{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T22:38:17Z","timestamp":1770331097293,"version":"3.49.0"},"reference-count":26,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Objectives: Transperineal (TP) prostate biopsy is increasingly used because of its lower complication rates compared with the transrectal approach. However, prospective data regarding its effects on erectile and ejaculatory function remain limited. This study prospectively evaluated short-term sexual function outcomes after TP prostate biopsy in sexually active men. Methods: This single-center prospective observational cohort study included men undergoing TP prostate biopsy between 15 April 2025 and 1 September 2025. Indications for biopsy were prostate-specific antigen levels &gt;4 ng\/mL, abnormal digital rectal examination findings, or suspicious lesions (PI-RADS \u2265 3) on multiparametric prostate MRI. Sexual function was assessed at baseline and at 1 and 3 months after biopsy using the International Index of Erectile Function (IIEF-5), the Premature Ejaculation Diagnostic Tool (PEDT), and the Male Sexual Health Questionnaire\u2013Ejaculatory Dysfunction Short Form (MSHQ-EjD-SF). Results: Overall, 249 sexually active men were analyzed. No significant changes in erectile or ejaculatory function were observed in the overall cohort at either follow-up point. In contrast, among 132 men diagnosed with prostate cancer, significant declines were observed in IIEF-5, PEDT, and MSHQ-EjD-SF scores at both 1 and 3 months compared to baseline (all p &lt; 0.001). Conclusions: Transperineal prostate biopsy minimally affects sexual function in the general population. However, prostate cancer patients experience notable deterioration in erectile and ejaculatory outcomes, which may be a transient decline, and long-term follow-up is necessary for this subgroup.<\/jats:p>","DOI":"10.3390\/jcm15031260","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T10:35:37Z","timestamp":1770287737000},"page":"1260","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Does Transperineal Prostate Biopsy Affect Sexual Function? Results from a Prospective Cohort Study"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5558-327X","authenticated-orcid":false,"given":"Kursat","family":"Kucuker","sequence":"first","affiliation":[{"name":"Department of Urology, School of Medicine, Pamukkale University, K\u0131n\u0131kl\u0131, Denizli 20070, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0513-4505","authenticated-orcid":false,"given":"Alper","family":"Simsek","sequence":"additional","affiliation":[{"name":"Department of Urology, School of Medicine, Band\u0131rma Onyedi Eyl\u00fcl University, Balikesir 10250, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Kirdar","sequence":"additional","affiliation":[{"name":"Department of Urology, Band\u0131rma Training and Research Hospital, Balikesir 10200, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1363-8360","authenticated-orcid":false,"given":"Burak","family":"Saglam","sequence":"additional","affiliation":[{"name":"Department of Urology, School of Medicine, Pamukkale University, K\u0131n\u0131kl\u0131, Denizli 20070, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oguz","family":"Celik","sequence":"additional","affiliation":[{"name":"Department of Urology, School of Medicine, Pamukkale University, K\u0131n\u0131kl\u0131, Denizli 20070, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat Can","family":"Erdogan","sequence":"additional","affiliation":[{"name":"Department of Urology, School of Medicine, Pamukkale University, K\u0131n\u0131kl\u0131, Denizli 20070, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6973-4107","authenticated-orcid":false,"given":"Ilker","family":"Gokcedag","sequence":"additional","affiliation":[{"name":"Department of Urology, School of Medicine, Pamukkale University, K\u0131n\u0131kl\u0131, Denizli 20070, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8597-2081","authenticated-orcid":false,"given":"Mesut Berkan","family":"Duran","sequence":"additional","affiliation":[{"name":"Department of Urology, School of Medicine, Pamukkale University, K\u0131n\u0131kl\u0131, Denizli 20070, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aykut","family":"Akinci","sequence":"additional","affiliation":[{"name":"Department of Urology, School of Medicine, Pamukkale University, K\u0131n\u0131kl\u0131, Denizli 20070, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2940-8694","authenticated-orcid":false,"given":"Caner","family":"Ozdemir","sequence":"additional","affiliation":[{"name":"Republic of T\u00fcrkiye-Ministry of Health, Ankara 06800, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuf","family":"Ozlulerden","sequence":"additional","affiliation":[{"name":"Department of Urology, School of Medicine, Pamukkale University, K\u0131n\u0131kl\u0131, Denizli 20070, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sinan","family":"Celen","sequence":"additional","affiliation":[{"name":"Department of Urology, School of Medicine, Pamukkale University, K\u0131n\u0131kl\u0131, Denizli 20070, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.eururo.2019.08.005","article-title":"Recent Global Patterns in Prostate Cancer Incidence and Mortality Rates","volume":"77","author":"Culp","year":"2020","journal-title":"Eur. 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