{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T15:24:00Z","timestamp":1784042640858,"version":"3.55.0"},"reference-count":31,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Minimally invasive glaucoma surgery, often performed with phacoemulsification (PHACO-MIGS), for the management of primary open angle glaucoma (POAG), has good clinical outcomes and safety profiles. However, few studies have comprehensively evaluated the impact of PHACO-MIGS on patients\u2019 quality of life (QoL). We determined the post-operative effectiveness of PHACO-MIGS on glaucoma-specific QoL domains in mild\u2013moderate POAG patients. Methods: In this prospective study, adults aged \u2265 21 years with mild\u2013moderate POAG in one eye scheduled for PHACO-MIGS at the Singapore National Eye Centre were administered a digital patient-reported outcome measure (PROM) that utilizes computerized adaptive testing (CAT) to precisely estimate glaucoma-specific QoL across 12 different domains (GlauCATTM), pre-surgery and at 6 months post-surgery. The 12 domains included the following: Visual Symptoms (VSs), Ocular Comfort Symptoms (OSs), Emotional (EM), Activity Limitation (AL), Driving (DV), Lighting (LT), Mobility (MB), Treatment Convenience (TCV), Concerns (CNs), Social (SC), General Convenience (GCV), and Economic (EC). Clinical variables collected included intraocular pressure (IOP), better eye visual acuity (VA), visual field deficit (VFD) and number of glaucoma drops prescribed. Linear mixed models were utilized to determine the within-group changes in each domain, adjusted for relevant clinical, treatment and sociodemographic variables. Results: Of the 83 patients (mean age \u00b1 SD: 70.84 \u00b1 6.70 years; 65.1% male; 90.4% Chinese), 61 (73.5%) underwent PHACO-MIGS with Hydrus\u00ae Microstent, and 22 (26.5%) with iStent\u00ae\u00a0inject. Mean (SD) improvements in VA and IOP were observed post-surgery (0.11 [0.15] LogMAR units and 1.35 [4.20] mmHg, respectively), while VFD and the average number of anti-glaucoma medications prescribed decreased by 0.90 (2.97) dB and 1.30 (0.11) drops (all p &lt; 0.05). Compared to pre-operative scores, four GlauCATTM domains [VSs (13.04%, p &lt; 0.001; ES: 0.84), OSs (6.42%, p &lt; 0.001; ES: 0.52), CNs (7.53%, p = 0.002; ES: 0.51), and GCV (6.34%, p = 0.004; ES: 0.45)] showed significant improvements post-surgery. The improvements across these four domains were driven primarily by a reduction in IOP and improvements in VA. Conclusions: Using a novel and AI-driven QoL PROM, we found significant post-operative improvements in Visual and Ocular Comfort Symptoms, Convenience, and Concerns in patients with POAG undergoing combined PHACO-MIGS, driven by improvements in IOP and VA post-surgery.<\/jats:p>","DOI":"10.3390\/jcm15031215","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T10:02:57Z","timestamp":1770199377000},"page":"1215","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of Combined Cataract and Minimally Invasive Glaucoma Surgeries on Glaucoma-Specific Quality of Life"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0531-0318","authenticated-orcid":false,"given":"Jonathan T. W.","family":"Au Eong","sequence":"first","affiliation":[{"name":"Singapore National Eye Centre, Singapore 168751, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Rong","family":"Low","sequence":"additional","affiliation":[{"name":"Singapore National Eye Centre, Singapore 168751, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0417-2048","authenticated-orcid":false,"given":"Eva K.","family":"Fenwick","sequence":"additional","affiliation":[{"name":"Singapore Eye Research Institute (SERI), Singapore National Eye Centre, Singapore 169856, Singapore"},{"name":"Duke-NUS Medical School, Singapore 169857, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hla M.","family":"Htoon","sequence":"additional","affiliation":[{"name":"Singapore Eye Research Institute (SERI), Singapore National Eye Centre, Singapore 169856, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shamira A.","family":"Perera","sequence":"additional","affiliation":[{"name":"Singapore National Eye Centre, Singapore 168751, Singapore"},{"name":"Singapore Eye Research Institute (SERI), Singapore National Eye Centre, Singapore 169856, Singapore"},{"name":"Duke-NUS Medical School, Singapore 169857, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina T.","family":"Wong","sequence":"additional","affiliation":[{"name":"Singapore National Eye Centre, Singapore 168751, Singapore"},{"name":"Singapore Eye Research Institute (SERI), Singapore National Eye Centre, Singapore 169856, Singapore"},{"name":"Duke-NUS Medical School, Singapore 169857, Singapore"},{"name":"National University of Singapore, Singapore 117551, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8674-5705","authenticated-orcid":false,"given":"Ecosse L.","family":"Lamoureux","sequence":"additional","affiliation":[{"name":"Singapore National Eye Centre, Singapore 168751, Singapore"},{"name":"Singapore Eye Research Institute (SERI), Singapore National Eye Centre, Singapore 169856, Singapore"},{"name":"Duke-NUS Medical School, Singapore 169857, Singapore"},{"name":"National University of Singapore, Singapore 117551, Singapore"},{"name":"University of Melbourne, Melbourne, VIC 3010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5028-605X","authenticated-orcid":false,"given":"Ryan E. K.","family":"Man","sequence":"additional","affiliation":[{"name":"Singapore National Eye Centre, Singapore 168751, Singapore"},{"name":"Singapore Eye Research Institute (SERI), Singapore National Eye Centre, Singapore 169856, Singapore"},{"name":"Duke-NUS Medical School, Singapore 169857, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","article-title":"Global prevalence of glaucoma and projections of glaucoma burden through 2040: A systematic review and meta-analysis","volume":"121","author":"Tham","year":"2014","journal-title":"Ophthalmology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"100801","DOI":"10.1016\/j.preteyeres.2019.100801","article-title":"Beyond intraocular pressure: Optimizing patient-reported outcomes in glaucoma","volume":"76","author":"Fenwick","year":"2020","journal-title":"Prog. 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