{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T05:29:26Z","timestamp":1770182966166,"version":"3.49.0"},"reference-count":25,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Inflammatory bowel disease (IBD) is associated with chronic pain and reduced quality of life, even in the absence of active intestinal inflammation. International studies suggest that fibromyalgia (FM), a chronic pain disorder characterized by widespread musculoskeletal pain, fatigue, sleep disturbance, and multiple somatic symptoms, is more prevalent among patients with IBD than among the general population. However, data from Saudi Arabia are limited. Methods: This cross-sectional study was conducted at King Abdulaziz University Hospital in Jeddah, Saudi Arabia, during July and August of 2024. Patients with biopsy-confirmed IBD were identified from hospital records and contacted by phone to screen for FM using a validated Arabic version of the Fibromyalgia Rapid Screening Tool. Demographic data, comorbidities, medication exposure, IBD characteristics, disease activity, and laboratory parameters were extracted from the medical records and compared between patients with and without FM. Results: Of 274 patients with IBD (mean age 30.9 \u00b1 9.2 years; 56.9% male), 51 (18.6%; 95% CI 14.2\u201323.7) met criteria for FM. Patients with FM tended to be older than those without and were more likely to have comorbidities, particularly thyroid disorders, as well as low Vitamin D levels. Prior 5-aminosalicylic acid use was also more common among patients with FM. Inflammatory markers, hematological indices, IBD phenotypes, and disease activity were similar between the groups. Conclusions: Saudi patients with IBD often have comorbid FM. Routine FM screening in IBD clinics may help avoid misattributing central pain to active inflammation and unnecessary treatment escalation.<\/jats:p>","DOI":"10.3390\/jcm15031203","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T16:46:28Z","timestamp":1770137188000},"page":"1203","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence and Clinical Correlates of Fibromyalgia Screening Positivity in Patients with Inflammatory Bowel Disease"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0170-3747","authenticated-orcid":false,"given":"Mohammad","family":"Mustafa","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, University of Jeddah, Jeddah 23218, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5060-3884","authenticated-orcid":false,"given":"Yasser","family":"Bawazir","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah 22254, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariam","family":"Mukhtar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah 22254, Saudi Arabia"},{"name":"Inflammatory Bowel Disease Research Group, King Abdulaziz University, Jeddah 22254, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6975-1297","authenticated-orcid":false,"given":"Mahmoud","family":"Mosli","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah 22254, Saudi Arabia"},{"name":"Inflammatory Bowel Disease Research Group, King Abdulaziz University, Jeddah 22254, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0473-4920","authenticated-orcid":false,"given":"Nadeem","family":"Butt","sequence":"additional","affiliation":[{"name":"Department of Family and Community Medicine, Faculty of Medicine Rabigh, King Abdulaziz University, Jeddah 22254, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana","family":"Jahhaf","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, King Khalid University Hospital, Riyadh 12372, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalid","family":"Alghamdi","sequence":"additional","affiliation":[{"name":"School of Medicine, King Abdulaziz University, Jeddah 22254, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4168-4985","authenticated-orcid":false,"given":"Roaa","family":"Alsolaimani","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah 22254, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.autrev.2013.06.006","article-title":"Rheumatic manifestations in inflammatory bowel disease","volume":"13","author":"Atzeni","year":"2014","journal-title":"Autoimmun. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1002\/ibd.20942","article-title":"Musculoskeletal manifestations of inflammatory bowel disease","volume":"15","author":"Bourikas","year":"2009","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_3","first-page":"283","article-title":"Musculoskeletal manifestation in inflammatory bowel disease","volume":"73","author":"Kim","year":"2019","journal-title":"Korean J. Gastroenterol."},{"key":"ref_4","first-page":"584573","article-title":"The prevalence of fibromyalgia in other chronic pain conditions","volume":"2012","author":"Yunus","year":"2012","journal-title":"Pain Res. Treat."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Bawazir, Y. (2023). Prevalence of fibromyalgia syndrome in Saudi Arabia: A systematic review and meta-analysis. BMC Musculoskelet. Disord., 24.","DOI":"10.1186\/s12891-023-06821-z"},{"key":"ref_6","first-page":"e12670","article-title":"The prevalence of fibromyalgia among medical students at King Abdulaziz University: A cross-sectional study","volume":"13","author":"Samman","year":"2021","journal-title":"Cureus"},{"key":"ref_7","first-page":"2577","article-title":"Fibromyalgia in inflammatory bowel disease","volume":"26","author":"Buskila","year":"1999","journal-title":"J. Rheumatol."},{"key":"ref_8","first-page":"590","article-title":"Fibromyalgia and chronic widespread pain in patients with inflammatory bowel disease: A population survey","volume":"28","author":"Palm","year":"2001","journal-title":"J. Rheumatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1093\/rheumatology\/keaa036","article-title":"Clinical and sonographic discrimination between fibromyalgia and spondyloarthropathy in inflammatory bowel disease with musculoskeletal pain","volume":"59","author":"Martinis","year":"2020","journal-title":"Rheumatology"},{"key":"ref_10","first-page":"253","article-title":"Prevalence and patterns of inflammatory arthritis and fibromyalgia in inflammatory bowel disease: A single-center cross-sectional study","volume":"42","author":"Hampannavar","year":"2023","journal-title":"Indian J. Gastroenterol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"AlAujan, S.S., Almalag, H.M., Assiri, G.A., Alodaibi, F.A., and Omair, M.A. (2023). Fibromyalgia Rapid Screening Tool (FiRST): Arabic translation and cross-cultural adaptation and validation. Healthcare, 11.","DOI":"10.3390\/healthcare11070961"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"THU0405","DOI":"10.1136\/annrheumdis-2019-eular.5847","article-title":"Prevalence of fibromyalgia in inflammatory bowel disease patients: A single-centre observational prospective study","volume":"78","author":"Tinazzi","year":"2019","journal-title":"Ann. Rheum. Dis."},{"key":"ref_13","first-page":"352","article-title":"Fibromyalgia Syndrome in 104 Iraqi Patients with Inflammatory Bowel Disease","volume":"10","author":"Jassim","year":"2011","journal-title":"Iraqi Postgrad. Med. J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"POS0023","DOI":"10.1136\/annrheumdis-2022-eular.3862","article-title":"Prevalence and impact of fibromyalgia syndrome in a cohort of patients with inflammatory bowel disease","volume":"81","author":"Guida","year":"2022","journal-title":"Ann. Rheum. Dis."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"P0375","DOI":"10.1093\/ecco-jcc\/jjae190.0549","article-title":"Fibromyalgia as a predictive factor of fatigue and reduced quality of life in patients with inflammatory bowel disease","volume":"19","author":"Prado","year":"2025","journal-title":"J. Crohns Colitis"},{"key":"ref_16","first-page":"377","article-title":"Does fibromyalgia affect the quality of life in patients with inflammatory bowel disease","volume":"4","author":"Can","year":"2021","journal-title":"J. Health Sci. Med."},{"key":"ref_17","first-page":"E289","article-title":"Is fibromyalgia risk higher among male and young inflammatory bowel disease patients?","volume":"21","author":"Chen","year":"2018","journal-title":"Pain Physician"},{"key":"ref_18","first-page":"664","article-title":"A diagnosis of rheumatoid arthritis, endometriosis or inflammatory bowel disease is associated with later onset of fibromyalgia and chronic widespread pain","volume":"23","author":"Bondesson","year":"2019","journal-title":"Eur. J. Pain"},{"key":"ref_19","first-page":"876","article-title":"Association of fibromyalgia with cancerous and noncancerous gastrointestinal comorbidities: A cross-sectional study","volume":"40","author":"Savin","year":"2022","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_20","first-page":"517","article-title":"Symptoms of central sensitization in patients with inflammatory bowel disease: A case\u2013control study","volume":"20","author":"Falling","year":"2020","journal-title":"Scand. J. Pain"},{"key":"ref_21","first-page":"8","article-title":"Central hypersensitivity: A model for persistent musculoskeletal pain in inflammatory bowel diseases","volume":"128","author":"Falling","year":"2019","journal-title":"Med. Hypotheses"},{"key":"ref_22","first-page":"P105","article-title":"Co-occurrence of fibromyalgia and inflammatory bowel disease","volume":"64","author":"Boudokhane","year":"2025","journal-title":"Rheumatology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.1093\/ibd\/izac015.063","article-title":"Non-immune mediated musculoskeletal disease in Crohn\u2019s disease patients evaluated for inflammatory spondyloarthritis: A pilot study","volume":"28","author":"Schwartzman","year":"2022","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"P284","DOI":"10.1093\/ecco-jcc\/jjz203.413","article-title":"Disentangling fibromyalgia from spondyloarthropathy in patients with inflammatory bowel disease","volume":"14","author":"Variola","year":"2020","journal-title":"J. Crohns Colitis"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1093\/ecco-jcc\/jjaa096","article-title":"The IBIS-Q: A novel tool to detect axial and peripheral arthritis in inflammatory bowel disease patients","volume":"14","author":"Variola","year":"2020","journal-title":"J. Crohns Colitis"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/3\/1203\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T16:57:56Z","timestamp":1770137876000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/3\/1203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,3]]},"references-count":25,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,2]]}},"alternative-id":["jcm15031203"],"URL":"https:\/\/doi.org\/10.3390\/jcm15031203","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,3]]}}}