{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:57:42Z","timestamp":1790668662943,"version":"4.1.0"},"reference-count":74,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Bicuspid Aortic Valve (BAV) disease is recognized as the most common congenital heart condition and is frequently associated with complex valvular and aortic disorders. Cardiovascular computed tomography (CT) has become essential for diagnosing BAV, planning procedures, and evaluating patients after treatment. This is largely due to CT\u2019s high spatial resolution and its ability to perform volume imaging effectively. This review provides an up-to-date overview of the increasing role of cardiovascular CT in the management of bicuspid aortic valve (BAV). It covers various aspects, including BAV morphology, optimal sizing for transcatheter aortic valve replacement (TAVR), and post-procedural monitoring. We highlight significant innovations, such as supra-annular sizing techniques and artificial intelligence (AI)-guided analysis, that position CT at the nexus of anatomy, function, and targeted treatment. Additionally, we address controversies concerning inconsistencies in sizing algorithms, recent classification challenges, and radiation exposure. Future development areas include AI predictive tools, radiomic phenotyping, and CT-guided precision medicine. This synthesis aims to provide clinicians and researchers with a high-level guide to the clinical integration of cardiovascular CT and its future in the BAV population. This review provides the most current, comprehensive synthesis on the pivotal role of cardiovascular CT in BAV management, offering a roadmap for integrating advanced imaging into clinical practice and guiding future research priorities.<\/jats:p>","DOI":"10.3390\/jcm15031268","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T15:24:19Z","timestamp":1770305059000},"page":"1268","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cardiovascular CT in Bicuspid Aortic Valve Disease: A State-of-the-Art Narrative Review of Advances, Clinical Integration, and Future Directions"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9083-1374","authenticated-orcid":false,"given":"Muhammad Ali","family":"Jawed","sequence":"first","affiliation":[{"name":"Cardiovascular Research Institute (CVRI), D07 KWR1 Dublin, Ireland"},{"name":"Mater Private Network, D07 KWR1 Dublin, Ireland"},{"name":"Royal College of Surgeons in Ireland (RCSI), D02 YN77 Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0369-5147","authenticated-orcid":false,"given":"Cagri","family":"Ayhan","sequence":"additional","affiliation":[{"name":"Mater Private Network, D07 KWR1 Dublin, Ireland"},{"name":"Royal College of Surgeons in Ireland (RCSI), D02 YN77 Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5224-6393","authenticated-orcid":false,"given":"Robert","family":"Byrne","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute (CVRI), D07 KWR1 Dublin, Ireland"},{"name":"Mater Private Network, D07 KWR1 Dublin, Ireland"},{"name":"Royal College of Surgeons in Ireland (RCSI), D02 YN77 Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7448-9190","authenticated-orcid":false,"given":"Sandeep Singh","family":"Hothi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Royal Wolverhampton Trust, Wolverhampton WV10 0QP, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8767-4929","authenticated-orcid":false,"given":"Sherif","family":"Sultan","sequence":"additional","affiliation":[{"name":"Western Vascular Institute, Department of Vascular and Endovascular Surgery, University Hospital Galway, University of Galway, H91 TK33 Galway, Ireland"},{"name":"Department of Vascular Surgery and Endovascular Surgery, Galway Clinic, Doughiska, Royal College of Surgeons in Ireland and the University of Galway, Affiliated Teaching Hospitals, H91 HHT0 Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7053-6586","authenticated-orcid":false,"given":"Mark","family":"Spence","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute (CVRI), D07 KWR1 Dublin, Ireland"},{"name":"Mater Private Network, D07 KWR1 Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0758-3539","authenticated-orcid":false,"given":"Osama","family":"Soliman","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute (CVRI), D07 KWR1 Dublin, Ireland"},{"name":"Mater Private Network, D07 KWR1 Dublin, Ireland"},{"name":"Royal College of Surgeons in Ireland (RCSI), D02 YN77 Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.21037\/jovs.2019.09.06","article-title":"Concepts and techniques of bicuspid aortic valve repair","volume":"6","author":"Schneider","year":"2020","journal-title":"J. Vis. Surg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.xjtc.2020.12.043","article-title":"Commissural geometry and cusp fusion insights to guide bicuspid aortic valve repair","volume":"7","author":"Jahanyar","year":"2021","journal-title":"JTCVS Tech."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Sundstr\u00f6m, E., and Tretter, J.T. (2023). Impact of Variation in Commissural Angle Between Fused Leaflets in the Functionally Bicuspid Aortic Valve on Hemodynamics and Tissue Biomechanics. Bioengineering, 10.","DOI":"10.3390\/bioengineering10101219"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/j.jtcvs.2007.01.039","article-title":"A classification system for the bicuspid aortic valve from 304 surgical specimens","volume":"133","author":"Sievers","year":"2007","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1136\/hrt.2007.132092","article-title":"The bicuspid aortic valve: An integrated phenotypic classification of leaflet morphology and aortic root shape","volume":"94","author":"Schaefer","year":"2008","journal-title":"Heart"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.cpcardiol.2005.06.002","article-title":"The bicuspid aortic valve","volume":"30","author":"Braverman","year":"2005","journal-title":"Curr. Probl. Cardiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1093\/ejcts\/ezz033","article-title":"Variability of repairable bicuspid aortic valve phenotypes: Towards an anatomical and repair-oriented classification","volume":"56","author":"Mastrobuoni","year":"2019","journal-title":"Eur. J. Cardio-Thorac. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1093\/ejcts\/ezab038","article-title":"International consensus statement on nomenclature and classification of the congenital bicuspid aortic valve and its aortopathy, for clinical, surgical, interventional and research purposes","volume":"60","author":"Michelena","year":"2021","journal-title":"Eur. J. Cardio-Thorac. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.jcct.2019.08.005","article-title":"A simple method to visualize the bicuspid aortic valve pathology by cardiac computed tomography","volume":"14","author":"Amoretti","year":"2020","journal-title":"J. Cardiovasc. Comput. Tomogr."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"5","DOI":"10.5334\/jbsr.2974","article-title":"The Hammock Sign in Computed Tomography as a Detection Aid for Bicuspid Aortic Valves","volume":"107","author":"Devos","year":"2023","journal-title":"J. Belg. Soc. Radiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.3348\/jksr.2022.0170","article-title":"Diagnostic performance of cardiac CT and transthoracic echocardiography for detection of surgically confirmed bicuspid aortic valve: Effect of calcium extent and valve subtypes","volume":"84","author":"Kim","year":"2023","journal-title":"J. Korean Soc. Radiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"20200894","DOI":"10.1259\/bjr.20200894","article-title":"Reporting incidental coronary, aortic valve and cardiac calcification on non-gated thoracic computed tomography, a consensus statement from the BSCI\/BSCCT and BSTI","volume":"94","author":"Williams","year":"2021","journal-title":"Br. J. Radiol."},{"key":"ref_13","first-page":"50","article-title":"Transcatheter aortic valve replacement in low-risk patients with bicuspid aortic valve stenosis","volume":"6","author":"Forrest","year":"2021","journal-title":"JAMA Cardiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/j.jcin.2019.02.051","article-title":"Understanding the interaction between transcatheter aortic valve prostheses and supra-annular structures from post-implant stent geometry","volume":"12","author":"Xiong","year":"2019","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_15","first-page":"100506","article-title":"Imaging, treatment options, patient selection, and outcome considerations for patients with bicuspid aortic valve disease","volume":"1","author":"Ahmad","year":"2022","journal-title":"J. Soc. Cardiovasc. Angiogr. Interv."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1148\/radiol.2393050458","article-title":"Aortic stenosis: Comparative evaluation of 16\u2013detector row CT and echocardiography","volume":"240","author":"Alkadhi","year":"2006","journal-title":"Radiology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jcmg.2018.12.003","article-title":"Computed tomography imaging in the context of transcatheter aortic valve implantation (TAVI)\/transcatheter aortic valve replacement (TAVR) an expert consensus document of the Society of Cardiovascular Computed Tomography","volume":"12","author":"Blanke","year":"2019","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.2214\/AJR.08.1986","article-title":"Differences in aortic valve area measured with CT planimetry and echocardiography (continuity equation) are related to divergent estimates of left ventricular outflow tract area","volume":"192","author":"Halpern","year":"2009","journal-title":"Am. J. Roentgenol."},{"key":"ref_19","first-page":"248","article-title":"Aortic valve area calculation in aortic stenosis by CT and Doppler echocardiography","volume":"8","author":"Clavel","year":"2015","journal-title":"Cardiovasc. Imaging"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1016\/j.jcmg.2019.01.045","article-title":"Why and how to measure aortic valve calcification in patients with aortic stenosis","volume":"12","author":"Pawade","year":"2019","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"ivac274","DOI":"10.1093\/icvts\/ivac274","article-title":"Different calcification patterns of tricuspid and bicuspid aortic valves and their clinical impact","volume":"35","author":"Engler","year":"2022","journal-title":"Interact. Cardiovasc. Thorac. Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e231","DOI":"10.4244\/EIJ-D-19-00236","article-title":"Annular versus supra-annular sizing for TAVI in bicuspid aortic valve stenosis","volume":"15","author":"Kim","year":"2019","journal-title":"EuroIntervention"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Evangelista Masip, A., Galian-Gay, L., Guala, A., Lopez-Sainz, A., Teixido-Tura, G., Ruiz Munoz, A., Valente, F., Gutierrez, L., Fernandez-Galera, R., and Casas, G. (2022). Unraveling Bicuspid Aortic Valve Enigmas by Multimodality Imaging: Clinical Implications. J. Clin. Med., 11.","DOI":"10.3390\/jcm11020456"},{"key":"ref_24","first-page":"4","article-title":"CT scan as a tool to evaluate root reconstruction and aortic valve repair","volume":"9","author":"Irace","year":"2025","journal-title":"Vessel Plus"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1001\/jamacardio.2016.5228","article-title":"Prognostic Implications of Raphe in Bicuspid Aortic Valve Anatomy","volume":"2","author":"Kong","year":"2017","journal-title":"JAMA Cardiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e005987","DOI":"10.1161\/CIRCIMAGING.117.005987","article-title":"Bicuspid Aortic Valve: What to Image in Patients Considered for Transcatheter Aortic Valve Replacement?","volume":"10","author":"Kong","year":"2017","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1001\/jama.2011.1286","article-title":"Incidence of aortic complications in patients with bicuspid aortic valves","volume":"306","author":"Michelena","year":"2011","journal-title":"JAMA"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1016\/j.athoracsur.2015.04.126","article-title":"Aortic dissection in patients with bicuspid aortic valve\u2013associated aneurysms","volume":"100","author":"Wojnarski","year":"2015","journal-title":"Ann. Thorac. Surg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/j.jacc.2020.07.005","article-title":"Bicuspid aortic valve morphology and outcomes after transcatheter aortic valve replacement","volume":"76","author":"Yoon","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1093\/ejcts\/ezz065","article-title":"Morphological modification of the aortic annulus in tricuspid and bicuspid valves after aortic valve reimplantation: An electrocardiography-gated computed tomography study","volume":"56","author":"Chirichilli","year":"2019","journal-title":"Eur. J. Cardio-Thorac. Surg."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1093\/icvts\/ivz325","article-title":"A direct correlation between commissural orientation and annular shape in bicuspid aortic valves: A new anatomical and computed tomography classification","volume":"30","author":"Chirichilli","year":"2020","journal-title":"Interact. Cardiovasc. Thorac. Surg."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"7612","DOI":"10.1038\/s41598-022-11788-3","article-title":"TAVI-CT score to evaluate the anatomic risk in patients undergoing transcatheter aortic valve implantation","volume":"12","author":"Corcione","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1161\/CIRCINTERVENTIONS.120.009586","article-title":"Feasibility and Validity of Computed Tomography-Derived Fractional Flow Reserve in Patients With Severe Aortic Stenosis","volume":"14","author":"Michail","year":"2021","journal-title":"Circ. Cardiovasc. Interv."},{"key":"ref_34","first-page":"101293","article-title":"Feasibility and Utility of Anatomical and Physiological Evaluation of Coronary Disease With Cardiac CT in Severe Aortic Stenosis (FUTURE-AS Registry): Rationale and Design","volume":"3","author":"Khoo","year":"2024","journal-title":"J. Soc. Cardiovasc. Angiogr. Interv."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.jcmg.2021.09.013","article-title":"Combined cCTA and TAVR Planning for Ruling Out Significant CAD","volume":"15","author":"Gohmann","year":"2022","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s10554-025-03333-w","article-title":"Real-world application of CCTA with CT-FFR for coronary assessment pre-TAVI: The CT2TAVI study","volume":"41","author":"Hussain","year":"2025","journal-title":"Int. J. Cardiovasc. Imaging"},{"key":"ref_37","first-page":"1","article-title":"Two birds with one stone: Pre-TAVI coronary CT angiography combined with FFR helps screen for coronary stenosis","volume":"25","author":"Wang","year":"2025","journal-title":"BMC Med. Imaging"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e007107","DOI":"10.1161\/CIRCINTERVENTIONS.118.007107","article-title":"Bicuspid aortic valve anatomy and relationship with devices: The Bavard multicenter Registry: A European picture of contemporary multidetector computed tomography sizing for bicuspid valves","volume":"12","author":"Tchetche","year":"2019","journal-title":"Circ. Cardiovasc. Interv."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"C233","DOI":"10.1093\/eurheartj\/suac014","article-title":"Update on supra-annular sizing of transcatheter aortic valve prostheses in raphe-type bicuspid aortic valve disease according to the LIRA method","volume":"24","author":"Iannopollo","year":"2022","journal-title":"Eur. Heart J. Suppl."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.ijcard.2020.05.076","article-title":"Supra-annular sizing of transcatheter aortic valve prostheses in raphe-type bicuspid aortic valve disease: The LIRA method","volume":"317","author":"Iannopollo","year":"2020","journal-title":"Int. J. Cardiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.jcct.2020.01.007","article-title":"Bicuspid aortic valve sizing for transcatheter aortic valve implantation: Development and validation of an algorithm based on multi-slice computed tomography","volume":"14","author":"Petronio","year":"2020","journal-title":"J. Cardiovasc. Comput. Tomogr."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s40119-021-00223-9","article-title":"Expert Consensus on Sizing and Positioning of SAPIEN 3\/Ultra in Bicuspid Aortic Valves","volume":"10","author":"Blackman","year":"2021","journal-title":"Cardiol. Ther."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ahj.2024.04.011","article-title":"Comparison of downsizing strategy (HANGZHOU Solution) and standard annulus sizing strategy in type 0 bicuspid aortic stenosis patients undergoing transcatheter aortic valve replacement: Rationale and design of a randomized clinical trial","volume":"274","author":"Guo","year":"2024","journal-title":"Am. Heart J."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2968","DOI":"10.1097\/CM9.0000000000002517","article-title":"Anatomical morphology of the aortic valve in Chinese aortic stenosis patients and clinical results after downsize strategy of transcatheter aortic valve replacement","volume":"135","author":"Niu","year":"2022","journal-title":"Chin. Med. J."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"502","DOI":"10.4244\/EIJ-D-23-00021","article-title":"Transcatheter aortic valve implantation with the Evolut platform for bicuspid aortic valve stenosis: The international, multicentre, prospective BIVOLUTX registry","volume":"19","author":"Ziviello","year":"2023","journal-title":"EuroIntervention"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"455","DOI":"10.4244\/EIJ-E-23-00037","article-title":"Bicuspid is different","volume":"19","author":"Bleiziffer","year":"2023","journal-title":"EuroIntervention"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.carrev.2018.11.025","article-title":"TAVR Bicuspid Aortic Valves: Past Is Prologue Or Tempest A Teapot?","volume":"20","author":"Barker","year":"2019","journal-title":"Cardiovasc. Revascularization Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"100527","DOI":"10.1016\/j.shj.2025.100527","article-title":"Size up Bicuspid With the Lira Method: The SUBLIME Multicenter Study","volume":"9","author":"Bellini","year":"2025","journal-title":"Struct. Heart"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Costa, G., Angelillis, M., and Petronio, A.S. (2022). Bicuspid valve sizing for transcatheter aortic valve implantation: The missing link. Front. Cardiovasc. Med., 8.","DOI":"10.3389\/fcvm.2021.770924"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.jcct.2020.01.008","article-title":"Annular versus supra-annular sizing for transcatheter aortic valve replacement in bicuspid aortic valve disease","volume":"14","author":"Blanke","year":"2020","journal-title":"J. Cardiovasc. Comput. Tomogr."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"e002779","DOI":"10.1136\/openhrt-2024-002779","article-title":"Machine-learning versus traditional methods for prediction of all-cause mortality after transcatheter aortic valve implantation: A systematic review and meta-analysis","volume":"12","author":"Zaka","year":"2025","journal-title":"Open Heart"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Benjamin, M.M., and Rabbat, M.G. (2024). Artificial Intelligence in Transcatheter Aortic Valve Replacement: Its Current Role and Ongoing Challenges. Diagnostics, 14.","DOI":"10.3390\/diagnostics14030261"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Shojaei, S., Mousavi, A., Kazemian, S., Armani, S., Maleki, S., Fallahtafti, P., Arashlow, F.T., Daryabari, Y., Naderian, M., and Alkhouli, M. (2025). Artificial Intelligence in Risk Stratification and Outcome Prediction for Transcatheter Aortic Valve Replacement: A Systematic Review and Meta-Analysis. J. Pers. Med., 15.","DOI":"10.3390\/jpm15070302"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.jcct.2024.08.003","article-title":"Artificial Intelligence and Machine Learning for Cardiovascular Computed Tomography (CCT): A White Paper of the Society of Cardiovascular Computed Tomography (SCCT)","volume":"18","author":"Williams","year":"2024","journal-title":"J. Cardiovasc. Comput. Tomogr."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Maniaci, A., Lavalle, S., Gagliano, C., Lentini, M., Masiello, E., Parisi, F., Iannella, G., Cilia, N.D., Salerno, V., and Cusumano, G. (2024). The Integration of Radiomics and Artificial Intelligence in Modern Medicine. Life, 14.","DOI":"10.3390\/life14101248"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Guo, Z., Dong, N.J., Litt, H., Yushkevich, N., Freas, M., Nunez, J., Ferrari, V., Hao, J., Goldfinger, S., and Jolley, M.A. (2025). Towards Patient-Specific Surgical Planning for Bicuspid Aortic Valve Repair: Fully Automated Segmentation of the Aortic Valve in 4D. Proceedings of the 2025 IEEE 22nd International Symposium on Biomedical Imaging (ISBI), Houston, TX, USA, 14\u201317 April 2025, IEEE.","DOI":"10.1109\/ISBI60581.2025.10981269"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1080\/14779072.2025.2533241","article-title":"Artificial intelligence for risk prediction in transcatheter heart valve interventions","volume":"23","author":"Arzamendi","year":"2025","journal-title":"Expert Rev. Cardiovasc. Ther."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Baessler, B., Gotz, M., Antoniades, C., Heidenreich, J.F., Leiner, T., and Beer, M. (2023). Artificial intelligence in coronary computed tomography angiography: Demands and solutions from a clinical perspective. Front. Cardiovasc. Med., 10.","DOI":"10.3389\/fcvm.2023.1120361"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1055\/s-0041-1734363","article-title":"Onsite Computed Tomography Fractional Flow Reserve in Patients with Suspected Stable Coronary Artery Disease Initial Experience","volume":"31","author":"Kapoor","year":"2021","journal-title":"Indian J. Radiol. Imaging"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"37379","DOI":"10.31083\/RCM37379","article-title":"The Emerging Role of Computed Tomography Coronary Angiography in the Left Main Stem Percutaneous Coronary Intervention","volume":"26","author":"Shabbir","year":"2025","journal-title":"Rev. Cardiovasc. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.recesp.2025.02.013","article-title":"Transcatheter aortic valve implantation in bicuspid aortic valves: Present and future","volume":"78","author":"Alperi","year":"2025","journal-title":"Rev. Espa\u00f1ola Cardiol. Engl. Ed."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.jcct.2024.04.014","article-title":"Cardiac computed tomography post-transcatheter aortic valve replacement","volume":"18","author":"He","year":"2024","journal-title":"J. Cardiovasc. Comput. Tomogr."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Tzimas, G., Meier, D., Beneki, E., Antiochos, P., Auberson, D., Leboub, S., Lu, H., Liabot, Q., Zimmerli, A., and Salihu, A. (2025). Current Trends and Future Challenges in Transcatheter Aortic Valve Replacement: Utility of Cardiac Computed Tomography Angiography. J. Clin. Med., 14.","DOI":"10.3390\/jcm14072474"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s00392-024-02545-9","article-title":"Incidence and predictors of continued ascending aortic dilatation after TAVI in patients with bicuspid aortic stenosis","volume":"114","author":"Jia","year":"2024","journal-title":"Clin. Res. Cardiol."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Das, R., and Puri, R. (2018). Transcatheter Treatment of Bicuspid Aortic Valve Disease: Imaging and Interventional Considerations. Front. Cardiovasc. Med., 5.","DOI":"10.3389\/fcvm.2018.00091"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.ejmp.2020.10.030","article-title":"Photon-counting CT review","volume":"79","author":"Flohr","year":"2020","journal-title":"Phys. Medica"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1148\/rg.2019180115","article-title":"Photon-counting detector CT: System design and clinical applications of an emerging technology","volume":"39","author":"Leng","year":"2019","journal-title":"Radiographics"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/tomography10010001","article-title":"Advantages of Photon-Counting Detector CT in Aortic Imaging","volume":"10","author":"Zanon","year":"2023","journal-title":"Tomography"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"5509","DOI":"10.1007\/s00330-023-09550-y","article-title":"Dynamic myocardial CT perfusion imaging\u2014State of the art","volume":"33","author":"Sliwicka","year":"2023","journal-title":"Eur. Radiol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"ezae113","DOI":"10.1093\/ejcts\/ezae113","article-title":"Morphological and dynamic analysis of the normal aortic valve with 4D computed tomography","volume":"65","author":"Fikani","year":"2024","journal-title":"Eur. J. Cardio-Thorac. Surg."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Bruns, S., Wolterink, J.M., Van Den Boogert, T.P., Henriques, J.P., Baan, J., Planken, R.N., and I\u0161gum, I. (2021). Automatic whole-heart segmentation in 4D TAVI treatment planning CT. Medical Imaging 2021: Image Processing, SPIE.","DOI":"10.1117\/12.2581020"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Piatti, F., Sturla, F., Bissell, M.M., Pirola, S., Lombardi, M., Nesteruk, I., Della Corte, A., Redaelli, A.C.L., and Votta, E. (2017). 4D flow analysis of BAV-related fluid-dynamic alterations: Evidences of wall shear stress alterations in absence of clinically-relevant aortic anatomical remodeling. Front. Physiol., 8.","DOI":"10.3389\/fphys.2017.00441"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.xjtc.2024.06.012","article-title":"Four-dimensional computed tomography analysis of bicuspid aortic valves","volume":"27","author":"Fikani","year":"2024","journal-title":"JTCVS Tech."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Zdanowicz, A., Guzinski, M., Pula, M., Witkowska, A., and Reczuch, K. (2023). Dynamic CT Myocardial Perfusion: The Role of Functional Evaluation in the Diagnosis of Coronary Artery Disease. J. Clin. Med., 12.","DOI":"10.3390\/jcm12227062"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/3\/1268\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T15:43:48Z","timestamp":1770306228000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/3\/1268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,5]]},"references-count":74,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,2]]}},"alternative-id":["jcm15031268"],"URL":"https:\/\/doi.org\/10.3390\/jcm15031268","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,5]]}}}