{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:12:57Z","timestamp":1787163177627,"version":"build-2736575974"},"reference-count":32,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:00:00Z","timestamp":1770508800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: One of the main tools for investigating pulmonary disorders is computed tomography. Starting with a CT, analyses can be qualitative (e.g., direct interpretation of 2D slices, virtual bronchoscopy) or quantitative (e.g., fibrosis score). Qualitative analyses can be performed without segmentation, but quantitative analyses require lung segmentation. Methods: We present the concepts for a class of lung segmentation methods that use region-growing algorithms, the implementation and testing details, and the results obtained in our software platform. Accurate segmentation of lung regions from medical images is a crucial step in computer-aided diagnosis (CAD) systems for pulmonary diseases such as chronic obstructive pulmonary disease (COPD), pneumonia, and lung cancer. Manual segmentation is time-consuming and subjective, while fully automated methods may fail under challenging imaging conditions. Results: This article presents a semi-automated lung segmentation approach, based on region-growing methods, that balances automation with user control. Conclusions: The proposed technique effectively delineates lung boundaries in computed tomography (CT), minimizing computational complexity and manual effort.<\/jats:p>","DOI":"10.3390\/jcm15041339","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T08:15:54Z","timestamp":1770624954000},"page":"1339","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Semi-Automated Lung Segmentation Based on Region-Growing Methods in Interstitial Lung Disease"],"prefix":"10.3390","volume":"15","author":[{"given":"M\u0103d\u0103lin-Cristian","family":"Moraru","sequence":"first","affiliation":[{"name":"Doctoral School, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"},{"name":"SC SPAD IMAGING INTERNATIONAL Center Craiova, 200352 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiana-Iulia","family":"Dumitrescu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzana","family":"M\u0103ce\u0219","sequence":"additional","affiliation":[{"name":"SC SPAD IMAGING INTERNATIONAL Center Craiova, 200352 Craiova, Romania"},{"name":"Department of Radiology and Medical Imaging, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"},{"name":"Department of Radiology and Medical Imaging, University Emergency County Clinical Hospital, 200642 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u0103t\u0103lin","family":"Ciob\u00eerc\u0103","sequence":"additional","affiliation":[{"name":"SC SPAD IMAGING INTERNATIONAL Center Craiova, 200352 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihai","family":"Popescu","sequence":"additional","affiliation":[{"name":"SC SPAD IMAGING INTERNATIONAL Center Craiova, 200352 Craiova, Romania"},{"name":"Department of Radiology and Medical Imaging, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"},{"name":"Department of Radiology and Medical Imaging, University Emergency County Clinical Hospital, 200642 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luana Corina","family":"Lascu","sequence":"additional","affiliation":[{"name":"SC SPAD IMAGING INTERNATIONAL Center Craiova, 200352 Craiova, Romania"},{"name":"Department of Radiology and Medical Imaging, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"},{"name":"Department of Radiology and Medical Imaging, University Emergency County Clinical Hospital, 200642 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7578-8048","authenticated-orcid":false,"given":"Drago\u0219-Ovidiu","family":"Alexandru","sequence":"additional","affiliation":[{"name":"Department of Radiology and Medical Imaging, University Emergency County Clinical Hospital, 200642 Craiova, Romania"},{"name":"Department of Medical Informatics and Biostatistics, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana-Maria","family":"Trasc\u0103","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana Maria","family":"Ciob\u00eerc\u0103","sequence":"additional","affiliation":[{"name":"Slatina Emergency County Hospital, 230008 Slatina, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian-R\u0103zvan","family":"B\u0103lan","sequence":"additional","affiliation":[{"name":"Doctoral School, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"},{"name":"SC SPAD IMAGING INTERNATIONAL Center Craiova, 200352 Craiova, Romania"},{"name":"Department of Radiotherapy, University Emergency County Clinical Hospital Craiova, 200642 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oana Sorina","family":"Tica","sequence":"additional","affiliation":[{"name":"Department of Mother and Child, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radu Teodoru","family":"Popa","sequence":"additional","affiliation":[{"name":"Department of Computer Science, University of Craiova, 200585 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Dumitrescu","sequence":"additional","affiliation":[{"name":"SC SPAD IMAGING INTERNATIONAL Center Craiova, 200352 Craiova, Romania"},{"name":"Department of Radiology and Medical Imaging, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"},{"name":"Department of Radiology and Medical Imaging, University Emergency County Clinical Hospital, 200642 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1056\/NEJMra1705751","article-title":"Idiopathic pulmonary fibrosis","volume":"378","author":"LeLederer","year":"2018","journal-title":"New Engl. 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