{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T07:12:51Z","timestamp":1783581171950,"version":"3.55.0"},"reference-count":29,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:00:00Z","timestamp":1770508800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Degenerative cervical myelopathy (DCM) may result from posture-dependent spinal cord compromise not detectable on neutral imaging. Dynamic MRI can uncover clinically relevant mechanisms underlying otherwise unexplained myelopathy and guide management. This report illustrates a dynamic cervical myelopathy phenotype revealed by flexion\u2013extension imaging and its impact on surgical decision-making. Methods: A 49-year-old man presented with progressive bilateral upper-limb paresthesias, intrinsic hand atrophy, and distal weakness. Neutral cervical MRI, standard radiographs, and flexion\u2013extension MRI were performed to investigate a suspected dynamic etiology, including differentiation from Hirayama disease. Surgical treatment consisted of anterior cervical discectomy and fusion (ACDF), with clinical and radiological follow-up. Results: Neutral MRI showed intramedullary T2 hyperintensity from C4 to C6 without static canal stenosis or frank compression, while radiographs demonstrated segmental kyphosis without instability. Flexion MRI revealed reproducible spinal cord contact with a small cranially located osteophyte at C5\u2013C6, concordant with the myelopathic signal. ACDF at C4\u2013C6 led to clinical improvement. One year later, recurrent symptoms from adjacent-segment pathology (C3\u2013C4 myelopathic signal and C6\u2013C7 foraminal disc herniation) required a second ACDF, resulting in durable neurological stability. Conclusions: This case demonstrates flexion-dependent cord\u2013osteophyte conflict causing cervical myelomalacia in the absence of static stenosis. Dynamic MRI resolved a clinical\u2013radiological mismatch and directly informed surgical planning. Recognition of dynamic myelopathy phenotypes and vigilance for adjacent-segment disease after fusion are essential for optimizing outcomes.<\/jats:p>","DOI":"10.3390\/jcm15041333","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T08:15:54Z","timestamp":1770624954000},"page":"1333","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dynamic Cervical Myelopathy Misleading on Neutral Imaging: The Role of Flexion\u2013Extension MRI"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5968-1986","authenticated-orcid":false,"given":"Leonardo","family":"Anselmi","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, 20090 Milan, Italy"},{"name":"Department of Neurosurgery, IRCSS Humanitas Research Hospital, Via Manzoni 56, Rozzano, 20089 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donato","family":"Creatura","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, 20090 Milan, Italy"},{"name":"Department of Neurosurgery, IRCSS Humanitas Research Hospital, Via Manzoni 56, Rozzano, 20089 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5669-2286","authenticated-orcid":false,"given":"Mario De","family":"Robertis","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, 20090 Milan, Italy"},{"name":"Department of Neurosurgery, IRCSS Humanitas Research Hospital, Via Manzoni 56, Rozzano, 20089 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6081-5963","authenticated-orcid":false,"given":"Ali","family":"Baram","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, IRCSS Humanitas Research Hospital, Via Manzoni 56, Rozzano, 20089 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8805-6484","authenticated-orcid":false,"given":"Emanuele","family":"Stucchi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, 20090 Milan, Italy"},{"name":"Department of Neurosurgery, IRCSS Humanitas Research Hospital, Via Manzoni 56, Rozzano, 20089 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2810-7622","authenticated-orcid":false,"given":"Gabriele","family":"Capo","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, IRCSS Humanitas Research Hospital, Via Manzoni 56, Rozzano, 20089 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6048-891X","authenticated-orcid":false,"given":"Jad","family":"El Choueiri","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, 20090 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Pessina","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, 20090 Milan, Italy"},{"name":"Department of Neurosurgery, IRCSS Humanitas Research 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