{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T23:11:15Z","timestamp":1770333075444,"version":"3.49.0"},"reference-count":55,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: The purpose of this study was to evaluate the 2-year postoperative outcomes of iStent inject W implantation combined with phacoemulsification, with a specific focus on comparing results between high myopia (HM) and non-high myopia (non-HM) eyes. Methods: In this retrospective study, subjects were divided into HM and non-HM groups using an axial length cut-off of 26.0 mm. The main outcome measures were intraocular pressure (IOP), number of glaucoma medications, surgical success rates, and postoperative complications. Surgical success was defined as a decrease in glaucoma medical therapy of \u22651 medication without an increase in IOP, or a postoperative IOP \u2264 21 mmHg with a \u226520% reduction. Changes from baseline were analyzed up to 24 months postoperatively. Results: The non-HM group achieved a significant IOP reduction at all postoperative time points. The HM group showed no significant postoperative IOP reduction except at 3 months. The mean number of medications significantly decreased from baseline to 24 months in two groups. The cumulative surgical success rate at 24 months was 48.6% in the non-HM group, whereas it was significantly lower at 19.4% in the HM group (p = 0.038). No significant difference in the incidence of postoperative complications was observed between the groups. Conclusions: The IOP-lowering efficacy of iStent inject W implantation combined with phacoemulsification appeared limited in eyes with HM. These results may suggest the need for careful patient selection and clinical judgment when considering iStent inject W implantation in this population.<\/jats:p>","DOI":"10.3390\/jcm15031265","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T10:35:37Z","timestamp":1770287737000},"page":"1265","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Influence of High Myopia on Outcomes of iStent Inject W Implantation Combined with Cataract Surgery up to 24 Months of Follow-Up"],"prefix":"10.3390","volume":"15","author":[{"given":"Yuto","family":"Shiotani","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Visual Science, Institute of Science Tokyo, Tokyo 113-8519, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0520-0656","authenticated-orcid":false,"given":"Takeshi","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Science, Institute of Science Tokyo, Tokyo 113-8519, Japan"},{"name":"Department of Advanced Ophthalmic Imaging, Institute of Science Tokyo, Tokyo 113-8519, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sota","family":"Yoshimoto","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Science, Institute of Science Tokyo, Tokyo 113-8519, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keigo","family":"Sugisawa","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Science, Institute of Science Tokyo, Tokyo 113-8519, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shintaro","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Science, Institute of Science Tokyo, Tokyo 113-8519, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motohisa","family":"Ohno","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Science, Institute of Science Tokyo, Tokyo 113-8519, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryu","family":"Teramatsu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Science, Institute of Science Tokyo, Tokyo 113-8519, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Iemura","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Science, Institute of Science Tokyo, Tokyo 113-8519, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusaku","family":"Shibata","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Science, Institute of Science Tokyo, Tokyo 113-8519, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoko","family":"Ohno-Matsui","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Science, Institute of Science Tokyo, Tokyo 113-8519, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1001\/jama.2014.3192","article-title":"The Pathophysiology and Treatment of Glaucoma: A Review","volume":"311","author":"Weinreb","year":"2014","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","article-title":"Global Prevalence of Glaucoma and Projections of Glaucoma Burden through 2040: A Systematic Review and Meta-analysis","volume":"121","author":"Tham","year":"2014","journal-title":"Ophthalmology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1001\/archopht.120.10.1268","article-title":"Reduction of Intraocular Pressure and Glaucoma Progression: Results from the Early Manifest Glaucoma Trial","volume":"120","author":"Heijl","year":"2002","journal-title":"Arch. 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