{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T10:36:14Z","timestamp":1784025374268,"version":"3.55.0"},"reference-count":33,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Introduction: Lung cancer is a leading cause of cancer-related deaths globally, with approximately 1.5 million new peripheral pulmonary lesions (PPLs) detected annually in the United States. Robotic-assisted bronchoscopy (RAB) has emerged as a promising technology, with two platforms initially approved, the Monarch platform (Auris Health Inc, Redwood City, CA, USA) and the Ion Endoluminal System (Intuitive Surgical, Sunnyvale, CA, USA), offering improved stability and distal airway visualization. As RAB adoption increases, there is a critical need for comparative effectiveness data of these systems to guide clinical decision-making and institutional investments. This study aims to compare the diagnostic yield and safety profiles of the Ion and Monarch RAB platforms after introduction at a single institution. Methods: We conducted a retrospective chart review of patients undergoing RAB in the first six months following the introduction of each platform. Demographic and radiographic data were collected. Diagnostic yield was defined as obtaining a malignant or specific benign diagnosis from bronchoscopy. Results: The study included 56 Ion and 36 Monarch procedures. Diagnostic yield was similar between Ion (75%) and Monarch (72%) groups (p = 0.8), with an adjusted odds ratio 0.89 (95% CI 0.30\u20132.72). Complications were low, with one pneumothorax occurring in each group. Conclusions: Early adoption and use of both RAB platforms suggests comparable diagnostic yields and safety profiles in our limited sample size. Larger studies including standardized anesthesia protocol and systematic use of real-time imaging are needed for further evaluation and comparative analysis.<\/jats:p>","DOI":"10.3390\/jcm15031284","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T16:30:47Z","timestamp":1770309047000},"page":"1284","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Shape-Sensing Robotic-Assisted Bronchoscopy vs. Electromagnetic Robotic-Assisted Bronchoscopy\u2014A Comparative Cohort Study"],"prefix":"10.3390","volume":"15","author":[{"given":"See-Wei","family":"Low","sequence":"first","affiliation":[{"name":"Department of Pulmonary Medicine, Cleveland Clinic, Cleveland, OH 44195, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima","family":"Abdeljaleel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Cleveland Clinic, Fairview Hospital, Cleveland, OH 44111, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett","family":"Kemper","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Cleveland Clinic Main Campus, Cleveland, OH 44195, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4663-6202","authenticated-orcid":false,"given":"Yifan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH 44195, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH 44195, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Yurosko","sequence":"additional","affiliation":[{"name":"Departments of Pulmonary Medicine and Critical Care Medicine, Cleveland Clinic, Cleveland, OH 44195, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9871-8904","authenticated-orcid":false,"given":"Graham","family":"Stockdale","sequence":"additional","affiliation":[{"name":"Departments of Pulmonary Medicine and Critical Care Medicine, Cleveland Clinic, Cleveland, OH 44195, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Gillespie","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Cleveland Clinic, Cleveland, OH 44195, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Gildea","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Cleveland Clinic, Cleveland, OH 44195, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonali","family":"Sethi","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Cleveland Clinic, Cleveland, OH 44195, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Cicenia","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Cleveland Clinic, Cleveland, OH 44195, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Machuzak","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Cleveland Clinic, Cleveland, OH 44195, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8133-4173","authenticated-orcid":false,"given":"Francisco","family":"Almeida","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Cleveland Clinic, Cleveland, OH 44195, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1136-8287","authenticated-orcid":false,"given":"Bryan S.","family":"Benn","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Cleveland Clinic, Cleveland, OH 44195, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,5]]},"reference":[{"key":"ref_1","first-page":"17","article-title":"Cancer statistics, 2023","volume":"73","author":"Siegel","year":"2023","journal-title":"CA Cancer J. Clin."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"National Lung Screening Trial Research Team, Aberle, D.R., Adams, A.M., Berg, C.D., Black, W.C., Clapp, J.D., Fagerstrom, R.M., Gareen, I.F., Gatsonis, C., and Marcus, P.M. (2011). Reduced lung-cancer mortality with low-dose computed tomographic screening. N. Engl. J. Med., 365, 395\u2013409.","DOI":"10.1056\/NEJMoa1102873"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1164\/rccm.201505-0990OC","article-title":"Recent Trends in the Identification of Incidental Pulmonary Nodules","volume":"192","author":"Gould","year":"2015","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e93S","DOI":"10.1378\/chest.12-2351","article-title":"Evaluation of individuals with pulmonary nodules: When is it lung cancer? Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines","volume":"143","author":"Gould","year":"2013","journal-title":"Chest"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1513\/AnnalsATS.201711-856OC","article-title":"Computed Tomography Bronchus Sign and the Diagnostic Yield of Guided Bronchoscopy for Peripheral Pulmonary Lesions. A Systematic Review and Meta-Analysis","volume":"15","author":"Ali","year":"2018","journal-title":"Ann. Am. Thorac. Soc."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1164\/rccm.200612-1866OC","article-title":"Multimodality bronchoscopic diagnosis of peripheral lung lesions: A randomized controlled trial","volume":"176","author":"Eberhardt","year":"2007","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.jtho.2018.11.013","article-title":"Electromagnetic Navigation Bronchoscopy for Peripheral Pulmonary Lesions: One-Year Results of the Prospective, Multicenter NAVIGATE Study","volume":"14","author":"Folch","year":"2019","journal-title":"J. Thorac. Oncol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1159\/000355710","article-title":"Diagnostic yield and safety of electromagnetic navigation bronchoscopy for lung nodules: A systematic review and meta-analysis","volume":"87","author":"Gex","year":"2014","journal-title":"Respiration"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1164\/rccm.201502-0205OC","article-title":"Ultrathin Bronchoscopy with Multimodal Devices for Peripheral Pulmonary Lesions. A Randomized Trial","volume":"192","author":"Oki","year":"2015","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.chest.2018.08.1026","article-title":"Standard Bronchoscopy With Fluoroscopy vs Thin Bronchoscopy and Radial Endobronchial Ultrasound for Biopsy of Pulmonary Lesions: A Multicenter, Prospective, Randomized Trial","volume":"154","author":"Tanner","year":"2018","journal-title":"Chest"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1378\/chest.11-1764","article-title":"Meta-analysis of guided bronchoscopy for the evaluation of the pulmonary nodule","volume":"142","author":"Nietert","year":"2012","journal-title":"Chest"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Chaddha, U., Kovacs, S.P., Manley, C., Hogarth, D.K., Cumbo-Nacheli, G., Bhavani, S.V., Kumar, R., Shende, M., Egan, J.P., and Murgu, S. (2019). Robot-assisted bronchoscopy for pulmonary lesion diagnosis: Results from the initial multicenter experience. BMC Pulm. Med., 19.","DOI":"10.1186\/s12890-019-1010-8"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1097\/LBR.0000000000000499","article-title":"Robotic Bronchoscopy for Diagnosis of Suspected Lung Cancer: A Feasibility Study","volume":"25","author":"Machuzak","year":"2018","journal-title":"J. Bronchol. Interv. Pulmonol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s00408-021-00421-1","article-title":"Robotic-Assisted Navigation Bronchoscopy as a Paradigm Shift in Peripheral Lung Access","volume":"199","author":"Benn","year":"2021","journal-title":"Lung"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1159\/000498951","article-title":"First Human Use of a New Robotic-Assisted Fiber Optic Sensing Navigation System for Small Peripheral Pulmonary Nodules","volume":"98","author":"Fielding","year":"2019","journal-title":"Respiration"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.chest.2021.07.2169","article-title":"Shape-Sensing Robotic-Assisted Bronchoscopy in the Diagnosis of Pulmonary Parenchymal Lesions","volume":"161","author":"Connolly","year":"2022","journal-title":"Chest"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e01019","DOI":"10.1097\/LBR.0000000000001019","article-title":"Comparing Monarch Versus Ion Robotic-Assisted Bronchoscopy Platforms: A Propensity Score-Matched Analysis","volume":"32","author":"McNierney","year":"2025","journal-title":"J. Bronchol. Interv. Pulmonol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1016\/j.chest.2023.12.024","article-title":"Diagnostic Yield vs Diagnostic Accuracy for Peripheral Lung Biopsy Evaluation: Evidence Supporting a Future Pragmatic End Point","volume":"165","author":"Leonard","year":"2024","journal-title":"Chest"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1164\/rccm.202401-0192ST","article-title":"Assessment of Advanced Diagnostic Bronchoscopy Outcomes for Peripheral Lung Lesions: A Delphi Consensus Definition of Diagnostic Yield and Recommendations for Patient-centered Study Designs. An Official American Thoracic Society\/American College of Chest Physicians Research Statement","volume":"209","author":"Gonzalez","year":"2024","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1378\/chest.14-1425","article-title":"The effect of respiratory motion on pulmonary nodule location during electromagnetic navigation bronchoscopy","volume":"147","author":"Chen","year":"2015","journal-title":"Chest"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.21037\/jtd.2020.01.35","article-title":"Virtual or reality: Divergence between preprocedural computed tomography scans and lung anatomy during guided bronchoscopy","volume":"12","author":"Pritchett","year":"2020","journal-title":"J. Thorac. Dis."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1513\/AnnalsATS.201311-384OC","article-title":"Radial probe endobronchial ultrasound for peripheral pulmonary lesions. A 5-year institutional experience","volume":"11","author":"Chen","year":"2014","journal-title":"Ann. Am. Thorac. Soc."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Pritchett, M.A., Lau, K., Skibo, S., Phillips, K.A., and Bhadra, K. (2021). Anesthesia considerations to reduce motion and atelectasis during advanced guided bronchoscopy. BMC Pulm. Med., 21.","DOI":"10.1186\/s12890-021-01584-6"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1016\/j.chest.2022.06.045","article-title":"Ventilatory Strategy to Prevent Atelectasis During Bronchoscopy Under General Anesthesia: A Multicenter Randomized Controlled Trial (Ventilatory Strategy to Prevent Atelectasis -VESPA- Trial)","volume":"162","author":"Salahuddin","year":"2022","journal-title":"Chest"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1097\/LBR.0000000000000806","article-title":"on behalf of the Interventional Pulmonary Outcomes Group (IPOG). A Direct Comparative Study of Bronchoscopic Navigation Planning Platforms for Peripheral Lung Navigation: The ATLAS Study","volume":"29","author":"Akulian","year":"2022","journal-title":"J. Bronchol. Interv. Pulmonol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1097\/LBR.0000000000000645","article-title":"The Diagnostic Accuracy and Sensitivity for Malignancy of Radial-Endobronchial Ultrasound and Electromagnetic Navigation Bronchoscopy for Sampling of Peripheral Pulmonary Lesions: Systematic Review and Meta-analysis","volume":"27","author":"McGuire","year":"2020","journal-title":"J. Bronchol. Interv. Pulmonol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1513\/AnnalsATS.202301-075OC","article-title":"Diagnostic Performance and Safety Profile of Robotic-assisted Bronchoscopy: A Systematic Review and Meta-Analysis","volume":"20","author":"Ali","year":"2023","journal-title":"Ann. Am. Thorac. Soc."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/1759-7714.15229","article-title":"Robotic-assisted bronchoscopy for the diagnosis of peripheral pulmonary lesions: A systematic review and meta-analysis","volume":"15","author":"Zhang","year":"2024","journal-title":"Thorac. Cancer"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.chest.2022.10.019","article-title":"Shape-Sensing Robotic-Assisted Bronchoscopy vs Digital Tomosynthesis-Corrected Electromagnetic Navigation Bronchoscopy: A Comparative Cohort Study of Diagnostic Performance","volume":"163","author":"Low","year":"2023","journal-title":"Chest"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"107196","DOI":"10.1016\/j.lungcan.2023.107196","article-title":"Diagnostic yield and safety of navigation bronchoscopy: A systematic review and meta-analysis","volume":"180","author":"Kops","year":"2023","journal-title":"Lung Cancer"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.mayocpiqo.2022.02.004","article-title":"Combining Shape-Sensing Robotic Bronchoscopy With Mobile Three-Dimensional Imaging to Verify Tool-in-Lesion and Overcome Divergence: A Pilot Study","volume":"6","author":"Reisenauer","year":"2022","journal-title":"Mayo Clin. Proc. Innov. Qual. Outcomes"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1056\/NEJMoa2414059","article-title":"Navigational Bronchoscopy or Transthoracic Needle Biopsy for Lung Nodules","volume":"392","author":"Lentz","year":"2025","journal-title":"N. Engl. J. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/resp.14368","article-title":"Robotic-assisted bronchoscopy versus CT-guided transthoracic biopsy for diagnosis of pulmonary nodules","volume":"28","author":"Reisenauer","year":"2023","journal-title":"Respirology"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/3\/1284\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T16:37:26Z","timestamp":1770309446000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/3\/1284"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,5]]},"references-count":33,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,2]]}},"alternative-id":["jcm15031284"],"URL":"https:\/\/doi.org\/10.3390\/jcm15031284","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,5]]}}}