frequent Hemodialysis Network Trial Investigators. Patients receiving frequent hemodialysis have better health-related quality of life compared to patients receiving conventional hemodialysis","volume":"91","author":"Garg","year":"2017","journal-title":"Kidney Int."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1093\/ndt\/11.supp8.38","article-title":"Sodium and water profiling in chronic uraemia","volume":"11","author":"Churchill","year":"1996","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"S79","DOI":"10.1016\/S0085-2538(15)47404-6","article-title":"Sodium modeling","volume":"76","author":"Mann","year":"2000","journal-title":"Kidney Int. Suppl."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.2215\/CJN.0000000000000524","article-title":"Diurnal and Daily Symptom Variation in Patients with End Stage Kidney Disease: An Ecological Momentary Assessment Study","volume":"19","author":"Kallem","year":"2024","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"261","DOI":"10.2215\/CJN.03890609","article-title":"Temporal trends in health-related quality of life among hemodialysis patients in the United States","volume":"5","author":"Gabbay","year":"2010","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"782","DOI":"10.2215\/CJN.10601011","article-title":"Frequent Hemodialysis Network Trial Group. Effects of six versus three times per week hemodialysis on physical performance, health, and functioning: Frequent Hemodialysis Network (FHN) randomized trials","volume":"7","author":"Hall","year":"2012","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1159\/000327207","article-title":"Nocturnal home hemodialysis: Which of your patients should choose this modality?","volume":"171","author":"Rocco","year":"2011","journal-title":"Contrib. Nephrol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1001\/jama.298.11.1291","article-title":"Effect of frequent nocturnal hemodialysis vs conventional hemodialysis on left ventricular mass and quality of life: A randomized controlled trial","volume":"298","author":"Culleton","year":"2007","journal-title":"JAMA"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1046\/j.1523-1755.2003.00064.x","article-title":"Nonadherence in hemodialysis: Associations with mortality, hospitalization, and practice patterns in the DOPPS","volume":"64","author":"Saran","year":"2003","journal-title":"Kidney Int."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/BF00451725","article-title":"Development of the kidney disease quality of life (KDQOL) instrument","volume":"3","author":"Hays","year":"1994","journal-title":"Qual. Life Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.semnephrol.2021.10.007","article-title":"Emerging Patient-Centered Concepts in Pain Among Adults With Chronic Kidney Disease, Maintenance Dialysis, and Kidney Transplant","volume":"41","author":"Lockwood","year":"2021","journal-title":"Semin. Nephrol."},{"key":"ref_27","unstructured":"Ritvo, P.G., Fischer, J.S., Miller, D.M., Andrews, H., Paty, D.W., and LaRocca, N.G. (1997). Multiple Sclerosis Quality of Life Inventory: A User\u2019s Manual, National Multiple Sclerosis Society."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Stewart, A.L., and Ware, J.E. (1992). Measuring Functioning and Well-Being: The Medical Outcomes Study Approach, Duke University Press.","DOI":"10.7249\/CB361"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1097\/00005650-199206000-00002","article-title":"The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection","volume":"30","author":"Ware","year":"1992","journal-title":"Med. Care"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/papr.12594","article-title":"Risk Factors Associated with Pain on Chronic Intermittent Hemodialysis: A Systematic Review","volume":"18","author":"Brkovic","year":"2018","journal-title":"Pain Pract."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"708","DOI":"10.2215\/CJN.00170107","article-title":"Association of initial hemodialysis vascular access with patient-reported health status and quality of life","volume":"2","author":"Wasse","year":"2007","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/ki.2010.383","article-title":"Rapid fluid removal during dialysis is associated with cardiovascular morbidity and mortality","volume":"79","author":"Flythe","year":"2011","journal-title":"Kidney Int."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"14851","DOI":"10.1038\/s41598-024-65603-2","article-title":"Prevalence and factors associated with the correlation between malnutrition and pain in hemodialysis patients","volume":"14","author":"Jaber","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Marzouq, M.K., Samoudi, A.F., Samara, A., Zyoud, S.H., and Al-Jabi, S.W. (2021). Exploring factors associated with pain in hemodialysis patients: A multicenter cross-sectional study from Palestine. BMC Nephrol., 22.","DOI":"10.1186\/s12882-021-02305-1"},{"key":"ref_35","first-page":"1261","article-title":"Factors Associated with the Social Support of Hemodialysis Patients","volume":"45","author":"Theodoritsi","year":"2016","journal-title":"Iran J. Public Health"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Su\u0142kowski, L., Matyja, A., and Matyja, M. (2025). Fatigue in Hemodialysis Patients: A Comparative Analysis with Healthy Controls. Eur. J. Investig. Health Psychol. Educ., 15.","DOI":"10.3390\/ejihpe15020012"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Su\u0142kowski, L., Matyja, A., and Matyja, M. (2025). The Role of Age in Shaping Cognitive, Physical, and Psychosocial Outcomes in Hemodialysis Patients: A Cross-Sectional Study. Medicina, 61.","DOI":"10.3390\/medicina61071295"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Su\u0142kowski, L., Rubinkiewicz, M., Matyja, A., and Matyja, M. (2023). Visual Impairment in Hemodialyzed Patients-An IVIS Study. Medicina, 59.","DOI":"10.3390\/medicina59061106"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Su\u0142kowski, L., Matyja, A., and Matyja, M. (2024). Social Support and Quality of Life in Hemodialysis Patients: A Comparative Study with Healthy Controls. Medicina, 60.","DOI":"10.3390\/medicina60111732"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Su\u0142kowski, L., Matyja, A., and Matyja, M. (2025). The Impact of Dialysis Duration on Multidimensional Health Outcomes: A Cross-Sectional Study. J. Clin. Med., 14.","DOI":"10.3390\/jcm14020376"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"659","DOI":"10.2215\/CJN.08151109","article-title":"Fatigue is a predictor for cardiovascular outcomes in patients undergoing hemodialysis","volume":"5","author":"Koyama","year":"2010","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Su\u0142kowski, L., Matyja, A., and Matyja, M. (2025). Determinants of Sexual Satisfaction in Hemodialysis Patients: A Cross-Sectional Analysis with Healthy Controls. Medicina, 61.","DOI":"10.3390\/medicina61122171"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.pmn.2022.08.013","article-title":"Pain Interference in End Stage Kidney Disease is Associated with Changes in Gut Microbiome Features Before and After Kidney Transplantation","volume":"24","author":"Lockwood","year":"2023","journal-title":"Pain Manag. Nurs."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.2215\/CJN.19031220","article-title":"Kidney Disease Symptoms before and after Kidney Transplantation","volume":"16","author":"Taylor","year":"2021","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1016\/j.transproceed.2014.03.008","article-title":"Attitude of hemodialysis patients toward renal transplantation: A Moroccan Interregional Survey","volume":"46","author":"Kabbali","year":"2014","journal-title":"Transplant. Proc."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1093\/ckj\/sfx057","article-title":"Symptom burden in patients with chronic kidney disease not requiring renal replacement therapy","volume":"10","author":"Brown","year":"2017","journal-title":"Clin. Kidney J."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"A\u0161\u0107eri\u0107, R.R., Dimkovi\u0107, N.B., Trajkovi\u0107, G.\u017d., Risti\u0107, B.S., Jankovi\u0107, A.N., Duri\u0107, P.S., and Ilijevski, N.S. (2019). Prevalence, clinical characteristics, and predictors of peripheral arterial disease in hemodialysis patients: A cross-sectional study. BMC Nephrol., 20.","DOI":"10.1186\/s12882-019-1468-x"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.xkme.2021.05.007","article-title":"Health-Related Quality of Life in Older Kidney Transplant Recipients: A National Cohort Study of Short- and Longer-Term Outcomes","volume":"3","author":"Tsarpali","year":"2021","journal-title":"Kidney Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1365-2702.2007.01994.x","article-title":"A structured literature review of pain assessment and management of patients with chronic kidney disease","volume":"17","author":"Williams","year":"2008","journal-title":"J. Clin. Nurs."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/3\/1184\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T10:26:52Z","timestamp":1770114412000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/3\/1184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,3]]},"references-count":49,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,2]]}},"alternative-id":["jcm15031184"],"URL":"https:\/\/doi.org\/10.3390\/jcm15031184","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,3]]}}}