{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T19:58:35Z","timestamp":1780343915235,"version":"3.54.1"},"reference-count":31,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Therapy of osteomyelitis first aims to control infection of the bone and surrounding tissue. Once that is achieved, surgeons are regularly faced with defects of the bone as a result of the infection. Reconstruction of the bone is necessary. In the past years, various bone substitutes were developed. Since 2022, we have used Fiberfill\u00a9 as a new allogenic material. The aim of this study is to analyze the outcome of patients with chronic osteomyelitis who received bone reconstruction with Fiberfill\u00a9. Methods: Patients who suffered from chronic osteomyelitis and received Fiberfill\u00a9 for bone reconstruction between October 2022 and July 2024 were retrospectively analyzed. Endpoints were infection control, bone healing and function in terms of weight bearing. Data was analyzed descriptively. Results: 38 patients with a mean age of 55.6 years \u00b1 16.4 years standard deviation were analyzed and seen for clinical and radiographic control after surgery with a mean follow up of 60 weeks up to three years. Mean defect size was 2.4 cm. Thirty-four patients (89%) did not have any re-infection. Complications associated with Fiberfill\u00a9 were not found in any patients. Healing of the bone (completely and partially) was found in 35 patients (92%). Twenty-nine patients (78%) walked fully weight bearing. Seven patients were active with partial weight bearing at time of last follow-up (19%). Conclusions: Fiberfill\u00a9 can be regarded as a bone substitute for reconstruction of bone defects in therapy of osteomyelitis. We did not find clear disadvantages or a high number of complications after filling up bone defects with Fiberfill\u00a9.<\/jats:p>","DOI":"10.3390\/jcm15031277","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T15:24:19Z","timestamp":1770305059000},"page":"1277","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Fiberfill\u00a9\u2014A New Bone Substitute for Treatment of Chronic Osteomyelitis?"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1760-6976","authenticated-orcid":false,"given":"Hendrik","family":"Sch\u00f6llmann","sequence":"first","affiliation":[{"name":"Department of Orthopedic and Trauma Surgery, BG Klinikum Duisburg, Gro\u00dfenbaumer Allee 250, 47249 Duisburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika","family":"Weichert","sequence":"additional","affiliation":[{"name":"Department of Orthopedic and Trauma Surgery, BG Klinikum Duisburg, Gro\u00dfenbaumer Allee 250, 47249 Duisburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0501-5466","authenticated-orcid":false,"given":"Claas","family":"Neidlein","sequence":"additional","affiliation":[{"name":"Department for Arthroscopic Surgery, Sports Traumatology & Sports Medicine, BG Klinikum Duisburg, Gro\u00dfenbaumer Allee 250, 47249 Duisburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaus","family":"Brinkmann","sequence":"additional","affiliation":[{"name":"Department of Orthopedic and Trauma Surgery, BG Klinikum Duisburg, Gro\u00dfenbaumer Allee 250, 47249 Duisburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6641-5506","authenticated-orcid":false,"given":"Marcel","family":"Dudda","sequence":"additional","affiliation":[{"name":"Department of Orthopedic and Trauma Surgery, BG Klinikum Duisburg, Gro\u00dfenbaumer Allee 250, 47249 Duisburg, Germany"},{"name":"Department of Trauma, Hand and Reconstructive Surgery, University Hospital Essen, University of Duisburg-Essen, Hufelandstra\u00dfe 55, 45147 Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Steinhausen","sequence":"additional","affiliation":[{"name":"Department of Orthopedic and Trauma Surgery, BG Klinikum Duisburg, Gro\u00dfenbaumer Allee 250, 47249 Duisburg, Germany"},{"name":"Department of Trauma, Hand and Reconstructive Surgery, University Hospital Essen, University of Duisburg-Essen, Hufelandstra\u00dfe 55, 45147 Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Jagosz, M., W\u0119grzyn, P., Ch\u0119ci\u0144ski, M., Smor\u0105g, M., Kr\u00f3li\u0144ski, J., Manasterski, S., Ostrowski, P., and Elsaftawy, A. (2025). Reconstructive Strategies in Post-Traumatic Osteomyelitis of the Lower Limb: A Case Series and Surgical Algorithm Analysis. J. Clin. Med., 14.","DOI":"10.3390\/jcm14196746"},{"key":"ref_2","first-page":"395","article-title":"Osteomyelitis: Diagnosis and Treatment","volume":"104","author":"Bury","year":"2021","journal-title":"Am. Fam. Physician"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Van der Cruyssen, F., Forrest, M., Holmes, S., and Bhatti, N. (2025). A Systematic Review and Meta-Analysis of Fracture-Related Infections in Maxillofacial Trauma: Incidence, Risk Factors, and Management Strategies. J. Clin. Med., 14.","DOI":"10.3390\/jcm14041332"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Armbruster, J., Bussmann, F., Freischmidt, H., Reiter, G., Gruetzner, P.A., and El Barbari, J.S. (2024). Treatment of High-Grade Chronic Osteomyelitis and Nonunions with PerOssal\u00ae: A Retrospective Analysis of Clinical Efficacy and Patient Perspectives. J. Clin. Med., 13.","DOI":"10.20944\/preprints202411.2159.v1"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0140-6736(04)16727-5","article-title":"Osteomyelitis","volume":"364","author":"Lew","year":"2004","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1093\/cid\/cir842","article-title":"Systemic Antibiotic Therapy for Chronic Osteomyelitis in Adults","volume":"54","author":"Spellberg","year":"2012","journal-title":"Clin. Infect. Dis. Off. Publ. Infect. Dis. Soc. Am."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Wu, S., Wu, B., Liu, Y., Deng, S., Lei, L., and Zhang, H. (2022). Mini Review Therapeutic Strategies Targeting for Biofilm and Bone Infections. Front. Microbiol., 13.","DOI":"10.3389\/fmicb.2022.936285"},{"key":"ref_8","unstructured":"Helmholtz-Zentrums f\u00fcr Infektionsforschung (2026, January 25). Biofilme\u2014Ein Leben im Schleim. Available online: https:\/\/www.helmholtz-hzi.de\/wissen\/wissensportal\/biofilme\/."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/s41579-022-00686-0","article-title":"Skeletal infections: Microbial pathogenesis, immunity and clinical management","volume":"20","author":"Masters","year":"2022","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1302\/0301-620X.96B6.33014","article-title":"A comparative study of the use of bioactive glass S53P4 and antibiotic-loaded calcium-based bone substitutes in the treatment of chronic osteomyelitis: A retrospective comparative study","volume":"96-B","author":"Logoluso","year":"2014","journal-title":"Bone Jt. J."},{"key":"ref_11","first-page":"6984656","article-title":"Clinical Application of Antimicrobial Bone Graft Substitute in Osteomyelitis Treatment: A Systematic Review of Different Bone Graft Substitutes Available in Clinical Treatment of Osteomyelitis","volume":"2016","author":"Geurts","year":"2016","journal-title":"BioMed Res. Int."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1007\/s00113-020-00861-z","article-title":"Knochentransplantation oder Biomaterial?","volume":"124","author":"Rupp","year":"2021","journal-title":"Unfallchirurg"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"S116","DOI":"10.1016\/j.injury.2014.10.034","article-title":"Incidence of donor site morbidity following harvesting from iliac crest or RIA graft","volume":"45","author":"Calori","year":"2014","journal-title":"Injury"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1186\/s13018-021-02364-y","article-title":"More weighted cancellous bone can be harvested from the proximal tibia with less donor site pain than anterior iliac crest corticocancellous bone harvesting: Retrospective review","volume":"16","author":"Kim","year":"2021","journal-title":"J. Orthop. Surg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"73","DOI":"10.5194\/jbji-6-73-2021","article-title":"Bioactive glass S53P4 vs. autologous bone graft for filling defects in patients with chronic osteomyelitis and infected non-unions\u2014A single center experience","volume":"6","author":"Steinhausen","year":"2021","journal-title":"J. Bone Jt. Infect."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.14245\/ns.2346760.380","article-title":"Biomechanical Study of 3 Osteoconductive Materials Applied in Pedicle Augmentation and Revision for Osteoporotic Vertebrae: Allograft Bone Particles, Calcium Phosphate Cement, Demineralized Bone Matrix","volume":"20","author":"Jia","year":"2023","journal-title":"Neurospine"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1055\/a-1692-0760","article-title":"Knochenaufbau und Knochenersatzmaterialien","volume":"17","author":"Markus","year":"2022","journal-title":"Orthop. Unfallchirurgie Up2date"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Jindal, A., Bhattacharya, J., and Moulick, R.G. (2022). Micro- and Nanostructured Biomaterials for Bone Tissue Engineering. Handbook of Research on Nano-Drug Delivery and Tissue Engineering, Apple Academic Press.","DOI":"10.1201\/9781003161196-15"},{"key":"ref_19","unstructured":"(2025, December 16). DIZG Jahresbericht 2022. Available online: https:\/\/dizg.de\/wp-content\/uploads\/2025\/08\/jahresbericht2022_web.pdf."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.injury.2017.08.040","article-title":"Fracture-related infection: A consensus on definition from an international expert group","volume":"49","author":"Metsemakers","year":"2018","journal-title":"Injury"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1007\/s00113-025-01607-5","article-title":"Behandlung von kn\u00f6chernen Defekten in Femur und Tibia","volume":"128","author":"Reiter","year":"2025","journal-title":"Unfallchirurgie"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1177\/095952871300400115","article-title":"Pathological Researches respecting the Diseases of Joints","volume":"4","author":"Brodie","year":"1813","journal-title":"Med.-Chir. Trans."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.cjtee.2023.01.003","article-title":"Surgical management of chronic osteomyelitis: Organisms, recurrence and treatment outcome","volume":"26","author":"Subramanyam","year":"2023","journal-title":"Chin. J. Traumatol. Zhonghua Chuang Shang Za Zhi"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1097\/00003086-198411000-00014","article-title":"Antibiotic-loaded acrylic cement: Current concepts","volume":"190","author":"Buchholz","year":"1984","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"17685","DOI":"10.1038\/s41598-021-97246-y","article-title":"Staphylococcus aureus internalization impairs osteoblastic activity and early differentiation process","volume":"11","author":"Mouton","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Bloem, A., Bax, H.I., Yusuf, E., and Verkaik, N.J. (2021). New-Generation Antibiotics for Treatment of Gram-Positive Infections: A Review with Focus on Endocarditis and Osteomyelitis. J. Clin. Med., 10.","DOI":"10.3390\/jcm10081743"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1002\/jbm.b.34911","article-title":"The clinical use of bone graft substitutes in orthopedic surgery in Germany\u2014A 10-years survey from 2008 to 2018 of 1,090,167 surgical interventions","volume":"110","author":"Rupp","year":"2021","journal-title":"J. Biomed. Mater. Res. Part B Appl. Biomater."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1055\/s-0043-124377","article-title":"The Use of Bioactive Glass S53P4 as Bone Graft Substitute in the Treatment of Chronic Osteomyelitis and Infected Non-Unions\u2014A Retrospective Study of 50 Patients","volume":"156","author":"Malat","year":"2018","journal-title":"Z. Orthop. Unfallchirurgie"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Hackenberg, R.K., Schmitt-S\u00e1nchez, F., Endler, C., Tischler, V., Surendar, J., Kabir, K., Welle, K., Burger, C., Wirtz, D.C., and Schildberg, F.A. (2025). Bacterial Osteomyelitis in the Lower Extremities: Analysis of Histology and MRI Findings in a Case-Control Pilot Study. J. Clin. Med., 14.","DOI":"10.3390\/jcm14144877"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Bormann, N., Schmock, A., Hanke, A., Eras, V., Ahmed, N., Kissner, M.S., Wildemann, B., and Brune, J.C. (2023). Analysis of the Ability of Different Allografts to Act as Carrier Grafts for Local Drug Delivery. J. Funct. Biomater., 14.","DOI":"10.3390\/jfb14060305"},{"key":"ref_31","first-page":"684826","article-title":"Clinical Applications of S53P4 Bioactive Glass in Bone Healing and Osteomyelitic Treatment: A Literature Review","volume":"2015","author":"Geurts","year":"2015","journal-title":"BioMed Res. Int."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/3\/1277\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T15:44:53Z","timestamp":1770306293000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/3\/1277"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,5]]},"references-count":31,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,2]]}},"alternative-id":["jcm15031277"],"URL":"https:\/\/doi.org\/10.3390\/jcm15031277","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,5]]}}}